{"id":7061,"date":"2020-05-22T16:25:53","date_gmt":"2020-05-22T23:25:53","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7061"},"modified":"2021-03-19T16:26:41","modified_gmt":"2021-03-19T23:26:41","slug":"hydroxychloroquine-or-chloroquine-with-or-without-a-macrolide-for-treatment-of-covid-19-a-multinational-registry-analysis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/22\/hydroxychloroquine-or-chloroquine-with-or-without-a-macrolide-for-treatment-of-covid-19-a-multinational-registry-analysis\/","title":{"rendered":"Hydroxychloroquine or Chloroquine with or without a Macrolide for Treatment of COVID-19: A Multinational Registry Analysis"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"40\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A multinational registry analysis of the use of hydroxychloroquine or chlor<\/span><span data-contrast=\"auto\">o<\/span><span data-contrast=\"auto\">q<\/span><span data-contrast=\"auto\">u<\/span><span data-contrast=\"auto\">ine, with or without a macrolide (e.g., azithromycin)<\/span><span data-contrast=\"auto\">, included 671 hospitals\u00a0<\/span><span data-contrast=\"auto\">and 96,032 hospitalized patients\u00a0<\/span><span data-contrast=\"auto\">across 6 continents<\/span><span data-contrast=\"auto\">. Patients for whom treatment was not initiated within 48 hours or prior to ventilation were excluded, as were those who received\u00a0remdesivir<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"40\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">After controlling for confounders, including risk factors for severe COVID-19, all four treatment groups were associated with a higher risk of in-hospital mortality, compared with patients who rece<\/span><span data-contrast=\"auto\">ived no treatment: hydroxychloroquine alone HR=1.34 (95%<\/span><span data-contrast=\"auto\">CI 1.22, 1.46)<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">hydroxychloroquine\u00a0with a macrolide\u00a0<\/span><span data-contrast=\"auto\">HR<\/span><span data-contrast=\"auto\">=1.45 (95%<\/span><span data-contrast=\"auto\">CI 1.37, 1.53)<\/span><span data-contrast=\"auto\">, chloroquine alone\u00a0<\/span><span data-contrast=\"auto\">HR<\/span><span data-contrast=\"auto\">=1.37 (95%<\/span><span data-contrast=\"auto\">CI 1.22, 1.53), and\u00a0<\/span><span data-contrast=\"auto\">chloroquine with a macrolide\u00a0<\/span><span data-contrast=\"auto\">HR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">1.37 (95% CI 1.27, 1.47).\u00a0<\/span><span data-contrast=\"auto\">All four treatments were also associated with\u00a0strong\u00a0increased risk<\/span><span data-contrast=\"auto\">\u00a0of de-novo ventricular arrhythmias<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Mehra et al. Hydroxychloroquine or Chloroquine with or without a Macrolide for Treatment of COVID-19: A Multinational Registry Analysis. The Lancet<\/span><\/i><i><span data-contrast=\"auto\">.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(20)31180-6\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/S0140-6736(20)31180-6<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A multinational registry analysis of the use of hydroxychloroquine or chloroquine, with or without a macrolide (e.g., azithromycin), included 671 hospitals\u00a0and 96,032 hospitalized patients\u00a0across 6 continents. Patients for whom treatment was not initiated within 48 hours or prior to ventilation were excluded, as were those who received\u00a0remdesivir.\u00a0\u00a0 After controlling for confounders, including risk factors for&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/22\/hydroxychloroquine-or-chloroquine-with-or-without-a-macrolide-for-treatment-of-covid-19-a-multinational-registry-analysis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7061","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7061","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7061"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7061\/revisions"}],"predecessor-version":[{"id":7062,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7061\/revisions\/7062"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7061"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}