{"id":6506,"date":"2020-05-01T15:43:47","date_gmt":"2020-05-01T22:43:47","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6506"},"modified":"2021-03-12T15:44:35","modified_gmt":"2021-03-12T23:44:35","slug":"estimating-seroprevalence-with-imperfect-serological-tests-a-cutoff-free-approach","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/01\/estimating-seroprevalence-with-imperfect-serological-tests-a-cutoff-free-approach\/","title":{"rendered":"Estimating Seroprevalence with Imperfect Serological Tests: A Cutoff-Free Approach"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Serological tests, which measure antibody responses against pathogens, are useful for retroactively determining the total number of cumulative SARS-CoV-2 infections that have occurred within a population (i.e. seroprevalence). Bouman et al. propose a likelihood-based method for estimating population-level seroprevalence that may overcome the deficits of serological tests for SARS-CoV-2 with low sensitivity. They use simulations to explore the performance of their method, compared to traditional threshold-based measures that dichotomized serological antibody measurements as &#8220;positive&#8221; or &#8220;negative&#8221; using a cutoff value.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Bouman et al. (April 30, 2020). Estimating Seroprevalence with Imperfect Serological Tests: A Cutoff-Free Approach. Pre-print downloaded May 1 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.04.29.068999\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2020.04.29.068999<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Serological tests, which measure antibody responses against pathogens, are useful for retroactively determining the total number of cumulative SARS-CoV-2 infections that have occurred within a population (i.e. seroprevalence). Bouman et al. propose a likelihood-based method for estimating population-level seroprevalence that may overcome the deficits of serological tests for SARS-CoV-2 with low sensitivity. They use simulations&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/01\/estimating-seroprevalence-with-imperfect-serological-tests-a-cutoff-free-approach\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-6506","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6506"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6506\/revisions"}],"predecessor-version":[{"id":6507,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6506\/revisions\/6507"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6506"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}