{"id":6152,"date":"2020-04-20T14:41:27","date_gmt":"2020-04-20T21:41:27","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6152"},"modified":"2021-03-09T14:42:35","modified_gmt":"2021-03-09T22:42:35","slug":"the-scrna-seq-expression-profiling-of-the-receptor-ace2-and-the-cellular-protease-tmprss2-reveals-human-organs-susceptible-to-covid19-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/04\/20\/the-scrna-seq-expression-profiling-of-the-receptor-ace2-and-the-cellular-protease-tmprss2-reveals-human-organs-susceptible-to-covid19-infection\/","title":{"rendered":"The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID19 infection"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">This study found evidence of COVID-19 infection in the nervous, digestive, reproductive, respiratory, circulatory and urine systems using scRNA-Seq data collected from 31 organs from 9 major human systems. The lungs, large intestine, fallopian tube and nose were found to be the most susceptible organs, indicating that SARS-CoV-2 mainly attacks the respiratory, digestive and reproductive systems.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Studying viral susceptibility of multiple organs can aid clinical diagnosis and treatment of patients and contribute to a deeper understanding of viral pathogenesis.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Qi et al. (Apr 18, 2020). The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID19 infection. Pre-print downloaded Apr 20 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.04.16.045690\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2020.04.16.045690<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This study found evidence of COVID-19 infection in the nervous, digestive, reproductive, respiratory, circulatory and urine systems using scRNA-Seq data collected from 31 organs from 9 major human systems. The lungs, large intestine, fallopian tube and nose were found to be the most susceptible organs, indicating that SARS-CoV-2 mainly attacks the respiratory, digestive and reproductive&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/04\/20\/the-scrna-seq-expression-profiling-of-the-receptor-ace2-and-the-cellular-protease-tmprss2-reveals-human-organs-susceptible-to-covid19-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-6152","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6152","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6152"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6152\/revisions"}],"predecessor-version":[{"id":6153,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6152\/revisions\/6153"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6152"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6152"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6152"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}