{"id":702,"date":"2020-09-03T12:39:19","date_gmt":"2020-09-03T19:39:19","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=702"},"modified":"2020-09-08T15:22:24","modified_gmt":"2020-09-08T22:22:24","slug":"covid-19-literature-situation-report-sept-3-2020","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/09\/03\/covid-19-literature-situation-report-sept-3-2020\/","title":{"rendered":"COVID-19 Literature Situation Report Sept. 3, 2020"},"content":{"rendered":"<p>The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.<\/p>\n<p>Today\u2019s summary is based on a review of 423 articles (363 published, 60 in preprint).<\/p>\n<h2>Key Takeaways<\/h2>\n<ul>\n<li>The recombinant nanoparticle vaccine NVX-CoV2373 induced higher anti-spike IgG and neutralizing responses compared to convalescent serum without serious adverse events. <a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2026920\">More<\/a><\/li>\n<li>Use of intravenous treatment with the steroid dexamethasone plus standard care compared with standard care alone resulted in 2.2 more ventilator-free days among patients with COVID-19 who had moderate to severe respiratory failure. <a href=\"https:\/\/doi.org\/10.1001\/jama.2020.17021\">More<\/a><\/li>\n<li>There was a strong dose-response relationship between the frequency of movement and self-reported history of COVID-19. Those who report using public transport or visiting a place of worship more frequently were also more likely to have a history of SARS-CoV-2 infection, even after adjusting for social distancing behaviors. <a href=\"https:\/\/doi.org\/10.1101\/2020.07.29.20164665\">More<\/a><\/li>\n<li>The severity of disease was strongly associated with the likelihood of mounting a robust neutralizing antibody response among patients who had recovered from SARS-CoV-2 infection. <a href=\"https:\/\/doi.org\/10.1038\/s41392-020-00301-9\">More<\/a><\/li>\n<\/ul>\n<div id=\"uw-accordion-shortcode\">\n<h3>Article Summaries<\/h3>\n<div class=\"js-accordion\" data-accordion-prefix-classes=\"uw-accordion-shortcode\">\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\">Non-Pharmaceutical Interventions<\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-708\" class=\"su-post\">\n<h5 class=\"su-post-title\">Timing of State and Territorial COVID-19 Stay-at-Home Orders and Changes in Population Movement \u2014 United States<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li>Based on location data from mobile devices, mandatory stay-at-home orders issued by states or territories were associated with decreased median population movement compared to the period before orders were implemented. The period after the first state relaxed a stay-at-home order was associated with increased population movement even in states or territories that still had a mandate in place. The analysis included all 50 US states, the District of Columbia, and five US territories.<\/li>\n<\/ul>\n<p><em>Moreland et al. (Sept 4, 2020). Timing of State and Territorial COVID-19 Stay-at-Home Orders and Changes in Population Movement \u2014 United States, March 1\u2013May 31, 2020. MMWR. <a href=\"https:\/\/doi.org\/10.15585\/mmwr.mm6935a2\">https:\/\/doi.org\/10.15585\/mmwr.mm6935a2<\/a><\/em><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-706\" class=\"su-post\">\n<h5 class=\"su-post-title\">Rapid Real-Time Tracking of Non-Pharmaceutical Interventions and Their Association SARS-CoV-2 Positivity: The COVID-19 Pandemic Pulse Study<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li>[Pre-print, not peer reviewed] Clipman et al. found strong dose-response relationships between frequency of movement (e.g. traveling for non-essential services) and self-reported SARS-CoV-2 positivity. Social distancing practices were associated with a lower likelihood of reporting a history of SARS-CoV-2 infection. Travel using public transport and visiting a place of worship were also associated with a history of SARS-CoV-2 infection, even after adjusting for social distancing. These findings were based on sampling of 1,030 individuals in Maryland.<\/li>\n<\/ul>\n<p><em>Clipman et al. (Aug 1, 2020). Rapid Real-Time Tracking of Non-Pharmaceutical Interventions and Their Association SARS-CoV-2 Positivity: The COVID-19 Pandemic Pulse Study. Pre-print downloaded Sep 3 from <a href=\"https:\/\/doi.org\/10.1101\/2020.07.29.20164665\">https:\/\/doi.org\/10.1101\/2020.07.29.20164665<\/a><\/em><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\">Transmission<\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-713\" class=\"su-post\">\n<h5 class=\"su-post-title\">Towards Improved Social Distancing Guidelines Space and Time Dependence of Virus Transmission from Speech-Driven Aerosol Transport Between Two Individuals<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li>[Pre-print, not peer reviewed] A modeling analysis considering air flow and aerosol transport parameters suggests that physical distancing guidelines should also include a contact time recommendation. The authors recommend less than 5 minutes of contact at a distance of one meter apart and less than 15 minutes for two meters apart in scenarios where an asymptomatic individual is speaking to a susceptible individual in a poorly ventilated environment with neither person wearing a mask.<\/li>\n<li>If the asymptomatic individual is a superspreader, the infection risk is high within less than one minute at three meters of separation.<\/li>\n<\/ul>\n<p><em>Yang et al. (Sept 2, 2020). Towards Improved Social Distancing Guidelines Space and Time Dependence of Virus Transmission from Speech-Driven Aerosol Transport Between Two Individuals. Pre-print downloaded Sep 3 from <a href=\"https:\/\/doi.org\/10.1101\/2020.08.31.20185439\">https:\/\/doi.org\/10.1101\/2020.08.31.20185439<\/a><\/em><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\">Testing and Treatment<\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-717\" class=\"su-post\">\n<h5 class=\"su-post-title\">Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li>Intravenous dexamethasone plus standard of care compared with standard care alone resulted in 2.3 days (95%CI 0.02-4.4, p=0.04) more ventilator-free days during the first 28 days in a randomized clinical trial among patients with COVID-19 who had moderate to severe respiratory failure (n=299) in Brazil.<\/li>\n<li>The trial was stopped early before reaching the planned sample size of 350 patients following publication of a related study.<\/li>\n<\/ul>\n<p><em>Tomazini et al. (Sept 2, 2020). Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19. JAMA. <a href=\"https:\/\/doi.org\/10.1001\/jama.2020.17021\">https:\/\/doi.org\/10.1001\/jama.2020.17021<\/a><\/em><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-715\" class=\"su-post\">\n<h5 class=\"su-post-title\">Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li>Administration of hydrocortisone, either as a 7-day fixed-dose course, or dosing only during periods of shock, was associated with being alive and free of ICU-based respiratory or cardiovascular support within 21 days, according to findings of a randomized control trial (n=384) which was stopped early after results were released from another trial. The fixed-dose course and shock-dependent dosing resulted in Bayesian probabilities of superiority of 93% and 80%, respectively.<\/li>\n<\/ul>\n<p><em>Angus et al. (Sept 2, 2020). Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19. JAMA. <a href=\"https:\/\/doi.org\/10.1001\/jama.2020.17022\">https:\/\/doi.org\/10.1001\/jama.2020.17022<\/a><\/em><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\">Vaccines and Immunity<\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-721\" class=\"su-post\">\n<h5 class=\"su-post-title\">Disease Severity Dictates SARS-CoV-2-Specific Neutralizing Antibody Responses in COVID-19<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li>Greater disease severity was associated with higher levels of serum neutralizing capacity among 59 patients recovered from COVID-19 in China. Generation of antibodies capable of completely neutralizing pseudovirus was observed in 80% of patients who recovered from severe illness, while asymptomatic patients failed to generate competent neutralizing antibodies. Complete neutralization was observed in 47% of recovered patients with moderate symptoms and 25% of those with mild symptoms.<\/li>\n<\/ul>\n<p><em>Chen et al. (Sept 2, 2020). Disease Severity Dictates SARS-CoV-2-Specific Neutralizing Antibody Responses in COVID-19. Signal Transduction and Targeted Therapy. <a href=\"https:\/\/doi.org\/10.1038\/s41392-020-00301-9\">https:\/\/doi.org\/10.1038\/s41392-020-00301-9<\/a><\/em><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-719\" class=\"su-post\">\n<h5 class=\"su-post-title\">Phase 1\u20132 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li>NVX-CoV2373, a recombinant nanoparticle vaccine, induced higher levels of anti-spike IgG and neutralizing antibody responses compared to convalescent serum of mostly symptomatic COVID-19 patients. There were no serious adverse events, and events such as fever and sore arm were mild and not long-lasting. These results were from a primary analysis at day 35 of a randomized control trial (n=83).<em> [EDITORIAL NOTE: A summary of a pre-print version of this manuscript appeared in the Lit Rep on August 6]<\/em><\/li>\n<\/ul>\n<p><em>Keech et al. (Sept 2, 2020). Phase 1\u20132 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine. New England Journal of Medicine. <a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2026920\">https:\/\/doi.org\/10.1056\/NEJMoa2026920<\/a><\/em><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\">Mental Health and Personal Impact<\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-723\" class=\"su-post\">\n<h5 class=\"su-post-title\">Risk Factors of Non-Adherence to Guidelines for the Prevention of COVID-19 among Young Adults with Asthma in a Region with a High Risk of a COVID-19 Outbreak<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li>A survey of young people (age 16-24 years; n=2,372) in Mexico found 53% did not adhere to COVID-19 prevention guidelines. Among respondents with asthma, 31% did not comply with basic prevention guidelines. Among those with asthma, male sex, active smoker status, and belief that COVID-19 does not more severely affect people with asthma were associated with non-adherence to guidelines.<\/li>\n<\/ul>\n<p><em>V\u00e1zquez-Nava et al. (Sept 2, 2020). Risk Factors of Non-Adherence to Guidelines for the Prevention of COVID-19 among Young Adults with Asthma in a Region with a High Risk of a COVID-19 Outbreak. Journal of Asthma. <a href=\"https:\/\/doi.org\/10.1080\/02770903.2020.1818774\">https:\/\/doi.org\/10.1080\/02770903.2020.1818774<\/a><\/em><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\">Public Health Policy and Practice<\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-727\" class=\"su-post\">\n<h5 class=\"su-post-title\">SARS-CoV-2 Surveillance in Decedents in a Large Urban Medical Examiner\u2019s Office<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li>[Pre-print, not peer reviewed] The 7-day average percentage of SARS-CoV-2 test positivity among people who had died and were identified as possible recent COVID-19 cases and were posthumously tested (n=237) closely matched the trajectory of percent positivity in the catchment population, according to the Wayne County Medical Examiner&#8217;s office in Michigan.<\/li>\n<li>SARS-CoV-2 positive flagged decedents were more likely to be Black compared to a random sample of known positive decedents (89% vs 51%).<\/li>\n<\/ul>\n<p><em>Brouwer et al. (Aug 7, 2020). SARS-CoV-2 Surveillance in Decedents in a Large Urban Medical Examiner\u2019s Office. Pre-print downloaded Sep 3 from <a href=\"https:\/\/doi.org\/10.1101\/2020.08.03.20162883\">https:\/\/doi.org\/10.1101\/2020.08.03.20162883<\/a><\/em><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-725\" class=\"su-post\">\n<h5 class=\"su-post-title\">Infection Fatality Ratios for COVID-19 Among Noninstitutionalized Persons 12 and Older: Results of a Random-Sample Prevalence Study<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li>The overall infection fatality ratio (IFR) for the state of Indiana, excluding institutionalized persons and children under 12 years of age, was 0.3%. Stratifying the IFR across demographic groups resulted in an IFR of 0.01% among those &lt;40 years of age, 1.7% among those \u226560 years of age, 0.2 among white patients, and 0.6% among non-white patients. The investigators used a statewide non-random sample to obtain 187,802 cumulative infections.<\/li>\n<\/ul>\n<p><em>Blackburn et al. (Sept 2, 2020). Infection Fatality Ratios for COVID-19 Among Noninstitutionalized Persons 12 and Older: Results of a Random-Sample Prevalence Study. Annals of Internal Medicine. <a href=\"https:\/\/doi.org\/10.7326\/M20-5352\">https:\/\/doi.org\/10.7326\/M20-5352<\/a><\/em><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h2>Other Resources and Commentaries<\/h2>\n<ul>\n<li><a href=\"https:\/\/doi.org\/10.3390\/ijerph17176341\">Stigma and Discrimination (SAD) at the Time of the SARS-CoV-2 Pandemic<\/a> \u2013 International Journal of Environmental Research and Public Health (Aug 31)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1136\/bmj.m3169\">Integrating Climate Action for Health into Covid-19 Recovery Plans<\/a> \u2013 BMJ (Sept 2)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.5114\/biolsport.2020.96652\">Return to Football Training and Competition after Lockdown Caused by the COVID-19 Pandemic: Medical Recommendations<\/a> \u2013 Biology of Sport (June 25)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1186\/s40364-020-00217-0\">A Meta-Analysis of Potential Biomarkers Associated with Severity of Coronavirus Disease 2019 (COVID-19)<\/a> \u2013 Biomarker Research (Aug 31)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41467-020-18149-6\">Ocular Conjunctival Inoculation of SARS-CoV-2 Can Cause Mild COVID-19 in Rhesus Macaques<\/a> \u2013 Nature Communications (Sept 2)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1101\/2020.08.31.20185249\">Take-Home Dosing Experiences among Persons Receiving Methadone Maintenance Treatment During COVID-19<\/a> \u2013 medRxiv (Sept 2)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1186\/s40337-020-00317-0\">Association between Eating Behavior and Quarantine\/Confinement Stressors during the Coronavirus Disease 2019 Outbreak<\/a> \u2013 Journal of Eating Disorders (Sept 1)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1089\/jwh.2020.8600\">Women\u2019s Health in Times of Emergency: We Must Take Action<\/a> \u2013 Journal of Women\u2019s Health (Sept 1)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1017\/dmp.2020.318\">An Eye on Covid: Hurricane Preparedness at a COVID-19 Alternative Care Site<\/a> \u2013 Disaster Medicine and Public Health Preparedness (Sept 3)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1590\/0102-311x00150020\">Adolescent Health in the Days of COVID-19: Scoping Review<\/a> \u2013 Cadernos de Sa\u00fade P\u00fablica (Aug 28)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41423-020-00542-2\">Expansion of Atypical Memory B Cells Is a Prominent Feature of COVID-19<\/a> \u2013 Cellular &amp; Molecular Immunology (Sept 2)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1186\/s12916-020-01726-3\">COVID-19 Length of Hospital Stay: A Systematic Review and Data Synthesis<\/a> \u2013 BMC Medicine (Sept 3)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciaa1311\">Healthcare Professionals\u2019 Perceptions of Critical Care Resource Availability and Factors Associated with Mental Well-Being during COVID-19: Results from a US Survey<\/a> \u2013 Clinical Infectious Diseases (Sept 2)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.20104\">Mental Health Inequities in the Context of COVID-19<\/a> \u2013 JAMA Network Open (Sept 2)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1007\/s10461-020-03024-8\">Sex in the Time of COVID-19: Results of an Online Survey of Gay, Bisexual and Other Men Who Have Sex with Men\u2019s Experience of Sex and HIV Prevention During the US COVID-19 Epidemic<\/a> \u2013 AIDS and Behavior (Sept 2)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.3390\/ijerph17176330\">Information on the COVID-19 Pandemic in Daily Newspapers\u2019 Front Pages: Case Study of Spain and Italy<\/a> \u2013 International Journal of Environmental Research and Public Health (Aug 31)<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1093\/jlb\/lsaa036\">Law, Structural Racism, and the COVID-19 Pandemic<\/a> \u2013 Journal of Law and the Biosciences (July 25)<\/li>\n<\/ul>\n<p>Report prepared by the UW MetaCenter for Pandemic Preparedness and Global Health Security and the START Center in collaboration with and on behalf of WA DOH COVID-19 Incident Management Team.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Key Takeaways: The recombinant nanoparticle vaccine NVX-CoV2373 induced higher anti-spike IgG and neutralizing responses compared to convalescent serum without serious adverse events. <\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/09\/03\/infection-fatality-ratios-for-covid-19-among-noninstitutionalized-persons-12-and-older-results-of-a-random-sample-prevalence-study\/\">Read more<\/a><\/div>\n","protected":false},"author":3,"featured_media":348,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[5],"tags":[],"topic":[],"class_list":["post-702","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19-literature-situation-report"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/702","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=702"}],"version-history":[{"count":3,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/702\/revisions"}],"predecessor-version":[{"id":730,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/702\/revisions\/730"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media\/348"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=702"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=702"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=702"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=702"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}