{"id":6470,"date":"2020-04-30T15:02:28","date_gmt":"2020-04-30T22:02:28","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6470"},"modified":"2021-03-12T15:03:16","modified_gmt":"2021-03-12T23:03:16","slug":"modelling-of-systemic-versus-pulmonary-chloroquine-exposure-in-man-for-covid-19-dose-selection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/04\/30\/modelling-of-systemic-versus-pulmonary-chloroquine-exposure-in-man-for-covid-19-dose-selection\/","title":{"rendered":"Modelling of Systemic versus Pulmonary Chloroquine Exposure in Man for COVID-19 Dose Selection"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">This study explores the pharmacokinetic-pharmacodynamic (PK-PD) relationship of chloroquine (CQ) for COVID-19 by modeling both achievable systemic and pulmonary drug concentrations.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">CQ is unlikely to achieve systemic levels that would exert meaningful anti-viral activity given its in-vitro pharmacodynamics profile. However, if lung exposure is the driver for CQ\u2019s activity, the simulations shows that currently suggested dosages can be substantially lowered for therapy or prophylaxis.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Aljayyoussi et al. (Apr 30, 2020). Modelling of Systemic versus Pulmonary Chloroquine Exposure in Man for COVID-19 Dose Selection. Pre-print downloaded Apr 30 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.04.24.20078741\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2020.04.24.20078741<\/span><\/a><i><span style=\"font-weight: 400\">\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This study explores the pharmacokinetic-pharmacodynamic (PK-PD) relationship of chloroquine (CQ) for COVID-19 by modeling both achievable systemic and pulmonary drug concentrations.\u00a0 CQ is unlikely to achieve systemic levels that would exert meaningful anti-viral activity given its in-vitro pharmacodynamics profile. However, if lung exposure is the driver for CQ\u2019s activity, the simulations shows that currently suggested&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/04\/30\/modelling-of-systemic-versus-pulmonary-chloroquine-exposure-in-man-for-covid-19-dose-selection\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-6470","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6470"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6470\/revisions"}],"predecessor-version":[{"id":6471,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6470\/revisions\/6471"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6470"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}