{"id":6861,"date":"2020-05-15T17:31:37","date_gmt":"2020-05-16T00:31:37","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6861"},"modified":"2021-03-17T17:32:27","modified_gmt":"2021-03-18T00:32:27","slug":"saliva-is-less-sensitive-than-nasopharyngeal-swabs-for-covid-19-detection-in-the-community-setting","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/15\/saliva-is-less-sensitive-than-nasopharyngeal-swabs-for-covid-19-detection-in-the-community-setting\/","title":{"rendered":"Saliva Is Less Sensitive than Nasopharyngeal Swabs for COVID-19 Detection in\u00a0the Community\u00a0Setting"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Saliva-based testing<\/span><span data-contrast=\"auto\">, compared to nasopharyngeal swabs (NPS),<\/span><span data-contrast=\"auto\">\u00a0was found to be 15%\u00a0<\/span><span data-contrast=\"auto\">less sensitive in a community-based diagnostic setting (N=88)\u00a0<\/span><span data-contrast=\"auto\">and 50%\u00a0<\/span><span data-contrast=\"auto\">less sensitive in\u00a0<\/span><span data-contrast=\"auto\">a\u00a0<\/span><span data-contrast=\"auto\">convalescent<\/span><span data-contrast=\"auto\">\u00a0cohort<\/span><span data-contrast=\"auto\">\u00a0(&gt;8 and &lt;21 days from first symptoms; N=24).\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">In the community-based diagnostic setting<\/span><span data-contrast=\"auto\">, s<\/span><span data-contrast=\"auto\">aliva samples were randomized to<\/span><span data-contrast=\"auto\">\u00a0two<\/span><span data-contrast=\"auto\">\u00a0collection tube type<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">\u00a0(OM-505 and OGD-610) with different proprietary nucleic acid stabilization solutions,\u00a0<\/span><span data-contrast=\"auto\">and<\/span><span data-contrast=\"auto\">\u00a0testing\u00a0<\/span><span data-contrast=\"auto\">was\u00a0<\/span><span data-contrast=\"auto\">completed at\u00a0<\/span><span data-contrast=\"auto\">Helix,\u00a0<\/span><span data-contrast=\"auto\">a high-complexity CLIA laboratory<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">NPS samples were tested using the CDC COVID-19 assay at the Nevada State Public Health Laboratory.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">In the\u00a0<\/span><span data-contrast=\"auto\">convalescent cohort,\u00a0previously-diagnosed\u00a0patients were recalled for paired NPS and saliva collection, using the OG-610 kit; both tests were conducted at Helix.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Becker et al<\/span><\/i><i><span data-contrast=\"none\">. (<\/span><\/i><i><span data-contrast=\"none\">May 15,\u00a0<\/span><\/i><i><span data-contrast=\"none\">2020). Saliva Is Less Sensitive than Nasopharyngeal Swabs for COVID-19 Detection in\u00a0the Community\u00a0Setting.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print\u00a0downloaded May 1<\/span><\/i><i><span data-contrast=\"none\">5<\/span><\/i><i><span data-contrast=\"none\">\u00a0from<\/span><\/i><i><span data-contrast=\"auto\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.11.20092338\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.11.20092338<\/span><\/i><\/a><i><span data-contrast=\"auto\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Saliva-based testing, compared to nasopharyngeal swabs (NPS),\u00a0was found to be 15%\u00a0less sensitive in a community-based diagnostic setting (N=88)\u00a0and 50%\u00a0less sensitive in\u00a0a\u00a0convalescent\u00a0cohort\u00a0(&gt;8 and &lt;21 days from first symptoms; N=24).\u00a0\u00a0 In the community-based diagnostic setting, saliva samples were randomized to\u00a0two\u00a0collection tube types\u00a0(OM-505 and OGD-610) with different proprietary nucleic acid stabilization solutions,\u00a0and\u00a0testing\u00a0was\u00a0completed at\u00a0Helix,\u00a0a high-complexity CLIA laboratory.\u00a0NPS samples were&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/15\/saliva-is-less-sensitive-than-nasopharyngeal-swabs-for-covid-19-detection-in-the-community-setting\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-6861","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6861","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6861"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6861\/revisions"}],"predecessor-version":[{"id":6862,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6861\/revisions\/6862"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6861"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6861"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6861"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6861"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}