{"id":6780,"date":"2020-05-12T16:45:26","date_gmt":"2020-05-12T23:45:26","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6780"},"modified":"2021-03-17T16:46:19","modified_gmt":"2021-03-17T23:46:19","slug":"association-of-treatment-with-hydroxychloroquine-or-azithromycin-with-in-hospital-mortality-in-patients-with-covid-19-in-new-york-state","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/12\/association-of-treatment-with-hydroxychloroquine-or-azithromycin-with-in-hospital-mortality-in-patients-with-covid-19-in-new-york-state\/","title":{"rendered":"Association of Treatment\u00a0With\u00a0Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"40\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">A retrospective multi-center cohort study<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">sampled randomly from all admitted participants with laboratory-confirmed COVID-19 in 25 hospitals<\/span><span data-contrast=\"auto\">\u00a0(N=1,438)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">and\u00a0<\/span><span data-contrast=\"auto\">compare<\/span><span data-contrast=\"auto\">d<\/span><span data-contrast=\"auto\">\u00a0hydroxychloroquine<\/span><span data-contrast=\"auto\">\u00a0alone, azithromycin\u00a0<\/span><span data-contrast=\"auto\">alone<\/span><span data-contrast=\"auto\">, and<\/span><span data-contrast=\"auto\">\u00a0combination of the two<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">relative\u00a0<\/span><span data-contrast=\"auto\">to treatment with neither medication<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"auto\">There was\u00a0<\/span><span data-contrast=\"auto\">a\u00a0<\/span><span data-contrast=\"auto\">greater odds of cardiac arrest in patients receiving<\/span><span data-contrast=\"auto\">\u00a0combination therapy (OR 2.13 95% CI: 1.12, 4.05), but otherwise\u00a0<\/span><span data-contrast=\"auto\">no\u00a0<\/span><span data-contrast=\"auto\">statistically significant associates with<\/span><span data-contrast=\"auto\">\u00a0mortality<\/span><span data-contrast=\"auto\">\u00a0or abnormal electrocardiogram findings<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"40\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">However, combination therapy had a non-significant<\/span><span data-contrast=\"auto\">\u00a0association<\/span><span data-contrast=\"auto\">\u00a0with increased risk of\u00a0<\/span><span data-contrast=\"auto\">mortality\u00a0<\/span><span data-contrast=\"auto\">(HR 1.35, 95% CI 0.76, 2.40)<\/span><span data-contrast=\"auto\">\u00a0and abnormal ECG findings (<\/span><span data-contrast=\"auto\">OR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">1.55, 95%CI 0.89<\/span><span data-contrast=\"auto\">\u2013<\/span><span data-contrast=\"auto\">2.67)<\/span><span data-contrast=\"auto\">, as did hydroxychloroquine alone for cardiac arrest<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">OR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">1.91, 95%CI: 0.96<\/span><span data-contrast=\"auto\">\u2013<\/span><span data-contrast=\"auto\">3.81)<\/span><span data-contrast=\"auto\">\u00a0and abnormal ECG findings (<\/span><span data-contrast=\"auto\">OR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">1.50, 95%CI: 0.88<\/span><span data-contrast=\"auto\">\u2013<\/span><span data-contrast=\"auto\">2.58)<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">The effect of\u00a0<\/span><span data-contrast=\"auto\">h<\/span><span data-contrast=\"auto\">ydroxychloroquine alone\u00a0<\/span><span data-contrast=\"auto\">was also\u00a0<\/span><span data-contrast=\"auto\">non-significantly associate with a small increased risk of<\/span><span data-contrast=\"auto\">\u00a0mortality (<\/span><span data-contrast=\"auto\">HR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">1.08, 95%CI 0.63<\/span><span data-contrast=\"auto\">\u2013<\/span><span data-contrast=\"auto\">1.85).\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"40\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Azithromycin alone\u00a0<\/span><span data-contrast=\"auto\">was associated with a\u00a0<\/span><span data-contrast=\"auto\">non-significant\u00a0<\/span><span data-contrast=\"auto\">lower risk of mortality\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">HR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">0.56, 95%C<\/span><span data-contrast=\"auto\">I<\/span><span data-contrast=\"auto\">\u00a00.26<\/span><span data-contrast=\"auto\">\u2013<\/span><span data-contrast=\"auto\">1.21<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0cardiac arrest (<\/span><span data-contrast=\"auto\">OR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">0.64, 95%CI: 0.27<\/span><span data-contrast=\"auto\">\u2013<\/span><span data-contrast=\"auto\">1.56)<\/span><span data-contrast=\"auto\">, and abnormal ECG findings (<\/span><span data-contrast=\"auto\">OR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">0.95, 95%CI 0.77<\/span><span data-contrast=\"auto\">\u2013<\/span><span data-contrast=\"auto\">3.24)<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"40\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">While\u00a0<\/span><span data-contrast=\"auto\">limited by the observational design<\/span><span data-contrast=\"auto\">, t<\/span><span data-contrast=\"auto\">hese findings provide\u00a0<\/span><span data-contrast=\"auto\">concerning\u00a0<\/span><span data-contrast=\"auto\">evidence that treatment with hydroxychloroquine is associated with a higher likelihood of mortality and adverse cardiac outcome<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">, and that addition of azithromycin may\u00a0<\/span><span data-contrast=\"auto\">increase th<\/span><span data-contrast=\"auto\">ese risks\u00a0<\/span><span data-contrast=\"auto\">further.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Rosenberg et al. (May 11, 2020). Association of Treatment\u00a0<\/span><\/i><i><span data-contrast=\"none\">With<\/span><\/i><i><span data-contrast=\"none\">\u00a0Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State. JAMA.<\/span><\/i><i><span data-contrast=\"auto\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jama.2020.8630\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1001\/jama.2020.8630<\/span><\/i><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A retrospective multi-center cohort study\u00a0sampled randomly from all admitted participants with laboratory-confirmed COVID-19 in 25 hospitals\u00a0(N=1,438)\u00a0and\u00a0compared\u00a0hydroxychloroquine\u00a0alone, azithromycin\u00a0alone, and\u00a0combination of the two\u00a0relative\u00a0to treatment with neither medication.\u00a0\u00a0 There was\u00a0a\u00a0greater odds of cardiac arrest in patients receiving\u00a0combination therapy (OR 2.13 95% CI: 1.12, 4.05), but otherwise\u00a0no\u00a0statistically significant associates with\u00a0mortality\u00a0or abnormal electrocardiogram findings.\u00a0\u00a0 However, combination therapy had a non-significant\u00a0association\u00a0with&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/12\/association-of-treatment-with-hydroxychloroquine-or-azithromycin-with-in-hospital-mortality-in-patients-with-covid-19-in-new-york-state\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-6780","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6780"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6780\/revisions"}],"predecessor-version":[{"id":6781,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6780\/revisions\/6781"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6780"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}