{"id":7282,"date":"2020-06-02T12:55:44","date_gmt":"2020-06-02T19:55:44","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7282"},"modified":"2021-03-24T12:56:32","modified_gmt":"2021-03-24T19:56:32","slug":"first-case-of-drug%e2%80%90induced-liver-injury-associated-with-the-use-of-tocilizumab-in-a-patient-with-covid%e2%80%9019","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/02\/first-case-of-drug%e2%80%90induced-liver-injury-associated-with-the-use-of-tocilizumab-in-a-patient-with-covid%e2%80%9019\/","title":{"rendered":"First Case of Drug\u2010induced Liver Injury Associated with the Use of Tocilizumab in a Patient with COVID\u201019"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Muhovic et al. present a case of\u00a0<\/span><span data-contrast=\"auto\">probable drug-induced liver injury in\u00a0<\/span><span data-contrast=\"auto\">a\u00a0<\/span><span data-contrast=\"auto\">patient with<\/span><span data-contrast=\"auto\">\u00a0severe COVID-19\u00a0<\/span><span data-contrast=\"auto\">who received tocilizumab<\/span><span data-contrast=\"auto\">. One day after receiving\u00a0<\/span><span data-contrast=\"auto\">the drug, which\u00a0<\/span><span data-contrast=\"auto\">functions<\/span><span data-contrast=\"auto\">\u00a0as an inhibitor of interleukin-6<\/span><span data-contrast=\"auto\">, acute liver injury was verified in laboratory analyses. Biopsy to diagnose drug-induced liver injury was not performed due to the patient&#8217;s fragile condition. The authors suggest\u00a0<\/span><span data-contrast=\"auto\">the need to\u00a0<\/span><span data-contrast=\"auto\">liver function monitoring among COVID-19 patients receiving potentially hepatotoxic drugs.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Muhovi\u0107\u00a0et al. (May 17, 2020). First Case of Drug\u2010induced Liver Injury Associated with the Use of Tocilizumab in a Patient with COVID\u201019. Liver International.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1111\/liv.14516\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1111\/liv.14516<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer reviewed]\u00a0Muhovic et al. present a case of\u00a0probable drug-induced liver injury in\u00a0a\u00a0patient with\u00a0severe COVID-19\u00a0who received tocilizumab. One day after receiving\u00a0the drug, which\u00a0functions\u00a0as an inhibitor of interleukin-6, acute liver injury was verified in laboratory analyses. Biopsy to diagnose drug-induced liver injury was not performed due to the patient&#8217;s fragile condition. The authors suggest\u00a0the need&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/02\/first-case-of-drug%e2%80%90induced-liver-injury-associated-with-the-use-of-tocilizumab-in-a-patient-with-covid%e2%80%9019\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7282","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7282"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7282\/revisions"}],"predecessor-version":[{"id":7283,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7282\/revisions\/7283"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7282"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7282"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}