{"id":6816,"date":"2020-05-13T17:04:38","date_gmt":"2020-05-14T00:04:38","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6816"},"modified":"2021-03-17T17:05:26","modified_gmt":"2021-03-18T00:05:26","slug":"manifestations-and-prognosis-of-gastrointestinal-and-liver-involvement-in-patients-with-covid-19-a-systematic-review-and-meta-analysis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/13\/manifestations-and-prognosis-of-gastrointestinal-and-liver-involvement-in-patients-with-covid-19-a-systematic-review-and-meta-analysis\/","title":{"rendered":"Manifestations and Prognosis of Gastrointestinal and Liver Involvement in Patients with COVID-19:\u00a0A Systematic\u00a0Review and Meta-Analysis"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Mao et al. conducted a meta-analysis\u00a0<\/span><span data-contrast=\"auto\">of<\/span><span data-contrast=\"auto\">\u00a035 studies, including 6<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">686 patients with COVID-19, to estimate the effects of COVID-19 on the digestive system.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">The pooled prevalence of digestive symptoms (29 studies, n=6064) was 15% (IQR 10\u201321) with nausea or vomiting, diarrhea, and loss of appetite being the three most common symptoms.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">The pooled prevalence of abnormal liver functions (12 studies, n=1267) was 19% (<\/span><span data-contrast=\"auto\">IQR\u00a0<\/span><span data-contrast=\"auto\">9\u201332). Subgroup analysis showed patients with severe COVID-19 had higher rates of gastrointestinal symptoms (<\/span><span data-contrast=\"auto\">OR=<\/span><span data-contrast=\"auto\">1.60, 95%CI 1.09\u20132.36) and liver injury (<\/span><span data-contrast=\"auto\">OR=<\/span><span data-contrast=\"auto\">2.20,\u00a0<\/span><span data-contrast=\"auto\">95%CI\u00a0<\/span><span data-contrast=\"auto\">1.60\u20133.02) compared with those with non-severe disease. Patients with gastrointestinal involvement had a higher prevalence of complication (<\/span><span data-contrast=\"auto\">OR=<\/span><span data-contrast=\"auto\">2.51,\u00a0<\/span><span data-contrast=\"auto\">95%CI\u00a0<\/span><span data-contrast=\"auto\">1.62\u20133.89).<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Mao et al. (May 12, 2020). Manifestations and Prognosis of Gastrointestinal and Liver Involvement in Patients with COVID-19:\u00a0A Systematic\u00a0Review and Meta-Analysis. The Lancet Gastroenterology &amp; Hepatology.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S2468-1253(20)30126-6\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/S2468-1253(20)30126-6<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mao et al. conducted a meta-analysis\u00a0of\u00a035 studies, including 6,686 patients with COVID-19, to estimate the effects of COVID-19 on the digestive system.\u00a0The pooled prevalence of digestive symptoms (29 studies, n=6064) was 15% (IQR 10\u201321) with nausea or vomiting, diarrhea, and loss of appetite being the three most common symptoms.\u00a0\u00a0 The pooled prevalence of abnormal liver&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/13\/manifestations-and-prognosis-of-gastrointestinal-and-liver-involvement-in-patients-with-covid-19-a-systematic-review-and-meta-analysis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-6816","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6816","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6816"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6816\/revisions"}],"predecessor-version":[{"id":6817,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6816\/revisions\/6817"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6816"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6816"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6816"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6816"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}