{"id":6914,"date":"2020-05-18T12:38:53","date_gmt":"2020-05-18T19:38:53","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6914"},"modified":"2021-03-18T12:39:47","modified_gmt":"2021-03-18T19:39:47","slug":"iga-mab-blocks-sars-cov-2-spike-ace2-interaction-providing-mucosal-immunity","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/18\/iga-mab-blocks-sars-cov-2-spike-ace2-interaction-providing-mucosal-immunity\/","title":{"rendered":"IgA\u00a0MAb\u00a0Blocks SARS-CoV-2 Spike-ACE2 Interaction Providing Mucosal Immunity"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"37\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Ejemel\u00a0<\/span><span data-contrast=\"auto\">et al. identified\u00a0<\/span><span data-contrast=\"auto\">a cross-reactive human IgA monoclonal antibody<\/span><span data-contrast=\"auto\">\u00a0(<\/span><span data-contrast=\"auto\">MAb362<\/span><span data-contrast=\"auto\">) than can\u00a0<\/span><span data-contrast=\"auto\">bind to both SARS-CoV\u00a0and SARS-CoV-2 spike proteins and competitively block hACE2 receptor binding.\u00a0<\/span><span data-contrast=\"auto\">It<\/span><span data-contrast=\"auto\">\u00a0also neutralizes both\u00a0pseudotyped\u00a0SARS-CoV\u00a0and SARS-CoV-2 in human epithelial cells expressing hACE2. MAb362<\/span><span data-contrast=\"auto\">\u00a0IgA\u00a0<\/span><span data-contrast=\"auto\">may provide effective immunity against SARS-CoV-2 by inducing mucosal immunity within the respiratory system, a potentially critical feature of an effective vaccine.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Ejemel\u00a0et al. (May 15, 2020). IgA\u00a0MAb\u00a0Blocks SARS-CoV-2 Spike-ACE2 Interaction Providing Mucosal Immunity. Pre-print\u00a0downloaded May 18 from<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1101\/2020.05.15.096719\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.15.096719<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ejemel\u00a0et al. identified\u00a0a cross-reactive human IgA monoclonal antibody\u00a0(MAb362) than can\u00a0bind to both SARS-CoV\u00a0and SARS-CoV-2 spike proteins and competitively block hACE2 receptor binding.\u00a0It\u00a0also neutralizes both\u00a0pseudotyped\u00a0SARS-CoV\u00a0and SARS-CoV-2 in human epithelial cells expressing hACE2. MAb362\u00a0IgA\u00a0may provide effective immunity against SARS-CoV-2 by inducing mucosal immunity within the respiratory system, a potentially critical feature of an effective vaccine.\u00a0 Ejemel\u00a0et al&#8230;.<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/18\/iga-mab-blocks-sars-cov-2-spike-ace2-interaction-providing-mucosal-immunity\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-6914","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6914"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6914\/revisions"}],"predecessor-version":[{"id":6915,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6914\/revisions\/6915"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6914"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6914"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}