{"id":6713,"date":"2020-05-08T15:54:28","date_gmt":"2020-05-08T22:54:28","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6713"},"modified":"2021-03-16T15:55:17","modified_gmt":"2021-03-16T22:55:17","slug":"observational-study-of-hydroxychloroquine-in-hospitalized-patients-with-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/08\/observational-study-of-hydroxychloroquine-in-hospitalized-patients-with-covid-19\/","title":{"rendered":"Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Geleris<\/span><span data-contrast=\"auto\">\u00a0et al.\u00a0<\/span><span data-contrast=\"auto\">conducted an<\/span><span data-contrast=\"auto\">\u00a0observational study\u00a0<\/span><span data-contrast=\"auto\">of the<\/span><span data-contrast=\"auto\">\u00a0association between hydroxychloroquine use and intubation or death<\/span><span data-contrast=\"auto\">\u00a0among\u00a0<\/span><span data-contrast=\"auto\">1,446 consecutive patients at a large medical center in New York City. During a median follow-up of 22.5 days, 5<\/span><span data-contrast=\"auto\">9<\/span><span data-contrast=\"auto\">% received hydroxychloroquine either within 24 or 48 hours after presentation to the emergen<\/span><span data-contrast=\"auto\">cy department, and 25<\/span><span data-contrast=\"auto\">% experienced a primary\u00a0<\/span><span data-contrast=\"auto\">endpoint\u00a0<\/span><span data-contrast=\"auto\">(either intubation or death). Those\u00a0<\/span><span data-contrast=\"auto\">who\u00a0<\/span><span data-contrast=\"auto\">were treated with hydroxychloroquine were more severely ill at baseline than those were not.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">There was<\/span><span data-contrast=\"auto\">\u00a0no association between hydroxychloroquine use and intubation or death (HR 1.04, 95% CI 0.82-1.32). While the results do not support either benefit or harm from hydroxychloroquine, the authors\u00a0<\/span><span data-contrast=\"auto\">recognize\u00a0<\/span><span data-contrast=\"auto\">the limitations of the observational design and\u00a0<\/span><span data-contrast=\"auto\">emphasize the\u00a0<\/span><span data-contrast=\"auto\">need for\u00a0<\/span><span data-contrast=\"auto\">randomized trial evidence<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Geleris<\/span><\/i><i><span data-contrast=\"none\">\u00a0et al. (May 7, 2020). Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19. The New England Journal of Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2012410\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1056\/NEJMoa2012410<\/span><\/a><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Geleris\u00a0et al.\u00a0conducted an\u00a0observational study\u00a0of the\u00a0association between hydroxychloroquine use and intubation or death\u00a0among\u00a01,446 consecutive patients at a large medical center in New York City. During a median follow-up of 22.5 days, 59% received hydroxychloroquine either within 24 or 48 hours after presentation to the emergency department, and 25% experienced a primary\u00a0endpoint\u00a0(either intubation or death). Those\u00a0who\u00a0were treated&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/08\/observational-study-of-hydroxychloroquine-in-hospitalized-patients-with-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-6713","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6713"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6713\/revisions"}],"predecessor-version":[{"id":6714,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6713\/revisions\/6714"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6713"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6713"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6713"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}