{"id":6074,"date":"2021-03-08T17:57:41","date_gmt":"2021-03-09T01:57:41","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6074"},"modified":"2021-03-08T17:57:41","modified_gmt":"2021-03-09T01:57:41","slug":"robust-sars-cov-2-specific-t-cell-immunity-is-maintained-at-6-months-following-primary-infection-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/08\/robust-sars-cov-2-specific-t-cell-immunity-is-maintained-at-6-months-following-primary-infection-2\/","title":{"rendered":"Robust SARS-CoV-2-Specific T Cell Immunity Is Maintained at 6 Months Following Primary Infection"},"content":{"rendered":"<ul>\n<li>Functional SARS-CoV-2-specific T cell responses were retained 6 months after initial SARS-CoV-2 infection among 100 convalescent donors between March and April 2020. Interferon (IFN)-\u03b3 ELISPOT analysis was used to determine the magnitude of the T cell response. Cell responses were present among all donors and characterized by predominant CD4+ T cell responses with strong interleukin (IL)-2 cytokine expression. Median T cell responses were 50% higher in donors who had an initial symptomatic infection, and T cell responses to spike and nucleoprotein\/membrane proteins correlated with peak antibody levels. In addition, higher levels of nucleoprotein-specific T cells were associated with preservation of nucleoprotein-specific antibody level.<\/li>\n<\/ul>\n<p><i>Zuo et al.\u00a0(Mar 5, 2021). Robust SARS-CoV-2-Specific T Cell Immunity Is Maintained at 6 Months Following Primary Infection. Nature Immunology. <\/i><a href=\"https:\/\/doi.org\/10.1038\/s41590-021-00902-8\">https:\/\/doi.org\/10.1038\/s41590-021-00902-8<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Functional SARS-CoV-2-specific T cell responses were retained 6 months after initial SARS-CoV-2 infection among 100 convalescent donors between March and April 2020. Interferon (IFN)-\u03b3 ELISPOT analysis was used to determine the magnitude of the T cell response. Cell responses were present among all donors and characterized by predominant CD4+ T cell responses with strong interleukin&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/08\/robust-sars-cov-2-specific-t-cell-immunity-is-maintained-at-6-months-following-primary-infection-2\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-6074","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6074","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6074"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6074\/revisions"}],"predecessor-version":[{"id":6075,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6074\/revisions\/6075"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6074"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6074"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6074"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6074"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}