{"id":5982,"date":"2021-03-05T22:51:49","date_gmt":"2021-03-06T06:51:49","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=5982"},"modified":"2021-03-05T22:51:49","modified_gmt":"2021-03-06T06:51:49","slug":"time-series-analysis-and-mechanistic-modelling-of-heterogeneity-and-sero-reversion-in-antibody-responses-to-mild-sars-cov-2-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/05\/time-series-analysis-and-mechanistic-modelling-of-heterogeneity-and-sero-reversion-in-antibody-responses-to-mild-sars-cov-2-infection\/","title":{"rendered":"Time Series Analysis and Mechanistic Modelling of Heterogeneity and Sero-Reversion in Antibody Responses to Mild SARS-CoV-2 Infection"},"content":{"rendered":"<ul>\n<li>A prospective serology cohort study among UK healthcare workers found that by 21 weeks, 22% (31 of 143) of those previously positive for anti-SARS-CoV-2 spike (S1) antibodies reverted to being S1 negative, while only 4% (6 of 150) of those previously positive for anti-SARS-CoV-2 nucleocapsid (NP) antibodies reverted to being NP negative, which the authors suggest may indicate that anti-S mediated humoral immunity in some individuals may not persist long after the initial post-infection period. Additionally, while both anti-S1 and anti-NP measurements correlated well, only anti-S1 measurements correlated with neutralizing antibody titers. Mathematical modelling showed that anti-S1 antibodies cleared faster compared to anti-NP antibodies (median half-life 2.5 weeks vs 4 weeks), transitioned earlier to decreased antibody production (median 8 vs 13 weeks), and had lower relative production rates after the transition (median 35% vs 50%).<\/li>\n<\/ul>\n<p><i>Manisty et al.\u00a0(Mar 2, 2021). Time Series Analysis and Mechanistic Modelling of Heterogeneity and Sero-Reversion in Antibody Responses to Mild SARS-CoV-2 Infection. EBioMedicine. <\/i><a href=\"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103259\">https:\/\/doi.org\/10.1016\/j.ebiom.2021.103259<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A prospective serology cohort study among UK healthcare workers found that by 21 weeks, 22% (31 of 143) of those previously positive for anti-SARS-CoV-2 spike (S1) antibodies reverted to being S1 negative, while only 4% (6 of 150) of those previously positive for anti-SARS-CoV-2 nucleocapsid (NP) antibodies reverted to being NP negative, which the authors&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/05\/time-series-analysis-and-mechanistic-modelling-of-heterogeneity-and-sero-reversion-in-antibody-responses-to-mild-sars-cov-2-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,32],"topic":[31],"class_list":["post-5982","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5982","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=5982"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5982\/revisions"}],"predecessor-version":[{"id":5983,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5982\/revisions\/5983"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=5982"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=5982"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=5982"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=5982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}