{"id":581,"date":"2020-08-28T09:19:35","date_gmt":"2020-08-28T16:19:35","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=581"},"modified":"2020-09-03T09:20:47","modified_gmt":"2020-09-03T16:20:47","slug":"impact-of-famotidine-use-on-clinical-outcomes-of-hospitalized-patients-with-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/28\/impact-of-famotidine-use-on-clinical-outcomes-of-hospitalized-patients-with-covid-19\/","title":{"rendered":"Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19"},"content":{"rendered":"<ul>\n<li>A retrospective propensity-matched observational study (n=878) found that famotidine, a histamine-2 blocker used to treat acid reflux and ulcers, was associated with a decreased risk of in-hospital mortality (OR=0.4, 95% CI: 0.2-0.96) as well as combined outcome of death or intubation (OR=0.5, 95% CI: 0.2-0.96). While patients treated with famotidine were younger (63.5 +\/- 15 vs 67.5 +\/- 15.8), propensity score matching to adjust for age did not change the associations. Forty-eight of 83 (58%) patients in the famotidine group received corticosteroids versus 329\/689 (48%) of patients in the non-famotidine group.<\/li>\n<\/ul>\n<p><em>Mather et al. (Aug 26, 2020). Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19. American Journal of Gastroenterology. <a href=\"https:\/\/journals.lww.com\/ajg\/Documents\/AJG-20-2074_R1.pdf\">https:\/\/journals.lww.com\/ajg\/Documents\/AJG-20-2074_R1.pdf<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A retrospective propensity-matched observational study (n=878) found that famotidine, a histamine-2 blocker used to treat acid reflux and ulcers, was associated with a decreased risk of in-hospital mortality (OR=0.4, 95% CI: 0.2-0.96) as well as combined outcome of death or intubation (OR=0.5, 95% CI: 0.2-0.96). While patients treated with famotidine were younger (63.5 +\/- 15&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/28\/impact-of-famotidine-use-on-clinical-outcomes-of-hospitalized-patients-with-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-581","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/581","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=581"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/581\/revisions"}],"predecessor-version":[{"id":582,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/581\/revisions\/582"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=581"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=581"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=581"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=581"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}