{"id":6840,"date":"2020-05-14T17:18:56","date_gmt":"2020-05-15T00:18:56","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6840"},"modified":"2021-03-17T17:19:39","modified_gmt":"2021-03-18T00:19:39","slug":"tracing-two-causative-snps-reveals-sars-cov-2-transmission-in-north-america-population","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/14\/tracing-two-causative-snps-reveals-sars-cov-2-transmission-in-north-america-population\/","title":{"rendered":"Tracing Two Causative SNPs Reveals SARS-CoV-2 Transmission in North America Population"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Based on phylogenetic analysis of 2,599 global SARS-CoV-2 viral RNA sequences, the dominant strains circulating in North America are most closely related to those that predominate in Europe.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">A genome wide association study identified two mutations that predominate in North American samples. The authors hypothesize these mutations may be associated with increased transmissibility and\u00a0<\/span><span data-contrast=\"auto\">that\u00a0<\/span><span data-contrast=\"auto\">the mutations may have first emerged in Europe. These mutations result in two missense mutations (i.e.\u00a0a single base pair mutation that causes the substitution of a different amino acid) in the ORF1ab and ORF3a\u00a0proteins, and\u00a0may be targets for novel diagnostic and drug technologies.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Ou et al. (May 14, 2020). Tracing Two Causative SNPs Reveals SARS-CoV-2 Transmission in North America Population. Pre-print\u00a0downloaded May 14 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.12.092056\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.12.092056<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Based on phylogenetic analysis of 2,599 global SARS-CoV-2 viral RNA sequences, the dominant strains circulating in North America are most closely related to those that predominate in Europe.\u00a0\u00a0 A genome wide association study identified two mutations that predominate in North American samples. The authors hypothesize these mutations may be associated with increased transmissibility and\u00a0that\u00a0the mutations&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/14\/tracing-two-causative-snps-reveals-sars-cov-2-transmission-in-north-america-population\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[21],"class_list":["post-6840","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6840"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6840\/revisions"}],"predecessor-version":[{"id":6841,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6840\/revisions\/6841"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6840"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}