{"id":6615,"date":"2020-05-04T14:23:27","date_gmt":"2020-05-04T21:23:27","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6615"},"modified":"2021-03-16T14:24:15","modified_gmt":"2021-03-16T21:24:15","slug":"longitudinal-change-of-sars-cov2-antibodies-in-patients-with-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/04\/longitudinal-change-of-sars-cov2-antibodies-in-patients-with-covid-19\/","title":{"rendered":"Longitudinal Change of SARS-Cov2 Antibodies in Patients with COVID-19"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"38\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Antibody tests designed to detect envelope protein E and nucleocapsid protein N were conducted on 112 COVID-19\u00a0<\/span><span data-contrast=\"auto\">(PCR positive)\u00a0<\/span><span data-contrast=\"auto\">patients admitted to a hospital in Wuhan<\/span><span data-contrast=\"auto\">, China<\/span><span data-contrast=\"auto\">\u00a0in February 2020.\u00a0<\/span><span data-contrast=\"auto\">One hundred and five (93<\/span><span data-contrast=\"auto\">.8%) were positive for\u00a0<\/span><span data-contrast=\"auto\">either IgM<\/span><span data-contrast=\"auto\">, IgG,\u00a0<\/span><span data-contrast=\"auto\">or\u00a0<\/span><span data-contrast=\"auto\">both.<\/span><span data-contrast=\"auto\">\u00a0T<\/span><span data-contrast=\"auto\">iming of testing with respect to disease onset varied<\/span><span data-contrast=\"auto\">, and was\u00a0<\/span><span data-contrast=\"auto\">less than<\/span><span data-contrast=\"auto\">\u00a010 days (i.e., possibly prior to antibody production) for 7 participants<\/span><span data-contrast=\"auto\">\u00a0(two of whom were negative to both<\/span><span data-contrast=\"auto\">\u00a0IgM and IgG<\/span><span data-contrast=\"auto\">).<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">IgM\u00a0<\/span><span data-contrast=\"auto\">and<\/span><span data-contrast=\"auto\">\u00a0IgG\u00a0<\/span><span data-contrast=\"auto\">titers\u00a0<\/span><span data-contrast=\"auto\">did not differ\u00a0<\/span><span data-contrast=\"auto\">between\u00a0<\/span><span data-contrast=\"auto\">those<\/span><span data-contrast=\"auto\">\u00a0who were PCR negative versus positive after treatment.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Zhang et al. (May<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><i><span data-contrast=\"none\">2<\/span><\/i><i><span data-contrast=\"none\">, 2020). Longitudinal Change of SARS-Cov2 Antibodies in Patients with COVID-19. The Journal of Infectious Diseases<\/span><\/i><i><span data-contrast=\"auto\">.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/infdis\/jiaa229\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1093\/infdis\/jiaa229<\/span><\/i><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antibody tests designed to detect envelope protein E and nucleocapsid protein N were conducted on 112 COVID-19\u00a0(PCR positive)\u00a0patients admitted to a hospital in Wuhan, China\u00a0in February 2020.\u00a0One hundred and five (93.8%) were positive for\u00a0either IgM, IgG,\u00a0or\u00a0both.\u00a0Timing of testing with respect to disease onset varied, and was\u00a0less than\u00a010 days (i.e., possibly prior to antibody production) for&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/04\/longitudinal-change-of-sars-cov2-antibodies-in-patients-with-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-6615","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6615"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6615\/revisions"}],"predecessor-version":[{"id":6616,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6615\/revisions\/6616"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6615"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}