{"id":5795,"date":"2021-03-04T20:53:54","date_gmt":"2021-03-05T04:53:54","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=5795"},"modified":"2021-03-04T20:53:54","modified_gmt":"2021-03-05T04:53:54","slug":"delayed-large-local-reactions-to-mrna-1273-vaccine-against-sars-cov-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/04\/delayed-large-local-reactions-to-mrna-1273-vaccine-against-sars-cov-2\/","title":{"rendered":"Delayed Large Local Reactions to MRNA-1273 Vaccine against SARS-CoV-2"},"content":{"rendered":"<ul>\n<li>A case series of 12 patients reported delayed large local reactions (skin redness, tenderness and swelling) in response to the Moderna vaccine within 4 to 11 days (median 8 days) after the first dose. In all cases, the reactions appeared near the injection site after complete resolution of the initial local and systemic symptoms associated with vaccination. 5 of the 12 reactions were 10 cm or larger in diameter. Most patients received treatment, and symptoms resolved within 2 to 11 days of onset (median 6 days). After receiving the second vaccine dose, 3 patients had recurrent reactions similar to the reaction after the first dose and 3 patients had lower grade reactions.<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i>Blumenthal et al.\u00a0(Mar 3, 2021). Delayed Large Local Reactions to MRNA-1273 Vaccine against SARS-CoV-2. New England Journal of Medicine. <\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMc2102131\">https:\/\/doi.org\/10.1056\/NEJMc2102131<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A case series of 12 patients reported delayed large local reactions (skin redness, tenderness and swelling) in response to the Moderna vaccine within 4 to 11 days (median 8 days) after the first dose. In all cases, the reactions appeared near the injection site after complete resolution of the initial local and systemic symptoms associated&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/04\/delayed-large-local-reactions-to-mrna-1273-vaccine-against-sars-cov-2\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[33],"topic":[31],"class_list":["post-5795","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5795","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=5795"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5795\/revisions"}],"predecessor-version":[{"id":5796,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5795\/revisions\/5796"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=5795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=5795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=5795"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=5795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}