{"id":6719,"date":"2020-05-08T15:57:18","date_gmt":"2020-05-08T22:57:18","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6719"},"modified":"2021-03-16T15:58:06","modified_gmt":"2021-03-16T22:58:06","slug":"t-cell-subset-counts-in-peripheral-blood-can-be-used-as-discriminatory-biomarkers-for-diagnosis-and-severity-prediction-of-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/08\/t-cell-subset-counts-in-peripheral-blood-can-be-used-as-discriminatory-biomarkers-for-diagnosis-and-severity-prediction-of-covid-19\/","title":{"rendered":"T Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of COVID-19"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Among<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">patients\u00a0<\/span><span data-contrast=\"auto\">hospitalized for<\/span><span data-contrast=\"auto\">\u00a0COVID-19<\/span><span data-contrast=\"auto\">\u00a0(n=103),\u00a0<\/span><span data-contrast=\"auto\">compared<\/span><span data-contrast=\"auto\">\u00a0to<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">healthy controls (n=13),\u00a0<\/span><span data-contrast=\"auto\">there were<\/span><span data-contrast=\"auto\">\u00a0slight\u00a0<\/span><span data-contrast=\"auto\">lower\u00a0<\/span><span data-contrast=\"auto\">CD4+T cells<\/span><span data-contrast=\"auto\">\u00a0counts<\/span><span data-contrast=\"auto\">\u00a0but a severe\u00a0<\/span><span data-contrast=\"auto\">lower<\/span><span data-contrast=\"auto\">\u00a0CD8+T cell<\/span><span data-contrast=\"auto\">\u00a0counts\u00a0<\/span><span data-contrast=\"auto\">in COVID-19 patients.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">COVID-19 patients\u00a0<\/span><span data-contrast=\"auto\">with severe disease\u00a0<\/span><span data-contrast=\"auto\">showed significant decreases in T cell subset counts compared to mild-to-moderate patients. This suggests that T cell subset counts, particularly e<\/span><span data-contrast=\"auto\">levated CD4\/CD8 ratios could\u00a0<\/span><span data-contrast=\"auto\">potentially\u00a0<\/span><span data-contrast=\"auto\">be\u00a0<\/span><span data-contrast=\"auto\">used as discriminatory biomarkers for diagnosis and severity prediction.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Jiang et al. (May 7, 2020). T Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Sever<\/span><\/i><i><span data-contrast=\"none\">ity Prediction of COVID-19.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Journal of Infectious Diseases.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/infdis\/jiaa252\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1093\/infdis\/jiaa252<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Among\u00a0patients\u00a0hospitalized for\u00a0COVID-19\u00a0(n=103),\u00a0compared\u00a0to\u00a0healthy controls (n=13),\u00a0there were\u00a0slight\u00a0lower\u00a0CD4+T cells\u00a0counts\u00a0but a severe\u00a0lower\u00a0CD8+T cell\u00a0counts\u00a0in COVID-19 patients.\u00a0COVID-19 patients\u00a0with severe disease\u00a0showed significant decreases in T cell subset counts compared to mild-to-moderate patients. This suggests that T cell subset counts, particularly elevated CD4\/CD8 ratios could\u00a0potentially\u00a0be\u00a0used as discriminatory biomarkers for diagnosis and severity prediction.\u00a0 Jiang et al. (May 7, 2020). T Cell Subset Counts&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/08\/t-cell-subset-counts-in-peripheral-blood-can-be-used-as-discriminatory-biomarkers-for-diagnosis-and-severity-prediction-of-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-6719","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6719","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6719"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6719\/revisions"}],"predecessor-version":[{"id":6720,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6719\/revisions\/6720"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6719"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6719"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6719"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}