{"id":6999,"date":"2020-05-20T15:49:13","date_gmt":"2020-05-20T22:49:13","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=6999"},"modified":"2021-03-19T15:50:13","modified_gmt":"2021-03-19T22:50:13","slug":"detection-of-nucleocapsid-antibody-to-sars-cov-2-is-more-sensitive-than-antibody-to-spike-protein-in-covid-19-patients","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/20\/detection-of-nucleocapsid-antibody-to-sars-cov-2-is-more-sensitive-than-antibody-to-spike-protein-in-covid-19-patients\/","title":{"rendered":"Detection of Nucleocapsid Antibody to SARS-CoV-2 Is More Sensitive than Antibody to Spike Protein in COVID-19 Patients"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Luciferase\u00a0immunopreciptation\u00a0assay systems (LIPS) were found to be more sensitive to SARS-CoV-2 specific antibodies to the nucleocapsid than antibodies to the spike protein at<\/span><span data-contrast=\"auto\">\u00a015 or more days after symptom onset<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Sampling daily from patients showed that immunocompromised patients generally had a delayed antibody response.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Though this study only included symptomatic patients<\/span><span data-contrast=\"auto\">, among whom<\/span><span data-contrast=\"auto\">\u00a0antibody levels are likely higher, the high sensitivity of LIPs shows promise and has implications for larger\u00a0seroepidemiologic\u00a0studies.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Burbelo\u00a0et al. (May 19, 2020). Detection of Nucleocapsid Antibody to SARS-CoV-2 Is More Sensitive than Antibody to Spike Protein in COVID-19 Patients. The Journal of Infectious Diseases.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/infdis\/jiaa273\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1093\/infdis\/jiaa273<\/span><\/a><i><span data-contrast=\"none\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Luciferase\u00a0immunopreciptation\u00a0assay systems (LIPS) were found to be more sensitive to SARS-CoV-2 specific antibodies to the nucleocapsid than antibodies to the spike protein at\u00a015 or more days after symptom onset.\u00a0\u00a0 Sampling daily from patients showed that immunocompromised patients generally had a delayed antibody response.\u00a0 Though this study only included symptomatic patients, among whom\u00a0antibody levels are likely&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/20\/detection-of-nucleocapsid-antibody-to-sars-cov-2-is-more-sensitive-than-antibody-to-spike-protein-in-covid-19-patients\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-6999","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=6999"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6999\/revisions"}],"predecessor-version":[{"id":7000,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/6999\/revisions\/7000"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=6999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=6999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=6999"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=6999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}