{"id":6119,"date":"2020-04-17T14:17:14","date_gmt":"2020-04-17T21:17:14","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6119"},"modified":"2021-03-09T14:18:19","modified_gmt":"2021-03-09T22:18:19","slug":"delayed-clearance-of-sars-cov-2-in-male-compared-to-female-patients-high-ace2-expression-in-testes-suggests-possible-existence-of-gender-specific-viral-reservoirs","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/04\/17\/delayed-clearance-of-sars-cov-2-in-male-compared-to-female-patients-high-ace2-expression-in-testes-suggests-possible-existence-of-gender-specific-viral-reservoirs\/","title":{"rendered":"Delayed clearance of SARS-CoV-2 in male compared to female patients: High ACE2 expression in testes suggests possible existence of gender-specific viral reservoirs"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">In this study, the authors evaluate the time to viral clearance in 68 symptomatic patients (71% males and 29% females), and report that females achieved viral clearance significantly earlier than males, with a median difference of 2 days.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Shastri et al hypothesize that high expression of ACE2 in testes could indicate that testicular viral reservoirs may play a role in viral persistence, and this could have important implications for understanding the transmission and persistence of SARS-CoV-2.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Shastri et al. (Apr 17, 2020). Delayed clearance of SARS-CoV-2 in male compared to female patients: High ACE2 expression in testes suggests possible existence of gender-specific viral reservoirs. Pre-print downloaded Apr 17 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.04.16.20060566\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2020.04.16.20060566<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this study, the authors evaluate the time to viral clearance in 68 symptomatic patients (71% males and 29% females), and report that females achieved viral clearance significantly earlier than males, with a median difference of 2 days.\u00a0 Shastri et al hypothesize that high expression of ACE2 in testes could indicate that testicular viral reservoirs&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/04\/17\/delayed-clearance-of-sars-cov-2-in-male-compared-to-female-patients-high-ace2-expression-in-testes-suggests-possible-existence-of-gender-specific-viral-reservoirs\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[21],"class_list":["post-6119","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6119","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6119"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6119\/revisions"}],"predecessor-version":[{"id":6120,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6119\/revisions\/6120"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6119"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6119"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6119"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}