{"id":6705,"date":"2020-05-08T15:50:39","date_gmt":"2020-05-08T22:50:39","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6705"},"modified":"2021-03-16T15:51:26","modified_gmt":"2021-03-16T22:51:26","slug":"viral-kinetics-of-sars-cov-2-in-asymptomatic-carriers-and-presymptomatic-patients","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/08\/viral-kinetics-of-sars-cov-2-in-asymptomatic-carriers-and-presymptomatic-patients\/","title":{"rendered":"Viral Kinetics of SARS-CoV-2 in Asymptomatic Carriers and\u00a0Presymptomatic\u00a0Patients"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Kim et al. included 71\u00a0<\/span><span data-contrast=\"auto\">participants with\u00a0<\/span><span data-contrast=\"auto\">laboratory-confirmed\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2 infection who were hospitalized for treatment or isolation<\/span><span data-contrast=\"auto\">\u00a0and found\u00a0<\/span><span data-contrast=\"auto\">that\u00a0<\/span><span data-contrast=\"auto\">3 were pre-symptomatic and 10 were entirely asymptomatic. Two of the three pre-symptomatic patients had\u00a0<\/span><span data-contrast=\"auto\">very high level<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">\u00a0of\u00a0<\/span><span data-contrast=\"auto\">vir<\/span><span data-contrast=\"auto\">us<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">present<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">during\u00a0<\/span><span data-contrast=\"auto\">the\u00a0<\/span><span data-contrast=\"auto\">incubation<\/span><span data-contrast=\"auto\">\u00a0period (Ct value &lt;20).\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">The median\u00a0<\/span><span data-contrast=\"auto\">time until\u00a0<\/span><span data-contrast=\"auto\">the first negative RT-PCR (Ct &gt;35) in the entirely asymptomatic carriers was 4.5 (range 2.5-9) days, and all asymptomatic carriers reached the first negative within 14 days after diagnosis. Patients who have COVID-19 may already be infectious before\u00a0<\/span><span data-contrast=\"auto\">they exhibit\u00a0<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">ymptoms, and 14 days of isolation after diagnosis may be sufficient in entirely asymptomatic cases<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Kim et al. (May 3, 2020). Viral Kinetics of SARS-CoV-2 in Asymptomatic Carriers and\u00a0<\/span><\/i><i><span data-contrast=\"none\">Presymptomatic<\/span><\/i><i><span data-contrast=\"none\">\u00a0Patients. International Journal of Infectious Diseases.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.ijid.2020.04.083\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.ijid.2020.04.083<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kim et al. included 71\u00a0participants with\u00a0laboratory-confirmed\u00a0SARS-CoV-2 infection who were hospitalized for treatment or isolation\u00a0and found\u00a0that\u00a03 were pre-symptomatic and 10 were entirely asymptomatic. Two of the three pre-symptomatic patients had\u00a0very high levels\u00a0of\u00a0virus\u00a0present\u00a0during\u00a0the\u00a0incubation\u00a0period (Ct value &lt;20).\u00a0\u00a0 The median\u00a0time until\u00a0the first negative RT-PCR (Ct &gt;35) in the entirely asymptomatic carriers was 4.5 (range 2.5-9) days, and all asymptomatic&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/08\/viral-kinetics-of-sars-cov-2-in-asymptomatic-carriers-and-presymptomatic-patients\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[21],"class_list":["post-6705","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6705","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6705"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6705\/revisions"}],"predecessor-version":[{"id":6706,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6705\/revisions\/6706"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6705"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6705"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6705"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6705"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}