{"id":6945,"date":"2020-05-19T13:10:41","date_gmt":"2020-05-19T20:10:41","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6945"},"modified":"2021-03-18T13:12:29","modified_gmt":"2021-03-18T20:12:29","slug":"variation-in-false-negative-rate-of-reverse-transcriptase-polymerase-chain-reaction-based-sars-cov-2-tests-by-time-since-exposure","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/19\/variation-in-false-negative-rate-of-reverse-transcriptase-polymerase-chain-reaction-based-sars-cov-2-tests-by-time-since-exposure\/","title":{"rendered":"Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction-Based SARS-CoV-2 Tests by Time Since Exposure"},"content":{"rendered":"<div class=\"page\" data-page-number=\"2\" data-loaded=\"true\">\n<ul>\n<li class=\"textLayer\">Kucirka et al. found that the probability of a false negative SARS-CoV-2 test result using RT-PCR varied significantly over the disease course. Among 1,330 patients, the false negative rate was lowest between symptom onset (38% false negative rate) and 3 days following symptom onset (20% false negative rate).<\/li>\n<li class=\"textLayer\">Prior to symptom onset, patients had a high probability of receiving a false negative test result (100% at4 days prior to symptom onset, decreasing to 67% at1 day prior to symptom onset). The probability of receiving a false negative increased again 4 days after symptom onset (21%) to 16 days following symptom onset (66%).<\/li>\n<li class=\"textLayer\">These findings suggest that RT-PCR test results for SARS-CoV-2 should be interpreted cautiously, particularly early in the course of infection. Infection should not be ruled out on the basis of RT-PCR alone if clinical and epidemiological evidence is strongly suggestive of SARS-CoV-2 infection.<\/li>\n<\/ul>\n<div class=\"textLayer\"><em>Kucirka et al. (May 13,2020). Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction-Based SARS-CoV-2 Tests by Time Since Exposure. Annals of Internal Medicine. <a href=\"https:\/\/doi.org\/10.7326\/M20-1495\">https:\/\/doi.org\/10.7326\/M20-1495<\/a><\/em><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Kucirka et al. found that the probability of a false negative SARS-CoV-2 test result using RT-PCR varied significantly over the disease course. Among 1,330 patients, the false negative rate was lowest between symptom onset (38% false negative rate) and 3 days following symptom onset (20% false negative rate). Prior to symptom onset, patients had a&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/19\/variation-in-false-negative-rate-of-reverse-transcriptase-polymerase-chain-reaction-based-sars-cov-2-tests-by-time-since-exposure\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-6945","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6945","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6945"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6945\/revisions"}],"predecessor-version":[{"id":6946,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6945\/revisions\/6946"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6945"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6945"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6945"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6945"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}