{"id":5978,"date":"2021-03-05T22:49:51","date_gmt":"2021-03-06T06:49:51","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=5978"},"modified":"2021-03-05T22:49:51","modified_gmt":"2021-03-06T06:49:51","slug":"sarilumab-in-patients-admitted-to-hospital-with-severe-or-critical-covid-19-a-randomised-double-blind-placebo-controlled-phase-3-trial","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/05\/sarilumab-in-patients-admitted-to-hospital-with-severe-or-critical-covid-19-a-randomised-double-blind-placebo-controlled-phase-3-trial\/","title":{"rendered":"Sarilumab in Patients Admitted to Hospital with Severe or Critical COVID-19: A Randomised, Double-Blind, Placebo-Controlled, Phase 3 Trial"},"content":{"rendered":"<ul>\n<li>In a randomized, placebo-controlled, double-blind trial, the IL-6 receptor inhibitor sarilumab did not reduce the median time to improvement by day 29 among patients hospitalized for COVID-19 compared to placebo (n=416). Patients receiving placebo had a median time to improvement of 12 days, compared to 10 days among those receiving either 200 mg or 400 mg of sarilumab (HR=1.03 and HR=1.14, respectively). No significant differences were observed in proportions of patients alive by day 29 across the three groups.<\/li>\n<\/ul>\n<p><i>Lescure et al.\u00a0(Mar 4, 2021). Sarilumab in Patients Admitted to Hospital with Severe or Critical COVID-19: A Randomised, Double-Blind, Placebo-Controlled, Phase 3 Trial. The Lancet Respiratory Medicine. <\/i><a href=\"https:\/\/www.thelancet.com\/journals\/lanres\/article\/PIIS2213-2600(21)00099-0\/fulltext\">https:\/\/www.thelancet.com\/journals\/lanres\/article\/PIIS2213-2600(21)00099-0\/fulltext<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a randomized, placebo-controlled, double-blind trial, the IL-6 receptor inhibitor sarilumab did not reduce the median time to improvement by day 29 among patients hospitalized for COVID-19 compared to placebo (n=416). Patients receiving placebo had a median time to improvement of 12 days, compared to 10 days among those receiving either 200 mg or 400&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/05\/sarilumab-in-patients-admitted-to-hospital-with-severe-or-critical-covid-19-a-randomised-double-blind-placebo-controlled-phase-3-trial\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-5978","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=5978"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5978\/revisions"}],"predecessor-version":[{"id":5979,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5978\/revisions\/5979"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=5978"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=5978"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=5978"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=5978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}