{"id":6803,"date":"2020-05-13T16:57:08","date_gmt":"2020-05-13T23:57:08","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6803"},"modified":"2021-03-17T17:13:52","modified_gmt":"2021-03-18T00:13:52","slug":"covid-19-literature-situation-report-may-13-2020","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/13\/covid-19-literature-situation-report-may-13-2020\/","title":{"rendered":"COVID-19 Literature Situation Report May 13, 2020"},"content":{"rendered":"<p>The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.<\/p>\n<h2>Key Takeaways<\/h2>\n<ul>\n<li><b><span data-contrast=\"auto\">Salazar et al.\u00a0<\/span><\/b><b><span data-contrast=\"auto\">repor<\/span><\/b><b><span data-contrast=\"auto\">t<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><b><span data-contrast=\"auto\">safety and\u00a0<\/span><\/b><b><span data-contrast=\"auto\">improve<\/span><\/b><b><span data-contrast=\"auto\">d\u00a0<\/span><\/b><b><span data-contrast=\"auto\">clinical\u00a0<\/span><\/b><b><span data-contrast=\"auto\">status<\/span><\/b><b><span data-contrast=\"auto\">\u00a0among 25 patients with severe COVID-19\u00a0<\/span><\/b><b><span data-contrast=\"auto\">after transfusing\u00a0<\/span><\/b><b><span data-contrast=\"auto\">convalescent\u00a0<\/span><\/b><b><span data-contrast=\"auto\">plasma\u00a0<\/span><\/b><b><span data-contrast=\"auto\">from donors with confirmed SARS-CoV-2 infection<\/span><\/b><b><span data-contrast=\"auto\">.<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">L<\/span><\/b><b><span data-contrast=\"auto\">ow<\/span><\/b><b><span data-contrast=\"auto\">\u00a0rates of SARS-CoV-2 infection\u00a0<\/span><\/b><b><span data-contrast=\"auto\">were reported among<\/span><\/b><b><span data-contrast=\"auto\">\u00a0asymptomatic patients screened prior to admission or a\u00a0<\/span><\/b><b><span data-contrast=\"auto\">planned<\/span><\/b><b><span data-contrast=\"auto\">\u00a0procedure\u00a0<\/span><\/b><b><span data-contrast=\"auto\">at<\/span><\/b><b><span data-contrast=\"auto\">\u00a0the University of Washington Medical Center.\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">A s<\/span><\/b><b><span data-contrast=\"auto\">ystematic review<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><b><span data-contrast=\"auto\">and meta-analysis\u00a0estimates<\/span><\/b><b><span data-contrast=\"auto\">\u00a015% of patients with COVID-19 had gastrointestinal symptoms and nearly one in five<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><b><span data-contrast=\"auto\">had abnormal<\/span><\/b><b><span data-contrast=\"auto\">\u00a0lab<\/span><\/b><b><span data-contrast=\"auto\">\u00a0values indicating liver injury.\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Robust, physician-directed telehealth services can meet a wide range of needs during the acute phase of a pandemic<\/span><\/b><b><span data-contrast=\"auto\">, which can conserve<\/span><\/b><b><span data-contrast=\"auto\">\u00a0scarce resources<\/span><\/b><b><span data-contrast=\"auto\">\u00a0and prevent<\/span><\/b><b><span data-contrast=\"auto\">\u00a0the spread of infections to patients and health care workers.<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"4\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Vitamin D deficiency\u00a0<\/span><\/b><b><span data-contrast=\"auto\">may be\u00a0<\/span><\/b><b><span data-contrast=\"auto\">associated with COVID-19 risk. Testing and treatment for vitamin D deficiency to\u00a0<\/span><\/b><b><span data-contrast=\"auto\">reduce\u00a0risk\u00a0of<\/span><\/b><b><span data-contrast=\"auto\">\u00a0COVID-19\u00a0<\/span><\/b><b><span data-contrast=\"auto\">may\u00a0<\/span><\/b><b><span data-contrast=\"auto\">warrant\u00a0<\/span><\/b><b><span data-contrast=\"auto\">further consideration<\/span><\/b><b><span data-contrast=\"auto\">.<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<div id=\"uw-accordion-shortcode\">\n<h3>Article Summaries<\/h3>\n<div class=\"js-accordion\" data-accordion-prefix-classes=\"uw-accordion-shortcode\">\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Non-Pharmaceutical Interventions<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-6804\" class=\"su-post\">\n<h5 class=\"su-post-title\">Real-Time Tracking of Self-Reported Symptoms to Predict Potential COVID-19<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"49\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Menni et al. examine\u00a0<\/span><span data-contrast=\"auto\">implementation of a smartphone-based app for tracking COVID-19.\u00a0<\/span><span data-contrast=\"auto\">2<\/span><span data-contrast=\"auto\">.6 million<\/span><span data-contrast=\"auto\">\u00a0participants used the app to report their potential sy<\/span><span data-contrast=\"auto\">mptoms. Among\u00a0<\/span><span data-contrast=\"auto\">18,401 who had undergone a SARS-CoV-2 test, the proportion who reported loss of smell and taste was higher in those with a positive result (4,668 of 7,178; 65%) than in those with a negative result (2,436 of 11,223; 2<\/span><span data-contrast=\"auto\">2<\/span><span data-contrast=\"auto\">%). A model combining symptoms to predict probable infection predicted that 140,312 (17%) participants are likely to have COVID-19.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Menni et al. (May 11, 2020). Real-Time Tracking of Self-Reported Symptoms to Predict Potential COVID-19. Nature Medicine<\/span><\/i><i><span data-contrast=\"none\">.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41591-020-0916-2\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1038\/s41591-020-0916-2<\/span><\/i><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Testing and Treatment<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-6812\" class=\"su-post\">\n<h5 class=\"su-post-title\">Treatment of COVID-19 Patients with Convalescent Plasma in Houston Texas<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"45\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Salazar et al. explored the safety of convalescent plasma therapy among 25 patients with severe and\/or life-threatening COVID-19 disease enrolled at the Houston Methodist hospitals. Patients were transfused with convalescent plasma obtained from donors with confirmed SARS-CoV-2 infection\u00a0<\/span><span data-contrast=\"auto\">who\u00a0<\/span><span data-contrast=\"auto\">been symptom free for 14 days.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"45\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">At\u00a0<\/span><span data-contrast=\"auto\">7\u00a0<\/span><span data-contrast=\"auto\">days\u00a0<\/span><span data-contrast=\"auto\">post-transfusion,\u00a0<\/span><span data-contrast=\"auto\">9<\/span><span data-contrast=\"auto\">\u00a0patients had at least a 1-point improvement in clinical scale, and\u00a0<\/span><span data-contrast=\"auto\">7<\/span><span data-contrast=\"auto\">\u00a0of those were discharged. By 14<\/span><span data-contrast=\"auto\">\u00a0days<\/span><span data-contrast=\"auto\">, 19 (76%) patients had at least a 1-point improvement in clinical status and 11 were discharged. No adverse events\u00a0<\/span><span data-contrast=\"auto\">due to\u00a0<\/span><span data-contrast=\"auto\">plasma transfusion were observed.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Salazar et al. (May 13, 2020). Treatment of COVID-19 Patients with Convalescent Plasma in Houston Texas. Pre-print\u00a0downloaded May 13 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.08.20095471\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.08.20095471<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-6810\" class=\"su-post\">\n<h5 class=\"su-post-title\">Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"46\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">A retrospective cohort study found some evidence that a vitamin D deficiency in the past year was associated with\u00a0<\/span><span data-contrast=\"auto\">an increased risk of testing positive for SARS-CoV-2.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Meltzer et al. (May 13, 2020). Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence. Pre-print\u00a0downloaded May 13 from<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.08.20095893\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.08.20095893<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-6808\" class=\"su-post\">\n<h5 class=\"su-post-title\">Prolonged Viral RNA Shedding after COVID-19 Symptom Resolution in Older Convalescent Plasma Donors<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"47\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Re-testing of 86 previously SARS-CoV-2 positive patients from a Wisconsin\u00a0<\/span><span data-contrast=\"auto\">tertiary<\/span><span data-contrast=\"auto\">\u00a0care center after self-reported symptom resolution showed that 11 (13%) were still positive at a median of 19 days (range 12-24 days) after symptom resolution. Patients who re-tested positive were not significantly different from test-negative patients with respect to days since symptom recovery.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"47\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">To the extent that detection of SARS-CoV-2 RNA following the resolution of symptoms is indicative of potential infectiousness, screening for COVID-19 convalescent plasma donors may need to occur later than the currently recommended two weeks following &#8220;recovery.&#8221;<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Hess and Hartman. (May 12,\u00a02020).\u00a0Prolonged Viral RNA Shedding after COVID-19 Symptom Resolution in Older Convalescent Plasma Donors. Pre-print\u00a0downloaded May 13 from<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.07.20090621\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.07.20090621<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-6806\" class=\"su-post\">\n<h5 class=\"su-post-title\">Pre-Procedural Surveillance Testing for SARS-CoV-2 in an Asymptomatic Population Shows Low Rates of Positivity<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"48\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Among University of Washington Medical Center asymptomatic patients screened prior to admission and patients screened prior to surgical or aerosolizing procedures, a very low proportion tested positive for SARS-CoV-2.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"48\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Among 349 asymptomatic patients tested at admission, 0.9% (n=3) were positive and 0.6% (n=2) were inconclusive. Among 350 patients undergoing surgical or aerosolizing procedures, 0.9% (n=3) were positive. Among 157 asymptomatic patients tested for any other reason, 7.6% (n=12) were positive and 0.6% (n=1) was inconclusive.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"48\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">By comparison, among 473 inpatients with any symptom of COVID-19, 14.3% (n=68) were positive during a time period when the outpatient prevalence of SARS-CoV-2 active infection was 3-5%.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Mays et al. (May 12, 2020). Pre-Procedural Surveillance Testing for SARS-CoV-2 in an Asymptomatic Population Shows Low Rates of Positivity. Pre-print\u00a0downloaded May 13 from<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.08.20078592\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.08.20078592<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Clinical Characteristics and Health Care Setting<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-6816\" class=\"su-post\">\n<h5 class=\"su-post-title\">Manifestations and Prognosis of Gastrointestinal and Liver Involvement in Patients with COVID-19:\u00a0A Systematic\u00a0Review and Meta-Analysis<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Mao et al. conducted a meta-analysis\u00a0<\/span><span data-contrast=\"auto\">of<\/span><span data-contrast=\"auto\">\u00a035 studies, including 6<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">686 patients with COVID-19, to estimate the effects of COVID-19 on the digestive system.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">The pooled prevalence of digestive symptoms (29 studies, n=6064) was 15% (IQR 10\u201321) with nausea or vomiting, diarrhea, and loss of appetite being the three most common symptoms.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">The pooled prevalence of abnormal liver functions (12 studies, n=1267) was 19% (<\/span><span data-contrast=\"auto\">IQR\u00a0<\/span><span data-contrast=\"auto\">9\u201332). Subgroup analysis showed patients with severe COVID-19 had higher rates of gastrointestinal symptoms (<\/span><span data-contrast=\"auto\">OR=<\/span><span data-contrast=\"auto\">1.60, 95%CI 1.09\u20132.36) and liver injury (<\/span><span data-contrast=\"auto\">OR=<\/span><span data-contrast=\"auto\">2.20,\u00a0<\/span><span data-contrast=\"auto\">95%CI\u00a0<\/span><span data-contrast=\"auto\">1.60\u20133.02) compared with those with non-severe disease. Patients with gastrointestinal involvement had a higher prevalence of complication (<\/span><span data-contrast=\"auto\">OR=<\/span><span data-contrast=\"auto\">2.51,\u00a0<\/span><span data-contrast=\"auto\">95%CI\u00a0<\/span><span data-contrast=\"auto\">1.62\u20133.89).<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Mao et al. (May 12, 2020). Manifestations and Prognosis of Gastrointestinal and Liver Involvement in Patients with COVID-19:\u00a0A Systematic\u00a0Review and Meta-Analysis. The Lancet Gastroenterology &amp; Hepatology.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S2468-1253(20)30126-6\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/S2468-1253(20)30126-6<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-6814\" class=\"su-post\">\n<h5 class=\"su-post-title\">COVID\u201019 and the Cerebro\u2010Cardiovascular Systems: What Do We Know\u00a0so\u00a0Far?<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"44\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">SARS\u2010CoV\u20102\u00a0<\/span><span data-contrast=\"auto\">has\u00a0<\/span><span data-contrast=\"auto\">high\u2010affinity for<\/span><span data-contrast=\"auto\">\u00a0the<\/span><span data-contrast=\"auto\">\u00a0angiotensin converting enzyme 2 (ACE2) receptor, which is highly concentrated in the lungs and cardiovascular tissue,\u00a0<\/span><span data-contrast=\"auto\">showing a potential mechanism for\u00a0<\/span><span data-contrast=\"auto\">cardiovascular involvement in COVID\u201019 cases.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"44\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">This literature review of COVID\u201019 and cardiovascular system involvement found evidence of pre\u2010existing cardiovascular and cerebrovascular disease\u00a0<\/span><span data-contrast=\"auto\">is\u00a0<\/span><span data-contrast=\"auto\">a risk\u2010factor for severe infection. COVID\u201019 patients may be more likely to experience acute cardiac injury, arrhythmia, coagulation defects<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0and acute stroke and are likely to have poorer outcomes as a result.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Larson et al. (May 12, 2020). COVID\u201019 and the Cerebro\u2010Cardiovascular Systems: What Do We Know\u00a0so\u00a0Far? Journal of the American Heart Association.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1161\/JAHA.120.016793\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1161\/JAHA.120.016793<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW77639591 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW77639591 BCX0\" data-ccp-parastyle=\"heading 2\">Mental Health and Personal Impact<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-6818\" class=\"su-post\">\n<h5 class=\"su-post-title\">The Early\u00a0Food Insecurity Impacts of COVID-19<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"42\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Niles et al. conducted a statewide population-level survey to assess food insecurity in Vermont from March 29-April 12, 2020, during the beginning of a statewide stay-at-home order.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"42\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Among 3,219 respondents, there was a 33% increase in household food insecurity since COVID-19, with 35.6% of food insecure households classified as newly food insecure. Respondents experiencing a job loss were more likely to experience food insecurity (<\/span><span data-contrast=\"auto\">OR=<\/span><span data-contrast=\"auto\">3.43; 95%CI 2.45-4.80). Coping strategies were significantly different between respondents in newly food insecure vs. consistently insecure households.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Niles et al. (May 13, 2020).\u00a0The Early\u00a0Food Insecurity Impacts of COVID-19. Pre-print\u00a0downloaded May 13 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.09.20096412\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.09.20096412<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Modelling and Prediction<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-6822\" class=\"su-post\">\n<h5 class=\"su-post-title\">The Real Time Effective Reproductive Number for COVID-19 in the United States<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"41\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Keegan et al.\u00a0<\/span><span data-contrast=\"auto\">compared\u00a0<\/span><span data-contrast=\"auto\">the<\/span><span data-contrast=\"auto\">\u00a0reproductive number\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">Rt<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">calculated between\u00a0<\/span><span data-contrast=\"auto\">two methods, the Wallinga and Teunis (WT) method\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">forward-looking<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0and the Cori method<\/span><span data-contrast=\"auto\">\u00a0(<\/span><span data-contrast=\"auto\">backward-looking<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0to estimate the impact of all combined non-pharmaceutical interventions\u00a0<\/span><span data-contrast=\"auto\">in US.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"41\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Results show that most states have been able to reduce the Rt of SARS-CoV-2. However, few states have demonstrated\u00a0an\u00a0ability to maintain Rt below\u00a0<\/span><span data-contrast=\"auto\">a value of 1<\/span><span data-contrast=\"auto\">. The median difference in timing of Rt&lt;1 between the two methods is 6.5 days,\u00a0<\/span><span data-contrast=\"auto\">highlighting the importance of method selection for Rt estimation<\/span><span data-contrast=\"auto\">\u00a0to inform\u00a0<\/span><span data-contrast=\"auto\">policy decision making<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Keegan et al. (May 13, 2020). The Real Time Effective Reproductive Number for COVID-19 in the United States. Pre-print\u00a0downloaded May 13 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.08.20095703\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.08.20095703<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-6820\" class=\"su-post\">\n<h5 class=\"su-post-title\">Significant Relaxation of SARS-CoV-2-Targeted Non-Pharmaceutical Interventions Will Result in Profound Mortality A New York State Modelling Study<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Hoffman modeled the effect of\u00a0<\/span><span data-contrast=\"auto\">unidentified\u00a0<\/span><span data-contrast=\"auto\">infections, seasonal infectivity, immunity, and non-pharmaceutical interventions on the risk of SARS-CoV-2 in New York State. Simulations revealed dramatic infectivity driven by\u00a0<\/span><span data-contrast=\"auto\">unidentified\u00a0<\/span><span data-contrast=\"auto\">infections with a peak basic reproductive number of 5.7.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">R<\/span><span data-contrast=\"auto\">eduction of social distancing by &gt;50%\u00a0<\/span><span data-contrast=\"auto\">below current levels<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">w<\/span><span data-contrast=\"auto\">ould<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">result in\u00a0<\/span><span data-contrast=\"auto\">increased<\/span><span data-contrast=\"auto\">\u00a0mortality<\/span><span data-contrast=\"auto\">. Endemic infection is likely to occur in the absence of profound sustained immunity.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Hoffman. (May 12,\u00a02020).\u00a0Significant Relaxation of SARS-CoV-2-Targeted Non-Pharmaceutical Interventions Will Result in Profound Mortality A New York State Modelling Study. Pre-print\u00a0downloaded May 13 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.08.20095505\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.08.20095505<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Public Health Policy and Practice<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-6828\" class=\"su-post\">\n<h5 class=\"su-post-title\">On the Front (Phone) Lines Results of a COVID-19 Hotline in Northeast Ohio<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Margolius et al. examine the effectiveness of a physician telehealth visit<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">\u00a0during the first five weeks of a 24\/7 physician-staffed COVID-19 hotline<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">in Northeast Ohio. Of 4,213\u00a0<\/span><span data-contrast=\"auto\">calls<\/span><span data-contrast=\"auto\">\u00a0referred for a physician telehealth visit<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">m<\/span><span data-contrast=\"auto\">ost (79%) were advised to self-isolate at home, 14% were determined to be unlikely to have COVID-19, and 3% were advised to seek emergency care. A total of 287 (7%) patients had a subsequent ED visit, and 44 (1%) were hospitalized with a COVID-19 diagnosis.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"auto\">Robust, physician-directed telehealth services can meet a wide range of needs during the acute phase of a pandemic<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0conserving scarce resources and preventing the spread of infections to patients and health care workers.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Margolius et al. (May 13, 2020). On the Front (Phone) Lines Results of a COVID-19 Hotline in Northeast Ohio. Pre-print\u00a0downloaded May 13 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.08.20095745\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.08.20095745<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-6826\" class=\"su-post\">\n<h5 class=\"su-post-title\">Protecting Health during COVID-19 and beyond: A Global Examination of Paid Sick Leave Design in 193 Countries<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"39\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Heymann et al. assess the availability of paid sick leave in 193 UN member states.\u00a0<\/span><span data-contrast=\"auto\">They found\u00a0<\/span><span data-contrast=\"auto\">27%<\/span><span data-contrast=\"auto\">\u00a0of<\/span><span data-contrast=\"auto\">\u00a0countries do not guarantee paid sick leave from the first d<\/span><span data-contrast=\"auto\">ay of illness, and 58%<\/span><span data-contrast=\"auto\">\u00a0do not have explicit provisions to ensure self-employed and gig economy workers have access to paid sick leave benef<\/span><span data-contrast=\"auto\">its.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"39\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Critical gaps remain between\u00a0jeopardize\u00a0health and economic security. Comprehensive paid sick leave policies that cover all workers are urgently needed to reduce the spread of COVID-19, and\u00a0be ready to respond to threats from new pathogens.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Heymann et al. (May 12, 2020). Protecting Health during COVID-19 and beyond: A Global Examination of Paid Sick Leave Design in 193 Countries. Global Public Health.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1080\/17441692.2020.1764076\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1080\/17441692.2020.1764076<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-6824\" class=\"su-post\">\n<h5 class=\"su-post-title\">Estimating Excess 1-Year Mortality Associated with the COVID-19 Pandemic According to Underlying Conditions and Age: A Population-Based Cohort Study<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"40\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Banerjee et al. estimate the excess 1-year COVID-19 mortality under different scenarios by levels of transmission suppression and relative risk (RR)<\/span><span data-contrast=\"auto\">\u00a0of mortality above the baseline level<\/span><span data-contrast=\"auto\">\u00a0using electronic health records from 3.8 million people in\u00a0UK.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"40\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Based on a population-based cohort study\u00a0<\/span><span data-contrast=\"auto\">20%\u00a0<\/span><span data-contrast=\"auto\">of\u00a0<\/span><span data-contrast=\"auto\">the\u00a0<\/span><span data-contrast=\"auto\">population\u00a0<\/span><span data-contrast=\"auto\">is\u00a0<\/span><span data-contrast=\"auto\">in the high-risk category (aged &gt;70 years or aged\u00a0<\/span><span data-contrast=\"auto\">\u00a3<\/span><span data-contrast=\"auto\">70 years with at least one underlying condition)<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">B<\/span><span data-contrast=\"auto\">aseline\u00a0<\/span><span data-contrast=\"auto\">1-year mortality<\/span><span data-contrast=\"auto\">\u00a0(absence of COVID-19)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">is\u00a0<\/span><span data-contrast=\"auto\">estimated\u00a0<\/span><span data-contrast=\"auto\">at<\/span><span data-contrast=\"auto\">\u00a04.46% (95%CI 4.41\u20134.51)<\/span><span data-contrast=\"auto\">\u00a0in the high-risk category<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"40\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Basic methods are provided to estimate expected increase<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">\u00a0in mortality under different scenarios of increased mortality risk<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Banerjee et al. (May 12, 2020). Estimating Excess 1-Year Mortality Associated with the COVID-19 Pandemic According to Underlying Conditions and Age: A Population-Based Cohort Study. The Lancet<\/span><\/i><i><span data-contrast=\"none\">.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(20)30854-0\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/S0140-6736(20)30854-0<\/span><\/a><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3><strong>Other Resources and Commentaries<\/strong><\/h3>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/wps.20767\"><span data-contrast=\"none\">Preventing suicide in the context of the COVID-19 pandemic<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 World Psychiatry (May 11)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/www.cdc.gov\/mmwr\/volumes\/69\/wr\/mm6919e6.htm?s_cid=mm6919e6_w\"><span data-contrast=\"none\">High SARS-CoV-2 Attack Rate Following Exposure at a Choir Practice \u2014 Skagit County, Washington, March 2020<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 MMWR (May 12)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/medrxiv.org\/cgi\/content\/short\/2020.05.07.20094839\"><span data-contrast=\"none\">Compassionate drug (mis)use during pandemics lessons for COVID-19<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Pre-print (May 12)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/www.nature.com\/articles\/d41586-020-01389-3\"><span data-contrast=\"none\">Coronavirus is spreading under the radar in US homeless shelters<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Nature (May 7)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/www.nature.com\/articles\/d41586-020-01403-8\"><span data-contrast=\"none\">Coronavirus blood-clot mystery intensifies<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Nature (May 8)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/link.springer.com\/10.1007\/s40495-020-00216-7\"><span data-contrast=\"none\">An Update on Current Therapeutic Drugs Treating COVID-19<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013\u00a0Curr<\/span><span data-contrast=\"auto\">\u00a0Pharm Reports (May 11)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/science.sciencemag.org\/content\/368\/6490\/476\"><span data-contrast=\"none\">Against pandemic research exceptionalism<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211; Science (<\/span><span data-contrast=\"auto\">May 1<\/span><span data-contrast=\"auto\">)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/medrxiv.org\/cgi\/content\/short\/2020.05.09.20096354\"><span data-contrast=\"none\">Saliva as a non-invasive sample for the detection of SARS-CoV-2 a systematic review<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Pre-print (May 13)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/jamanetwork.com\/channels\/health-forum\/fullarticle\/2766119\"><span data-contrast=\"none\">Sharp Drop in Routine Vaccinations for US Children Amid COVID-19 Pandemic<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 JAMA Health Forum (May 12)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Salazar et al. report safety and improved clinical status among 25 patients with severe COVID-19 after transfusing convalescent plasma from donors with confirmed SARS-CoV-2 infection.  <\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/13\/estimating-excess-1-year-mortality-associated-with-the-covid-19-pandemic-according-to-underlying-conditions-and-age-a-population-based-cohort-study\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":6830,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[5],"tags":[],"topic":[],"class_list":["post-6803","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19-literature-situation-report"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6803","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6803"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6803\/revisions"}],"predecessor-version":[{"id":6832,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6803\/revisions\/6832"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media\/6830"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6803"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}