{"id":7035,"date":"2020-05-21T16:11:54","date_gmt":"2020-05-21T23:11:54","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7035"},"modified":"2021-03-19T16:12:44","modified_gmt":"2021-03-19T23:12:44","slug":"systematic-and-statistical-review-of-coronavirus-disease-19-treatment-trials","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/21\/systematic-and-statistical-review-of-coronavirus-disease-19-treatment-trials\/","title":{"rendered":"Systematic and Statistical Review of Coronavirus Disease 19 Treatment Trials"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[<\/span><\/i><i><span data-contrast=\"none\">pre-print, not peer reviewed<\/span><\/i><i><span data-contrast=\"none\">]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Siordia<\/span><span data-contrast=\"auto\">\u00a0et al. conducted a systematic review\u00a0<\/span><span data-contrast=\"auto\">and identified 17<\/span><span data-contrast=\"auto\">\u00a0COVID-19 treatment trials with<\/span><span data-contrast=\"auto\">\u00a0viral clearance and clinical outcomes. Favipiravir had a positive impact on symptoms compared to other medications<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Lopinavir<\/span><span data-contrast=\"auto\">\/ritonavir,\u00a0<\/span><span data-contrast=\"auto\">hydroxychloroquine<\/span><span data-contrast=\"auto\">, and\u00a0<\/span><span data-contrast=\"auto\">arbidol<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">umifenovir<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0had no statistically significant effects<\/span><span data-contrast=\"auto\">\u00a0on viral clearance. There\u00a0<\/span><span data-contrast=\"auto\">was no significant clinical improvement with\u00a0<\/span><span data-contrast=\"auto\">lopinavir<\/span><span data-contrast=\"auto\">\/ritonavir,\u00a0<\/span><span data-contrast=\"auto\">arbidol<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">hydroxychloroquine<\/span><span data-contrast=\"auto\">, or\u00a0<\/span><span data-contrast=\"auto\">remdesivir<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Siord<\/span><\/i><i><span data-contrast=\"none\">ia<\/span><\/i><i><span data-contrast=\"none\">\u00a0et al. (May 20<\/span><\/i><i><span data-contrast=\"none\">,<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><i><span data-contrast=\"none\">2020). Systematic and Statistical Review of Coronavirus Disease 19 Treatment Trials. Pre-print downloaded May 21 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.16.20102095\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.16.20102095<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer reviewed]\u00a0Siordia\u00a0et al. conducted a systematic review\u00a0and identified 17\u00a0COVID-19 treatment trials with\u00a0viral clearance and clinical outcomes. Favipiravir had a positive impact on symptoms compared to other medications.\u00a0Lopinavir\/ritonavir,\u00a0hydroxychloroquine, and\u00a0arbidol\u00a0(umifenovir)\u00a0had no statistically significant effects\u00a0on viral clearance. There\u00a0was no significant clinical improvement with\u00a0lopinavir\/ritonavir,\u00a0arbidol,\u00a0hydroxychloroquine, or\u00a0remdesivir.\u00a0\u00a0 Siordia\u00a0et al. (May 20,\u00a02020). Systematic and Statistical Review of Coronavirus Disease 19&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/21\/systematic-and-statistical-review-of-coronavirus-disease-19-treatment-trials\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_members_access_role":[],"_members_access_error":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7035","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7035","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7035"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7035\/revisions"}],"predecessor-version":[{"id":7036,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7035\/revisions\/7036"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7035"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7035"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7035"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7035"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}