{"id":6740,"date":"2021-03-16T15:59:15","date_gmt":"2021-03-16T22:59:15","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6740"},"modified":"2021-03-17T16:00:16","modified_gmt":"2021-03-17T23:00:16","slug":"bnt162b2-mrna-covid-19-vaccine-induces-antibodies-of-broader-cross-reactivity-than-natural-infection-but-recognition-of-mutant-viruses-is-up-to-10-fold-reduced","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/16\/bnt162b2-mrna-covid-19-vaccine-induces-antibodies-of-broader-cross-reactivity-than-natural-infection-but-recognition-of-mutant-viruses-is-up-to-10-fold-reduced\/","title":{"rendered":"BNT162b2 MRNA COVID-19 Vaccine Induces Antibodies of Broader Cross-Reactivity than Natural Infection but Recognition of Mutant Viruses Is up to 10-Fold Reduced"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> Antibodies induced by the Pfizer-BioNTech vaccine had higher binding capacities (avidity) than antibodies induced by natural infection against the receptor binding domain (RBD) containing mutations representative of circulating SARS-CoV-2 variants of concern (N501Y, K417N, E484K, and a combination of all three).\u00a0 Vaccine-induced sera (n=6) reduced binding against the RBD containing the N501Y and K417 mutations (2.5-3 fold reduction) compared to wild type RBD. Of note, both the RBD with E484K mutation and RBD with all three mutations reduced binding by ~10-fold, indicating that E484K mutation (found in the B.1.351 and P.1 variant but not in the B.1.1.7 variant) substantially reduces antibody binding.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Chang et al.\u00a0(Mar 15, 2021). BNT162b2 MRNA COVID-19 Vaccine Induces Antibodies of Broader Cross-Reactivity than Natural Infection but Recognition of Mutant Viruses Is up to 10-Fold Reduced. Pre-print downloaded Mar 16 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.03.13.435222\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.03.13.435222<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Antibodies induced by the Pfizer-BioNTech vaccine had higher binding capacities (avidity) than antibodies induced by natural infection against the receptor binding domain (RBD) containing mutations representative of circulating SARS-CoV-2 variants of concern (N501Y, K417N, E484K, and a combination of all three).\u00a0 Vaccine-induced sera (n=6) reduced binding against the RBD containing the N501Y&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/16\/bnt162b2-mrna-covid-19-vaccine-induces-antibodies-of-broader-cross-reactivity-than-natural-infection-but-recognition-of-mutant-viruses-is-up-to-10-fold-reduced\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[142],"topic":[31],"class_list":["post-6740","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccine","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6740","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6740"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6740\/revisions"}],"predecessor-version":[{"id":6741,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6740\/revisions\/6741"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6740"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6740"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6740"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6740"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}