{"id":6433,"date":"2021-03-11T20:53:04","date_gmt":"2021-03-12T04:53:04","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6433"},"modified":"2021-03-11T20:53:04","modified_gmt":"2021-03-12T04:53:04","slug":"immune-response-to-sars-cov-2-variants-of-concern-in-vaccinated-individuals","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/11\/immune-response-to-sars-cov-2-variants-of-concern-in-vaccinated-individuals\/","title":{"rendered":"Immune Response to SARS-CoV-2 Variants of Concern in Vaccinated Individuals"},"content":{"rendered":"<ul>\n<li><i>[Pre-print, not peer-reviewed]<\/i> Sera from both individuals with prior SARS-CoV-2 infection (n=35) and individuals fully vaccinated with the Pfizer-BioNTech vaccine (n=23) showed nearly identical antibody binding responses against the B.1.1.7 Cluster 5 and CAL.20C variants compared to wild-type SARS-CoV-2. In contrast, both binding and neutralizing antibody responses among vaccinated individuals were diminished against the B.1.351 variant compared to wild-type SARS-CoV-2, although the 2nd vaccine dose appeared to confer increased neutralization capacities. In a separate analysis, the authors found that individuals with prior SARS-CoV-2 infection had higher IgA antibody titers in saliva, while vaccinated individuals had high IgG titers.<\/li>\n<\/ul>\n<p><i>Becker et al.\u00a0(Mar 10, 2021). Immune Response to SARS-CoV-2 Variants of Concern in Vaccinated Individuals. Pre-print downloaded Mar 11 from <\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.03.08.21252958\">https:\/\/doi.org\/10.1101\/2021.03.08.21252958<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Sera from both individuals with prior SARS-CoV-2 infection (n=35) and individuals fully vaccinated with the Pfizer-BioNTech vaccine (n=23) showed nearly identical antibody binding responses against the B.1.1.7 Cluster 5 and CAL.20C variants compared to wild-type SARS-CoV-2. In contrast, both binding and neutralizing antibody responses among vaccinated individuals were diminished against the B.1.351&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/11\/immune-response-to-sars-cov-2-variants-of-concern-in-vaccinated-individuals\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-6433","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6433","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6433"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6433\/revisions"}],"predecessor-version":[{"id":6434,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6433\/revisions\/6434"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6433"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6433"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6433"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6433"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}