{"id":6609,"date":"2020-05-04T14:19:59","date_gmt":"2020-05-04T21:19:59","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6609"},"modified":"2021-03-16T14:20:56","modified_gmt":"2021-03-16T21:20:56","slug":"remdesivir-in-adults-with-severe-covid-19%e2%80%af-a-randomised-double-blind-placebo-controlled-multicentre-trial","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/04\/remdesivir-in-adults-with-severe-covid-19%e2%80%af-a-randomised-double-blind-placebo-controlled-multicentre-trial\/","title":{"rendered":"Remdesivir\u00a0in Adults with Severe COVID-19\u202f:\u00a0A\u00a0Randomised, double-blind, placebo-controlled,\u00a0multicentre\u00a0trial"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"38\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A randomized, double-blind, placebo controlled multicent<\/span><span data-contrast=\"auto\">er<\/span><span data-contrast=\"auto\">\u00a0trial at ten hospitals in Hubei, China<\/span><span data-contrast=\"auto\">\u00a0with 237 participants (158 randomized to\u00a0remdesivir, 79 to placebo) demonstrated that time to clinical improvement<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">did not differ\u00a0<\/span><span data-contrast=\"auto\">by study arm, with 21 days (<\/span><span data-contrast=\"auto\">IQR\u00a0<\/span><span data-contrast=\"auto\">13-28<\/span><span data-contrast=\"auto\">\u00a0days<\/span><span data-contrast=\"auto\">) in the\u00a0<\/span><span data-contrast=\"auto\">remdesivir\u00a0<\/span><span data-contrast=\"auto\">group<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">versus 23 days (<\/span><span data-contrast=\"auto\">IQR\u00a0<\/span><span data-contrast=\"auto\">15-28<\/span><span data-contrast=\"auto\">\u00a0days<\/span><span data-contrast=\"auto\">) in the placebo group (HR 1.23<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">95%<\/span><span data-contrast=\"auto\">\u00a0CI 0.87 \u2013 1.75)<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Overall frequency of a<\/span><span data-contrast=\"auto\">d<\/span><span data-contrast=\"auto\">verse events w<\/span><span data-contrast=\"auto\">as<\/span><span data-contrast=\"auto\">\u00a0similar in both groups<\/span><span data-contrast=\"auto\">;\u00a0<\/span><span data-contrast=\"auto\">however\u00a0treatment cessation due to adverse events was higher in the\u00a0remdesivir\u00a0(12%) than placebo (5%) group.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Wang et al. (<\/span><\/i><i><span data-contrast=\"none\">Apr 29,\u00a0<\/span><\/i><i><span data-contrast=\"none\">2020).\u00a0Remdesivir\u00a0in Adults with Severe COVID-19\u202f:\u00a0A\u00a0Randomised, double-blind, placebo-controlled,\u00a0multicentre\u00a0trial. The Lancet<\/span><\/i><i><span data-contrast=\"auto\">.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(20)31022-9\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/S0140-6736(20)31022-9<\/span><\/i><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A randomized, double-blind, placebo controlled multicenter\u00a0trial at ten hospitals in Hubei, China\u00a0with 237 participants (158 randomized to\u00a0remdesivir, 79 to placebo) demonstrated that time to clinical improvement\u00a0did not differ\u00a0by study arm, with 21 days (IQR\u00a013-28\u00a0days) in the\u00a0remdesivir\u00a0group\u00a0versus 23 days (IQR\u00a015-28\u00a0days) in the placebo group (HR 1.23,\u00a095%\u00a0CI 0.87 \u2013 1.75).\u00a0Overall frequency of adverse events was\u00a0similar in both&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/04\/remdesivir-in-adults-with-severe-covid-19%e2%80%af-a-randomised-double-blind-placebo-controlled-multicentre-trial\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-6609","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6609"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6609\/revisions"}],"predecessor-version":[{"id":6610,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6609\/revisions\/6610"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6609"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6609"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6609"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}