{"id":6504,"date":"2020-05-01T15:42:48","date_gmt":"2020-05-01T22:42:48","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6504"},"modified":"2021-03-12T15:43:41","modified_gmt":"2021-03-12T23:43:41","slug":"addressing-multiple-gastroenterological-aspects-of-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/01\/addressing-multiple-gastroenterological-aspects-of-covid-19\/","title":{"rendered":"Addressing multiple gastroenterological aspects of COVID-19"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Eder et al. review current evidence of gastrointestinal (GI) involvement in patients with SARS-CoV-2 infection. Approximately 10% of COVID-19 cases experience GI symptoms that precede respiratory symptoms and fever, and 50% of all cases report GI symptoms. Although there is growing evidence that GI manifestations are an important clinical characteristic, the mechanisms remain unclear.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Although there is evidence of detection of RNA in stool (including after tests from oral or nasopharyngeal swabs are negative), there is currently no evidence of fecal-oral transmission.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">There is some evidence that patients with diarrhea have more severe symptoms of pneumonia.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Pathogenesis may be explained by the expression of angiotensin converting enzyme 2 (ACE2) proteins along the respiratory and gastrointestinal tracts. SARS-CoV-2 has a high affinity to ACE2 proteins, which serve as an entry receptor for SARS-CoV-2.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Eder et al. (May 1, 2020). Addressing multiple gastroenterological aspects of COVID-19. Polish Archives of Internal Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.20452\/pamw.15332\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.20452\/pamw.15332<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Eder et al. review current evidence of gastrointestinal (GI) involvement in patients with SARS-CoV-2 infection. Approximately 10% of COVID-19 cases experience GI symptoms that precede respiratory symptoms and fever, and 50% of all cases report GI symptoms. Although there is growing evidence that GI manifestations are an important clinical characteristic, the mechanisms remain unclear. Although&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/01\/addressing-multiple-gastroenterological-aspects-of-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[21],"class_list":["post-6504","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6504"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6504\/revisions"}],"predecessor-version":[{"id":6505,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6504\/revisions\/6505"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6504"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}