{"id":6693,"date":"2020-05-07T15:42:59","date_gmt":"2020-05-07T22:42:59","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6693"},"modified":"2021-03-16T15:43:54","modified_gmt":"2021-03-16T22:43:54","slug":"identification-of-igg-antibody-response-to-sars-cov-2-spike-protein-and-its-receptor-binding-domain-does-not-predict-rapid-recovery-from-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/07\/identification-of-igg-antibody-response-to-sars-cov-2-spike-protein-and-its-receptor-binding-domain-does-not-predict-rapid-recovery-from-covid-19\/","title":{"rendered":"Identification of IgG Antibody Response to SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Does Not Predict Rapid Recovery from COVID-19"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Q<\/span><span data-contrast=\"none\">uanti<\/span><span data-contrast=\"none\">fication of<\/span><span data-contrast=\"none\">\u00a0SARS-CoV-2 antibody response<\/span><span data-contrast=\"none\">s from 20 hospitalized patient with confirmed\u00a0<\/span><span data-contrast=\"none\">SARS-CoV-2<\/span><span data-contrast=\"none\">\u00a0infection found that the\u00a0<\/span><span data-contrast=\"none\">IgG titers against SARS-CoV-2 spike glycoprotein and\u00a0<\/span><span data-contrast=\"none\">its\u00a0<\/span><span data-contrast=\"none\">receptor binding domain<\/span><span data-contrast=\"none\">\u00a0(RBD)<\/span><span data-contrast=\"none\">\u00a0were not associated with\u00a0<\/span><span data-contrast=\"none\">their\u00a0<\/span><span data-contrast=\"none\">speed of recovery<\/span><span data-contrast=\"none\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">O<\/span><span data-contrast=\"none\">ne patient who recovered completely did not develop RBD antibodies. The authors note that COVID-19 immunity may involve cell-mediated (adaptive T-cell) as well as humoral (antibody) immunity.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">McAndrews<\/span><\/i><i><span data-contrast=\"none\">\u00a0et al<\/span><\/i><i><span data-contrast=\"none\">. (May 6, 2020). Identification of IgG Antibody Response to SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Does Not Predict Rapid Recovery from COVID-19.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print downloaded May 7 from<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.01.20087684\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.01.20087684<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Quantification of\u00a0SARS-CoV-2 antibody responses from 20 hospitalized patient with confirmed\u00a0SARS-CoV-2\u00a0infection found that the\u00a0IgG titers against SARS-CoV-2 spike glycoprotein and\u00a0its\u00a0receptor binding domain\u00a0(RBD)\u00a0were not associated with\u00a0their\u00a0speed of recovery.\u00a0 One patient who recovered completely did not develop RBD antibodies. The authors note that COVID-19 immunity may involve cell-mediated (adaptive T-cell) as well as humoral (antibody) immunity.\u00a0\u00a0 McAndrews\u00a0et al&#8230;.<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/07\/identification-of-igg-antibody-response-to-sars-cov-2-spike-protein-and-its-receptor-binding-domain-does-not-predict-rapid-recovery-from-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-6693","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6693","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6693"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6693\/revisions"}],"predecessor-version":[{"id":6694,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6693\/revisions\/6694"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6693"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6693"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6693"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}