{"id":6711,"date":"2020-05-08T15:53:25","date_gmt":"2020-05-08T22:53:25","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6711"},"modified":"2021-03-16T15:54:14","modified_gmt":"2021-03-16T22:54:14","slug":"meta-analysis-of-diagnostic-performance-of-serological-tests-for-sars-cov-2-antibodies-and-public-health-implications","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/08\/meta-analysis-of-diagnostic-performance-of-serological-tests-for-sars-cov-2-antibodies-and-public-health-implications\/","title":{"rendered":"Meta-Analysis of Diagnostic Performance of Serological Tests for SARS-CoV-2 Antibodies and Public Health Implications"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A meta-analysis of the diagnostic performance of several serological tests (commercial ELISA or CMIA\/CLIA assays and in-house tests) to assess their real-world performance under scenarios of varying proportion of infected individuals found high specificity (pooled estimates of 98% for IgM and 99% for both IgG and total antibodies) but<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">an unsatisfactory pooled sensitivity of 82-85%.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Even with high specificity, the data suggest that serological tests for large-scale prevalence surveys may only be justifiable in hard-hit areas where the\u00a0<\/span><span data-contrast=\"auto\">positive predictive value of a positive test\u00a0<\/span><span data-contrast=\"auto\">would be acceptable, and that they should be used with caution elsewhere.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Caini<\/span><\/i><i><span data-contrast=\"none\">\u00a0et al. (May 8, 2020). Meta-Analysis of Diagnostic Performance of Serological Tests for SARS-CoV-2 Antibodies and Public Health Implications. Pre-print downloaded May 8 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.03.20084160\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.03.20084160<\/span><\/a><i><span data-contrast=\"none\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A meta-analysis of the diagnostic performance of several serological tests (commercial ELISA or CMIA\/CLIA assays and in-house tests) to assess their real-world performance under scenarios of varying proportion of infected individuals found high specificity (pooled estimates of 98% for IgM and 99% for both IgG and total antibodies) but\u00a0an unsatisfactory pooled sensitivity of 82-85%.\u00a0 Even&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/08\/meta-analysis-of-diagnostic-performance-of-serological-tests-for-sars-cov-2-antibodies-and-public-health-implications\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-6711","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6711"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6711\/revisions"}],"predecessor-version":[{"id":6712,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6711\/revisions\/6712"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6711"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}