{"id":7058,"date":"2020-05-22T16:23:18","date_gmt":"2020-05-22T23:23:18","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7058"},"modified":"2021-03-19T16:38:42","modified_gmt":"2021-03-19T23:38:42","slug":"covid-19-literature-situation-report-may-22-2020","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/22\/covid-19-literature-situation-report-may-22-2020\/","title":{"rendered":"COVID-19 Literature Situation Report May 22, 2020"},"content":{"rendered":"<p>The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.<\/p>\n<h2>Key Takeaways<\/h2>\n<ul>\n<li><b><span data-contrast=\"auto\">Protective immunity against the spike glycoprotein, the target of many vaccines currently entering clinical trials, was detected after mild to moderate SARS-CoV-2 infection<\/span><\/b><b><span data-contrast=\"auto\">.<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Two studies in an<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><b><span data-contrast=\"auto\">independent living facility (Seattle, WA) and a skilled nursing facility (Los Angeles, CA) found that PCR testing reveals asymptomatic older residents in these settings and that repeated PCR testing identifies new cases. Strict infection control measures are needed to prevent and control outbreaks in these settings.\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Healthcare workers are experiencing a high burden of burnout, depression, anxiety, and insomnia. Burnout is higher among those who feel pushed beyond their training, have exposure to COVID-19 patients, and feel work negatively affects their other life priorities. Adequate PPE availability was associated with lower burnout.\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Google sea<\/span><\/b><b><span data-contrast=\"auto\">rches related to\u00a0<\/span><\/b><b><span data-contrast=\"auto\">purchasing new guns or removing guns from storage<\/span><\/b><b><span data-contrast=\"auto\">\u00a0were 158% higher than expected\u00a0<\/span><\/b><b><span data-contrast=\"auto\">during the first month of the COVID-19\u00a0<\/span><\/b><b><span data-contrast=\"auto\">pandemic in the US\u00a0<\/span><\/b><b><span data-contrast=\"auto\">and 40% higher than<\/span><\/b><b><span data-contrast=\"auto\">\u00a0previous spikes following the Sandy Hook, CT and Parkland, FL shootings.<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"4\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">An agent-based model that includes \u201csuperspreaders\u201d finds that limiting diffuse social contacts, while maintaining normal home and work contacts, can halt the epidemic<\/span><\/b><b><span data-contrast=\"auto\">.<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<div id=\"uw-accordion-shortcode\">\n<h3>Article Summaries<\/h3>\n<div class=\"js-accordion\" data-accordion-prefix-classes=\"uw-accordion-shortcode\">\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Testing and Treatment<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7061\" class=\"su-post\">\n<h5 class=\"su-post-title\">Hydroxychloroquine or Chloroquine with or without a Macrolide for Treatment of COVID-19: A Multinational Registry Analysis<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"40\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A multinational registry analysis of the use of hydroxychloroquine or chlor<\/span><span data-contrast=\"auto\">o<\/span><span data-contrast=\"auto\">q<\/span><span data-contrast=\"auto\">u<\/span><span data-contrast=\"auto\">ine, with or without a macrolide (e.g., azithromycin)<\/span><span data-contrast=\"auto\">, included 671 hospitals\u00a0<\/span><span data-contrast=\"auto\">and 96,032 hospitalized patients\u00a0<\/span><span data-contrast=\"auto\">across 6 continents<\/span><span data-contrast=\"auto\">. Patients for whom treatment was not initiated within 48 hours or prior to ventilation were excluded, as were those who received\u00a0remdesivir<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"40\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">After controlling for confounders, including risk factors for severe COVID-19, all four treatment groups were associated with a higher risk of in-hospital mortality, compared with patients who rece<\/span><span data-contrast=\"auto\">ived no treatment: hydroxychloroquine alone HR=1.34 (95%<\/span><span data-contrast=\"auto\">CI 1.22, 1.46)<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">hydroxychloroquine\u00a0with a macrolide\u00a0<\/span><span data-contrast=\"auto\">HR<\/span><span data-contrast=\"auto\">=1.45 (95%<\/span><span data-contrast=\"auto\">CI 1.37, 1.53)<\/span><span data-contrast=\"auto\">, chloroquine alone\u00a0<\/span><span data-contrast=\"auto\">HR<\/span><span data-contrast=\"auto\">=1.37 (95%<\/span><span data-contrast=\"auto\">CI 1.22, 1.53), and\u00a0<\/span><span data-contrast=\"auto\">chloroquine with a macrolide\u00a0<\/span><span data-contrast=\"auto\">HR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">1.37 (95% CI 1.27, 1.47).\u00a0<\/span><span data-contrast=\"auto\">All four treatments were also associated with\u00a0strong\u00a0increased risk<\/span><span data-contrast=\"auto\">\u00a0of de-novo ventricular arrhythmias<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Mehra et al. Hydroxychloroquine or Chloroquine with or without a Macrolide for Treatment of COVID-19: A Multinational Registry Analysis. The Lancet<\/span><\/i><i><span data-contrast=\"auto\">.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(20)31180-6\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/S0140-6736(20)31180-6<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Vaccine<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7063\" class=\"su-post\">\n<h5 class=\"su-post-title\">Immunogenic Profile of SARS-CoV-2 Spike in Individuals Recovered from COVID-19<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"39\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[<\/span><\/i><i><span data-contrast=\"none\">pre-print, not peer reviewed<\/span><\/i><i><span data-contrast=\"none\">]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Juno et al.\u00a0<\/span><span data-contrast=\"auto\">found\u00a0<\/span><span data-contrast=\"auto\">that follo<\/span><span data-contrast=\"auto\">wing mild to moderate\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2 infection, antibody responses against the viral spike protein are routinely elicited and that they are correlate with the ability of blood plasma to block binding to the ACE2 receptor. This has positive implications for vaccine development because s<\/span><span data-contrast=\"auto\">everal COVID-19 vaccine candidates\u00a0<\/span><span data-contrast=\"auto\">that<\/span><span data-contrast=\"auto\">\u00a0are now entering clinical trials are designed to elicit antibodies<\/span><span data-contrast=\"auto\">\u00a0that\u00a0<\/span><span data-contrast=\"auto\">target\u00a0the viral\u00a0spike glycoprotein.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Juno et al. (May 21, 2020). Immunogenic Profile of SARS-CoV-2 Spike in Individuals Recovered from COVID-19.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print\u00a0downloaded May 21 from<\/span><\/i><i><span data-contrast=\"auto\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.17.20104869\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.17.20104869<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Clinical Characteristics and Health Care Setting<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7069\" class=\"su-post\">\n<h5 class=\"su-post-title\">Clinical Predictors of COVID-19 Mortality<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"39\" data-aria-posinset=\"2\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[<\/span><\/i><i><span data-contrast=\"none\">pre-print, not peer reviewed<\/span><\/i><i><span data-contrast=\"none\">]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Machine learning techniques\u00a0<\/span><span data-contrast=\"auto\">were\u00a0<\/span><span data-contrast=\"auto\">applied to clinical data from a cohort of 5,051 COVID-19 patients in New York City to predict mortality<\/span><span data-contrast=\"auto\">\u00a0(<\/span><span data-contrast=\"auto\">training set of\u00a0n=3,841<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0A mortality predictor based on five clinical features (age, minimum oxygen saturation, type of encounter, hydroxychloroquine use, and maximum body temperature)\u00a0<\/span><span data-contrast=\"auto\">had good predictive performance (<\/span><span data-contrast=\"auto\">AUC<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">0.91<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0on a test set of\u00a0retrospective\u00a0(n=961) and prospective (n=249) patients.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Yadaw\u00a0et al. (May 22, 2020). Clinical Predictors of COVID-19 Mortality.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print\u00a0downloaded May 21 from<\/span><\/i><i><span data-contrast=\"auto\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.19.20103036\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.19.20103036<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7067\" class=\"su-post\">\n<h5 class=\"su-post-title\">Characterization of Patients Who Return to Hospital Following Discharge from Hospitalization For COVID-19<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"39\" data-aria-posinset=\"2\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[<\/span><\/i><i><span data-contrast=\"none\">pre-print, not peer reviewed<\/span><\/i><i><span data-contrast=\"none\">]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">A retrospective cohort\u00a0<\/span><span data-contrast=\"auto\">of 2,864 COVID-19 patients discharged from five New York City hospitals\u00a0<\/span><span data-contrast=\"auto\">found 103 (3.6%) returned for emerge<\/span><span data-contrast=\"auto\">ncy care after a median of 4.5 d<\/span><span data-contrast=\"auto\">ays, with 56 requiring re<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">admission<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">In 50% of cases t<\/span><span data-contrast=\"auto\">he reason for return was respiratory distress<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"39\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">P<\/span><span data-contrast=\"auto\">atients who returned had a higher burden of COPD and hypertension,\u00a0<\/span><span data-contrast=\"auto\">had a shorter duration of index hospitalization, and\u00a0<\/span><span data-contrast=\"auto\">were less likely to require intensive care<\/span><span data-contrast=\"auto\">\u00a0or to have received anticoagulation<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">during index hospitalization<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"auto\">Among those readmitted, 5.8% required intensive care, and 3.6% died.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Somani et al. (May 22, 2020). Characterization of Patients Who Return to Hospital Following Discharge from Hospitalization For COVID-19.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print\u00a0downloaded May 21 from<\/span><\/i><i><span data-contrast=\"auto\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.17.20104604\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.17.20104604<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7065\" class=\"su-post\">\n<h5 class=\"su-post-title\">Development and Implementation of a Clinician-Facing Prognostic Communication Tool for Patients with COVID-19 and Critical Illness<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"39\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Survival data and descriptions of best- and worst-case clinical scenario<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">\u00a0were used to create an online COVID-19 Prognostication Tool.\u00a0<\/span><span data-contrast=\"auto\">The<\/span><span data-contrast=\"auto\">\u00a0visual infographic tool includes prompts for clinician reflect<\/span><span data-contrast=\"auto\">ion<\/span><span data-contrast=\"auto\">\u00a0to enhance awareness of cognitive biases\u00a0<\/span><span data-contrast=\"auto\">that<\/span><span data-contrast=\"auto\">\u00a0may\u00a0<\/span><span data-contrast=\"auto\">affect their\u00a0<\/span><span data-contrast=\"auto\">prognostic accuracy.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Gibbon et al. (May 2020). Development and Implementation of a Clinician-Facing Prognostic Communication Tool for Patients with COVID-19 and Critical Illness. Journal of Pain and Symptom Management.<\/span><\/i><i><span data-contrast=\"auto\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.jpainsymman.2020.05.005\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.jpainsymman.2020.05.005<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW150487578 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW150487578 BCX0\" data-ccp-parastyle=\"heading 2\">Mental Health and Personal Impact<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7073\" class=\"su-post\">\n<h5 class=\"su-post-title\">Prevalence of Depression, Anxiety, and Insomnia among Healthcare Workers during the COVID-19 Pandemic:\u00a0A Systematic\u00a0Review and Meta-Analysis<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"38\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A systematic literature review<\/span><span data-contrast=\"auto\">\u00a0that\u00a0<\/span><span data-contrast=\"auto\">included 13 studies<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0corresponding to 33,062\u00a0<\/span><span data-contrast=\"auto\">healthcare workers<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">found a\u00a0<\/span><span data-contrast=\"auto\">pooled prevalence of anxiety of 23%, depression of 23<\/span><span data-contrast=\"auto\">%, and\u00a0<\/span><span data-contrast=\"auto\">of insomnia of\u00a0<\/span><span data-contrast=\"auto\">3<\/span><span data-contrast=\"auto\">9<\/span><span data-contrast=\"auto\">%.\u00a0<\/span><span data-contrast=\"auto\">F<\/span><span data-contrast=\"auto\">emale providers and nurses had a higher prevalence\u00a0of\u00a0<\/span><span data-contrast=\"auto\">these outcomes<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">A<\/span><span data-contrast=\"auto\">\u00a0considerable proportion of healthcare workers are experiencing mood and sleep disturbances during the COVID-19 pandemic.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Pappa et al. (May 2020). Prevalence of Depression, Anxiety, and Insomnia among Healthcare Workers during the COVID-19 Pandemic:\u00a0A Systematic\u00a0Review and Meta-Analysis. Brain, Behavior, and Immunity.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.bbi.2020.05.026\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.bbi.2020.05.026<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7071\" class=\"su-post\">\n<h5 class=\"su-post-title\">Factors Contributing to Healthcare Professional Burnout During the COVID-19 Pandemic A Rapid Turnaround Global Survey<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"38\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[<\/span><\/i><i><span data-contrast=\"none\">pre-print, not peer reviewed<\/span><\/i><i><span data-contrast=\"none\">]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">A cross-sectional study of over 2,500 healthcare professionals from 60 countries found 50% self-reported burnout. Burnout was found to be associated with work impacting household activitie<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">, fee<\/span><span data-contrast=\"auto\">ling pushed beyond training<\/span><span data-contrast=\"auto\">, exposure to COVID-19 p<\/span><span data-contrast=\"auto\">atients<\/span><span data-contrast=\"auto\">, and making life prioritizing decisions\u00a0<\/span><span data-contrast=\"auto\">due to supply shortages<\/span><span data-contrast=\"auto\">. Adequate PPE\u00a0<\/span><span data-contrast=\"auto\">was associated with\u00a0lower\u00a0risk of\u00a0<\/span><span data-contrast=\"auto\">burnout.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Morgantini et al. (May 22, 2020). Factors Contributing to Healthcare Professional Burnout During the COVID-19 Pandemic A Rapid Turnaround Global Survey.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print\u00a0downloaded May 21 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.17.20101915\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.17.20101915<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Modeling and Prediction<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7075\" class=\"su-post\">\n<h5 class=\"su-post-title\">Impact of\u00a0Superspreaders\u00a0on Dissemination and Mitigation of COVID-19<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"40\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[<\/span><\/i><i><span data-contrast=\"none\">pre-print, not peer reviewed<\/span><\/i><i><span data-contrast=\"none\">]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Sneppen and Simonsen\u00a0<\/span><span data-contrast=\"auto\">developed a<\/span><span data-contrast=\"auto\">n agent-based model\u00a0<\/span><span data-contrast=\"auto\">that<\/span><span data-contrast=\"auto\">\u00a0includes\u00a0superspreaders\u00a0(persons who spread the disease far more readily than others)<\/span><span data-contrast=\"auto\">\u00a0to\u00a0i<\/span><span data-contrast=\"auto\">nvestigated\u00a0the effect of containment strategies\u00a0<\/span><span data-contrast=\"auto\">under different models of population mixing<\/span><span data-contrast=\"auto\">. They found that limiting contacts in\u00a0<\/span><span data-contrast=\"auto\">settings with\u00a0<\/span><span data-contrast=\"auto\">diffuse social\u00a0<\/span><span data-contrast=\"auto\">interactions,<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">such as\u00a0<\/span><span data-contrast=\"auto\">bars, public transport,\u00a0<\/span><span data-contrast=\"auto\">or\u00a0<\/span><span data-contrast=\"auto\">lecture halls<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0was\u00a0<\/span><span data-contrast=\"auto\">far more effective than limiting<\/span><span data-contrast=\"auto\">\u00a0the same amount of contact<\/span><span data-contrast=\"auto\">\u00a0events in the home and work setting.<\/span><span data-contrast=\"auto\">\u00a0They conclude that\u00a0<\/span><span data-contrast=\"auto\">limiting diffuse social contacts, while maintaining normal home and work contacts,\u00a0<\/span><span data-contrast=\"auto\">could<\/span><span data-contrast=\"auto\">\u00a0halt the epidemic<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Sneppen and Simonsen. (May 21, 2020). Impact of\u00a0Superspreaders\u00a0on Dissemination and Mitigation of COVID-19. Pre-print\u00a0downloaded May 21 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.17.20104745\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.17.20104745<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW58614209 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW58614209 BCX0\" data-ccp-parastyle=\"heading 2\">Public Health Policy and Practice<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7083\" class=\"su-post\">\n<h5 class=\"su-post-title\">Identifying Potential Undocumented COVID-19 Using Publicly Reported Influenza-like-Illness and Laboratory-Confirmed Influenza Disease in the United States: An Approach to Syndromic Surveillance?<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"37\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Using CDC\u00a0FluView\u00a0data,\u00a0<\/span><span data-contrast=\"auto\">Wiemken and\u00a0Shacham\u00a0<\/span><span data-contrast=\"auto\">found a 76% decrease in influenza positive tests and a 27% increase in influenza-like illness in the weeks since COVID-19 was introduced to the US, compared with the previous three influenza seasons. The\u00a0<\/span><span data-contrast=\"auto\">authors<\/span><span data-contrast=\"auto\">\u00a0suggest\u00a0FluView\u00a0could be used for COVID-19\u00a0syndromic\u00a0surveillance.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Wiemken and\u00a0Shacham. (May\u00a02020).\u00a0Identifying Potential Undocumented COVID-19 Using Publicly Reported Influenza-like-Illness and Laboratory-Confirmed Influenza Disease in the United States: An Approach to Syndromic Surveillance? American Journal of Infection Control.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.ajic.2020.05.007\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.ajic.2020.05.007<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7081\" class=\"su-post\">\n<h5 class=\"su-post-title\">Universal and Serial Laboratory Testing for SARS-CoV-2 at a Long-Term Care Skilled Nursing Facility for Veterans \u2014 Los Angeles, California 2020<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"37\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">I<\/span><span data-contrast=\"auto\">n March 2020,\u00a0<\/span><span data-contrast=\"auto\">two residents of a long-term care skilled nursing facility in the Veterans Affairs Greater Los Angeles Healthcare System tested positive for COVID-19. Subsequently, all residents underwent serial (approximately weekly) nasopharyngeal PCR\u00a0testing\u00a0and all clinical\u00a0<\/span><span data-contrast=\"auto\">and nonclinical staff were\u00a0<\/span><span data-contrast=\"auto\">screened through April 10. Positive test results were found in 19 of 99 (19%) residents and 8 of the 136 (6%)<\/span><span data-contrast=\"auto\">\u00a0staff<\/span><span data-contrast=\"auto\">.\u00a0 Fourteen of the 19 residents infected residents were asymptomatic for COVID-19 at the time of testing, among whom 8 developed symptoms after specimen collection<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"37\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">No further cases were identified\u00a0on\u00a0subsequent testing, representing successful containment of the outbreak through case detection by serial PCR testing.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Dora et al. (2020). Universal and Serial Laboratory Testing for SARS-CoV-2 at a Long-Term Care Skilled Nursing Facility for Veterans \u2014 Los Angeles, California 2020<\/span><\/i><i><span data-contrast=\"none\">. MMWR.\u00a0<\/span><\/i><a href=\"http:\/\/dx.doi.org\/10.15585\/mmwr.mm6921e1\"><span data-contrast=\"none\">http:\/\/dx.doi.org\/10.15585\/mmwr.mm6921e1<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7079\" class=\"su-post\">\n<h5 class=\"su-post-title\">Collateral Crises of Gun Preparation and the COVID-19 Pandemic: An\u00a0Infodemiology\u00a0Study<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"37\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Caputi et al.\u00a0<\/span><span data-contrast=\"auto\">used an autoregressive integrated moving average model fit to Google search data from January 2004 to the week that COVID-19 was declared an emergency to predict the expected number of gun preparation searches that would have occurred in the absence of the COVID-19 pandemic. They found a 158% (95%CI 73 to 270%) increase over what was expected during a 34-day period, and a 40% increase over previous spikes following the Sandy Hook, CT and Parkland, FL shootings. The increase in searches was higher in states with greater COVID-19 impacts.\u00a0\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Caputi et al. (May 15, 2020). Collateral Crises of Gun Preparation and the COVID-19 Pandemic: An\u00a0Infodemiology\u00a0Study. JMIR Public Health and Surveillance.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.2196\/19369\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.2196\/19369<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7077\" class=\"su-post\">\n<h5 class=\"su-post-title\">Outbreak Investigation of COVID-19 Among Residents and Staff of an Independent and Assisted Living Community for Older Adults in Seattle, Washington<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li><span data-contrast=\"auto\">In March 2020, public health surveillance of staff and residents at an independent living residence\u00a0<\/span><span data-contrast=\"auto\">for older adults in Seattle, WA<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">revealed\u00a0<\/span><span data-contrast=\"auto\">3 of 80 (3.8%)\u00a0<\/span><span data-contrast=\"auto\">residents (mean age 86 years) and\u00a0<\/span><span data-contrast=\"auto\">2 of\u00a0<\/span><span data-contrast=\"auto\">62\u00a0<\/span><span data-contrast=\"auto\">(3.2%)\u00a0<\/span><span data-contrast=\"auto\">staff<\/span><span data-contrast=\"auto\">\u00a0infected with SARS-CoV-2<\/span><span data-contrast=\"auto\">. None of the three residents\u00a0<\/span><span data-contrast=\"auto\">reported feeling<\/span><span data-contrast=\"auto\">\u00a0ill<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">while\u00a0<\/span><span data-contrast=\"auto\">both staff\u00a0<\/span><span data-contrast=\"auto\">members\u00a0<\/span><span data-contrast=\"auto\">were symptomatic.\u00a0<\/span><span data-contrast=\"auto\">Repeat testing after o<\/span><span data-contrast=\"auto\">ne week<\/span><span data-contrast=\"auto\">\u00a0identified\u00a0<\/span><span data-contrast=\"auto\">one new\u00a0<\/span><span data-contrast=\"auto\">asymptomatic<\/span><span data-contrast=\"auto\">ally infected<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">resident<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">All residents were subsequently isolated for 14 days\u00a0<\/span><span data-contrast=\"auto\">and remained clinically stable.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"37\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">These\u00a0<\/span><span data-contrast=\"auto\">findings<\/span><span data-contrast=\"auto\">\u00a0demonstrate asymptomatic\u00a0<\/span><span data-contrast=\"auto\">detection of SARS-<\/span><span data-contrast=\"auto\">CoV-2 among older adults in an independent\/assisted living community<\/span><span data-contrast=\"auto\">. This highlights the need for continued social\u00a0distancing, strict staff screening, and visitor exclusion in these settings, per current CDC guidance. Symptom screening alone is insufficient to prevent transmission in\u00a0<\/span><span data-contrast=\"auto\">indep<\/span><span data-contrast=\"auto\">endent\/assisted living communities<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Roxby et al. (May 21, 2020). Outbreak Investigation of COVID-19 Among Residents and Staff of an Independent and Assisted Living Community for Older Adults in Seattle, Washington. JAMA Internal Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jamainternmed.2020.2233\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1001\/jamainternmed.2020.2233<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3><strong>Other Resources and Commentaries<\/strong><\/h3>\n<ul>\n<li><a href=\"https:\/\/doi.org\/10.1016\/S2213-2600(20)30234-4\"><span data-contrast=\"none\">COVID-19 and the impact of social determinants of health<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Lancet Respiratory Medicine (May 8)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/doi.org\/10.1001\/jamanetworkopen.2020.9687\"><span data-contrast=\"none\">Estimating coronavirus disease 2019 infection risk in health care workers<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 JAMA Network Open (May 21)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1136\/bmj.m2044\"><span data-contrast=\"none\">World leaders adopt resolution to study WHO&#8217;s response to COVID-19<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 BMJ (May 20)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciaa623\"><span data-contrast=\"none\">Connecting hydroxychloroquine in vitro antiviral activity to in vivo concentration for prediction of antiviral effect: a critical step in treating COVID-19 patients<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Clinical Infectious Diseases (May 21)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1016\/j.cell.2020.04.042\"><span data-contrast=\"none\">Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Cell (May 4)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciaa599\"><span data-contrast=\"none\">Associations of Early COVID-19 Cases in San Francisco with Domestic and International Travel<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Clinical Infectious Diseases (May 21)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li><a href=\"http:\/\/doi.org\/10.1001\/jamainternmed.2020.2224\"><span data-contrast=\"none\">Preventing COVID-19 in Assisted Living Facilities\u2014A Balancing Act<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 JAMA Internal Medicine\u00a0<\/span><br \/>\n<span data-contrast=\"auto\">(May 21)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1038\/s41586-020-2368-8\"><span data-contrast=\"none\">Structure of replicating SARS-CoV-2 polymerase<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Nature (May 21)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Protective immunity against the spike glycoprotein, the target of many vaccines currently entering clinical trials, was detected after mild to moderate SARS-CoV-2 infection. <\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/22\/outbreak-investigation-of-covid-19-among-residents-and-staff-of-an-independent-and-assisted-living-community-for-older-adults-in-seattle-washington\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":1174,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[5],"tags":[],"topic":[],"class_list":["post-7058","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19-literature-situation-report"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7058","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7058"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7058\/revisions"}],"predecessor-version":[{"id":7085,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7058\/revisions\/7085"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media\/1174"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7058"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7058"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7058"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7058"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}