{"id":7092,"date":"2020-05-26T16:42:59","date_gmt":"2020-05-26T23:42:59","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7092"},"modified":"2021-03-19T17:02:04","modified_gmt":"2021-03-20T00:02:04","slug":"remdesivir-for-the-treatment-of-covid-19-preliminary-report","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/26\/remdesivir-for-the-treatment-of-covid-19-preliminary-report\/","title":{"rendered":"Remdesivir\u00a0for the Treatment of Covid-19 &#8211; Preliminary Report"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"38\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A double-blind, randomized, placebo-controlled trial of IV\u00a0remdesivir\u00a0(200mg on day 1, then 100mg daily for up to 9 days) in adults hospitalized with COVID-19 with evidence of lower respiratory tract involvement (n=1,0<\/span><span data-contrast=\"auto\">59<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0found that<\/span><span data-contrast=\"auto\">, compared to placebo,<\/span><span data-contrast=\"auto\">\u00a0recovery was 32% faster in those\u00a0<\/span><span data-contrast=\"auto\">who\u00a0<\/span><span data-contrast=\"auto\">receiv<\/span><span data-contrast=\"auto\">ed<\/span><span data-contrast=\"auto\">\u00a0remdesivir\u00a0(95%CI 12%<\/span><span data-contrast=\"auto\">\u00a0to<\/span><span data-contrast=\"auto\">\u00a055%; median recovery time 11 vs 15 days)<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"38\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Though not statistically significant,\u00a0<\/span><span data-contrast=\"auto\">Remdesivir\u00a0treatment was associated with a slower time to mortality (HR 0.70, 95%CI 0.47<\/span><span data-contrast=\"auto\">\u00a0to\u00a0<\/span><span data-contrast=\"auto\">1.04<\/span><span data-contrast=\"auto\">\u00a0and\u00a0<\/span><span data-contrast=\"auto\">mortality by 14 days\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">7.1% vs 11.9%). Serious adverse events were reported in 21.1% of patients in the\u00a0remdesivir\u00a0group and 27% of patients in the placebo group.\u00a0\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Beigel et al. (May 22, 2020).\u00a0Remdesivir\u00a0for the Treatment of Covid-19 &#8211; Preliminary Report. The N<\/span><\/i><i><span data-contrast=\"none\">ew England Journal of Medicine.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2007764\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1056\/NEJMoa2007764<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A double-blind, randomized, placebo-controlled trial of IV\u00a0remdesivir\u00a0(200mg on day 1, then 100mg daily for up to 9 days) in adults hospitalized with COVID-19 with evidence of lower respiratory tract involvement (n=1,059)\u00a0found that, compared to placebo,\u00a0recovery was 32% faster in those\u00a0who\u00a0received\u00a0remdesivir\u00a0(95%CI 12%\u00a0to\u00a055%; median recovery time 11 vs 15 days).\u00a0\u00a0 Though not statistically significant,\u00a0Remdesivir\u00a0treatment was associated with&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/05\/26\/remdesivir-for-the-treatment-of-covid-19-preliminary-report\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7092","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7092","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7092"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7092\/revisions"}],"predecessor-version":[{"id":7093,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7092\/revisions\/7093"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7092"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7092"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7092"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7092"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}