{"id":6186,"date":"2020-04-21T15:25:56","date_gmt":"2020-04-21T22:25:56","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6186"},"modified":"2021-03-09T15:26:49","modified_gmt":"2021-03-09T23:26:49","slug":"specific-ace2-expression-in-small-intestinal-enterocytes-may-cause-gastrointestinal-symptoms-and-injury-after-2019-ncov-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/04\/21\/specific-ace2-expression-in-small-intestinal-enterocytes-may-cause-gastrointestinal-symptoms-and-injury-after-2019-ncov-infection\/","title":{"rendered":"Specific ACE2 Expression in Small Intestinal Enterocytes may Cause Gastrointestinal Symptoms and Injury after 2019-nCoV Infection"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">This study summarizes clinical data from four recent studies involving clinical characteristics of COVID-19 to determine the incidence of GI symptoms and explore the potential mechanism of diarrhea and other GI manifestations of disease.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Results reveal that ACE mRNA and proteins are highly expressed in the small intestine, which may mediate the invasion and amplification of SARS-CoV-2 and activation of GI inflammation.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Zhang et al. (April 18, 2020). Specific ACE2 Expression in Small Intestinal Enterocytes may Cause <\/span><\/i><i><span style=\"font-weight: 400\">Gastrointestinal Symptoms and Injury after 2019-nCoV Infection. Int J Infect Dis. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.ijid.2020.04.027\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/j.ijid.2020.04.027<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This study summarizes clinical data from four recent studies involving clinical characteristics of COVID-19 to determine the incidence of GI symptoms and explore the potential mechanism of diarrhea and other GI manifestations of disease. Results reveal that ACE mRNA and proteins are highly expressed in the small intestine, which may mediate the invasion and amplification&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/04\/21\/specific-ace2-expression-in-small-intestinal-enterocytes-may-cause-gastrointestinal-symptoms-and-injury-after-2019-ncov-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-6186","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6186"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6186\/revisions"}],"predecessor-version":[{"id":6187,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6186\/revisions\/6187"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6186"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6186"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6186"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}