{"id":6717,"date":"2020-05-08T15:56:23","date_gmt":"2020-05-08T22:56:23","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6717"},"modified":"2021-03-16T15:57:11","modified_gmt":"2021-03-16T22:57:11","slug":"detection-of-low-levels-of-sars-cov-2-rna-from-nasopharyngeal-swabs-using-three-commercial-molecular-assays","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/08\/detection-of-low-levels-of-sars-cov-2-rna-from-nasopharyngeal-swabs-using-three-commercial-molecular-assays\/","title":{"rendered":"Detection of Low Levels of SARS-CoV-2 RNA from Nasopharyngeal Swabs Using Three Commercial Molecular Assays"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Lowe et al. compared the testing results of SARS-CoV-2 between<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">three commercial assays<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">for SARS-CoV-2\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">Xpert<\/span><span data-contrast=\"auto\">\u00a0Xpress<\/span><span data-contrast=\"auto\">\u00a0SARS-CoV-2<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">cobas<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0and\u00a0<\/span><span data-contrast=\"auto\">Lightmix<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Modular SARS<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0using 37 nasopharyngeal (NP) swabs with low<\/span><span data-contrast=\"auto\">er<\/span><span data-contrast=\"auto\">\u00a0levels of SARS-CoV-2 RNA (30 with Ct value between 30-33.9, 22 with Ct \u226534, and 5 negative for SARS-CoV-2).\u00a0<\/span><span data-contrast=\"auto\">The o<\/span><span data-contrast=\"auto\">verall concordance was 86.5% (32\/37), including a 100% concordance for samples with\u00a0<\/span><span data-contrast=\"auto\">moderate\u00a0<\/span><span data-contrast=\"auto\">viral concentrations (<\/span><span data-contrast=\"auto\">Ct\u00a0<\/span><span data-contrast=\"auto\">between\u00a0<\/span><span data-contrast=\"auto\">30<\/span><span data-contrast=\"auto\">\u00a0to\u00a0<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">33.9<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">, but a discordance of 22.7% (5\/22) amongst samples with\u00a0<\/span><span data-contrast=\"auto\">lower viral concentrations (<\/span><span data-contrast=\"auto\">Ct \u226534<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">Testing of SARS-CoV-2 on the three commercial assays was comparable for NP swabs with moderate Ct values, while high Ct values were less concordant<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Lowe et al. (Apr 28, 2020). Detection of Low Levels of SARS-CoV-2 RNA from Nasopharyngeal Swabs Using Three Commercial Molecular Assays. Journal of Clinical Virology.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.jcv.2020.104387\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.jcv.2020.104387<\/span><\/a><i><span data-contrast=\"none\">\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lowe et al. compared the testing results of SARS-CoV-2 between\u00a0three commercial assays\u00a0for SARS-CoV-2\u00a0(Xpert\u00a0Xpress\u00a0SARS-CoV-2,\u00a0cobas,\u00a0and\u00a0Lightmix\u00a0Modular SARS)\u00a0using 37 nasopharyngeal (NP) swabs with lower\u00a0levels of SARS-CoV-2 RNA (30 with Ct value between 30-33.9, 22 with Ct \u226534, and 5 negative for SARS-CoV-2).\u00a0The overall concordance was 86.5% (32\/37), including a 100% concordance for samples with\u00a0moderate\u00a0viral concentrations (Ct\u00a0between\u00a030\u00a0to\u00a0&#8211;33.9), but a discordance&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/08\/detection-of-low-levels-of-sars-cov-2-rna-from-nasopharyngeal-swabs-using-three-commercial-molecular-assays\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-6717","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6717","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6717"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6717\/revisions"}],"predecessor-version":[{"id":6718,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6717\/revisions\/6718"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6717"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6717"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6717"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6717"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}