{"id":6062,"date":"2021-03-08T17:51:18","date_gmt":"2021-03-09T01:51:18","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6062"},"modified":"2021-03-08T17:51:18","modified_gmt":"2021-03-09T01:51:18","slug":"the-emergence-and-ongoing-convergent-evolution-of-the-n501y-lineages-coincides-with-a-major-global-shift-in-the-sars-cov-2-selective-landscap","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/08\/the-emergence-and-ongoing-convergent-evolution-of-the-n501y-lineages-coincides-with-a-major-global-shift-in-the-sars-cov-2-selective-landscap\/","title":{"rendered":"The Emergence and Ongoing Convergent Evolution of the N501Y Lineages Coincides with a Major Global Shift in the SARS-CoV-2 Selective Landscap"},"content":{"rendered":"<ul>\n<li><i>[Pre-print, not peer-reviewed]<\/i> A study examining patterns of SARS-CoV-2 mutations via phylogenetics-based analyses found evidence for changes in the selective pressures of specific SARS-CoV-2 genes (such as N and S) that likely coincided with the emergence of the three main 501Y lineages (B.1.1.7, B.1.351, P.1). The analysis included all SARS-CoV-2 sequences in GISAID assigned to these three lineages by Feb 2, 2021. The authors found a significant shift in selective pressures occurred around November 2020. In addition, a significant portion of the ongoing adaptive evolution of these lineages seemed to involve further convergence between them, suggesting that viruses in these distinct lineages may be converging on a similar adaptive endpoint.<\/li>\n<\/ul>\n<p><i>Martin et al.\u00a0(Mar 5, 2021). The Emergence and Ongoing Convergent Evolution of the N501Y Lineages Coincides with a Major Global Shift in the SARS-CoV-2 Selective Landscape. Pre-print downloaded Mar 8 from <\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.02.23.21252268\">https:\/\/doi.org\/10.1101\/2021.02.23.21252268<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] A study examining patterns of SARS-CoV-2 mutations via phylogenetics-based analyses found evidence for changes in the selective pressures of specific SARS-CoV-2 genes (such as N and S) that likely coincided with the emergence of the three main 501Y lineages (B.1.1.7, B.1.351, P.1). The analysis included all SARS-CoV-2 sequences in GISAID assigned to&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/08\/the-emergence-and-ongoing-convergent-evolution-of-the-n501y-lineages-coincides-with-a-major-global-shift-in-the-sars-cov-2-selective-landscap\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[159],"topic":[24],"class_list":["post-6062","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-variants","topic-geographic-spread"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6062","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6062"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6062\/revisions"}],"predecessor-version":[{"id":6063,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6062\/revisions\/6063"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6062"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6062"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6062"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6062"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}