{"id":6396,"date":"2021-03-10T21:43:02","date_gmt":"2021-03-11T05:43:02","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6396"},"modified":"2021-03-10T21:43:02","modified_gmt":"2021-03-11T05:43:02","slug":"transmission-infectivity-and-antibody-neutralization-of-an-emerging-sars-cov-2-variant-in-california-carrying-a-l452r-spike-protein-mutation","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/10\/transmission-infectivity-and-antibody-neutralization-of-an-emerging-sars-cov-2-variant-in-california-carrying-a-l452r-spike-protein-mutation\/","title":{"rendered":"Transmission Infectivity and Antibody Neutralization of an Emerging SARS-CoV-2 Variant in California Carrying a L452R Spike Protein Mutation"},"content":{"rendered":"<ul>\n<li><i>[Pre-print, not peer-reviewed]<\/i> Whole genome sequencing of 2,172 remnant nasal\/nasopharyngeal swab samples from 44 counties in California identified a novel SARS-CoV-2 variant characterized by three mutations in the spike protein named B.1.427\/B.1.429 or 20C\/L452R. This variant emerged around May 2020, and by January 29, 2021 represented &gt;50% of sequenced cases, exhibiting an estimated 19-24% increase in transmissibility relative to circulating wild-type strains.\u00a0Antibody neutralization assays showed 4.0-6.7-fold decreases in neutralizing titers from convalescent patients and 2.0-fold decreases in vaccine recipients.<\/li>\n<\/ul>\n<p><i>Deng et al.\u00a0(Mar 9, 2021). Transmission Infectivity and Antibody Neutralization of an Emerging SARS-CoV-2 Variant in California Carrying a L452R Spike Protein Mutation. Pre-print downloaded Mar 10 from <\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.03.07.21252647\">https:\/\/doi.org\/10.1101\/2021.03.07.21252647<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Whole genome sequencing of 2,172 remnant nasal\/nasopharyngeal swab samples from 44 counties in California identified a novel SARS-CoV-2 variant characterized by three mutations in the spike protein named B.1.427\/B.1.429 or 20C\/L452R. This variant emerged around May 2020, and by January 29, 2021 represented &gt;50% of sequenced cases, exhibiting an estimated 19-24% increase&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/10\/transmission-infectivity-and-antibody-neutralization-of-an-emerging-sars-cov-2-variant-in-california-carrying-a-l452r-spike-protein-mutation\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[38,159],"topic":[21],"class_list":["post-6396","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-transmission","tag-variants","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6396","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6396"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6396\/revisions"}],"predecessor-version":[{"id":6397,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6396\/revisions\/6397"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6396"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6396"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6396"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}