{"id":6400,"date":"2021-03-10T21:44:47","date_gmt":"2021-03-11T05:44:47","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6400"},"modified":"2021-03-10T21:44:47","modified_gmt":"2021-03-11T05:44:47","slug":"the-plasmablast-response-to-sars-cov-2-mrna-vaccination-is-dominated-by-non-neutralizing-antibodies-that-target-both-the-ntd-and-the-rbd","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/10\/the-plasmablast-response-to-sars-cov-2-mrna-vaccination-is-dominated-by-non-neutralizing-antibodies-that-target-both-the-ntd-and-the-rbd\/","title":{"rendered":"The Plasmablast Response to SARS-CoV-2 MRNA Vaccination Is Dominated by Non-Neutralizing Antibodies That Target Both the NTD and the RBD"},"content":{"rendered":"<ul>\n<li><i>[Pre-print, not peer-reviewed]<\/i> A study of vaccine-induced polyclonal antibodies and monoclonal antibodies (mAbs) from subjects who received SARS-CoV-2 mRNA vaccines found that polyclonal antibody responses were robust and comparable to or exceeded those observed after natural infection. However, most vaccine-induced mAbs did not demonstrate neutralizing activity. Neutralizing activity of N-terminal domain (NTD) mAbs, but not receptor binding domain (RBD) mAbs, against a virus carrying the E484K substitution and extensive changes in the NTD was abolished, which the authors indicate suggests that some vaccine-induced RBD-binding antibodies may protect against viral variants carrying E484K.<\/li>\n<\/ul>\n<p><i>Amanat et al.\u00a0(Mar 9, 2021). The Plasmablast Response to SARS-CoV-2 MRNA Vaccination Is Dominated by Non-Neutralizing Antibodies That Target Both the NTD and the RBD. Pre-print downloaded Mar 10 from <\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.03.07.21253098\">https:\/\/doi.org\/10.1101\/2021.03.07.21253098<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] A study of vaccine-induced polyclonal antibodies and monoclonal antibodies (mAbs) from subjects who received SARS-CoV-2 mRNA vaccines found that polyclonal antibody responses were robust and comparable to or exceeded those observed after natural infection. However, most vaccine-induced mAbs did not demonstrate neutralizing activity. Neutralizing activity of N-terminal domain (NTD) mAbs, but not&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/10\/the-plasmablast-response-to-sars-cov-2-mrna-vaccination-is-dominated-by-non-neutralizing-antibodies-that-target-both-the-ntd-and-the-rbd\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,142,159],"topic":[31],"class_list":["post-6400","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-vaccine","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6400","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6400"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6400\/revisions"}],"predecessor-version":[{"id":6401,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6400\/revisions\/6401"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6400"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}