{"id":7295,"date":"2020-06-03T13:02:23","date_gmt":"2020-06-03T20:02:23","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7295"},"modified":"2021-03-24T13:16:30","modified_gmt":"2021-03-24T20:16:30","slug":"covid-19-literature-situation-report-june-3-2020","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/03\/covid-19-literature-situation-report-june-3-2020\/","title":{"rendered":"COVID-19 Literature Situation Report June 3, 2020"},"content":{"rendered":"<p>The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.<\/p>\n<h2>Key Takeaways<\/h2>\n<ul>\n<li><b><span data-contrast=\"auto\">Today, researchers at the University of Minnesota published results from the first randomized clinical trial\u00a0<\/span><\/b><b><span data-contrast=\"auto\">of<\/span><\/b><b><span data-contrast=\"auto\">\u00a0hydroxychloroquine\u00a0<\/span><\/b><b><span data-contrast=\"auto\">as<\/span><\/b><b><span data-contrast=\"auto\">\u00a0post-exposure\u00a0<\/span><\/b><b><span data-contrast=\"auto\">prophylaxis<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><b><span data-contrast=\"auto\">(PEP) f<\/span><\/b><b><span data-contrast=\"auto\">or<\/span><\/b><b><span data-contrast=\"auto\">\u00a0COVID-19.\u00a0<\/span><\/b><b><span data-contrast=\"auto\">The study found no differences between hydroxychloroquine and placebo in preventing SARS-CoV-2 infection.<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">The\u00a0<\/span><\/b><b><span data-contrast=\"auto\">Lancet and the New England Journal of Medicine both issued\u00a0<\/span><\/b><b><span data-contrast=\"auto\">\u2018<\/span><\/b><b><span data-contrast=\"auto\">Expressions of Concern<\/span><\/b><b><span data-contrast=\"auto\">\u2019<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><b><span data-contrast=\"auto\">regarding<\/span><\/b><b><span data-contrast=\"auto\">\u00a0the validity\u00a0<\/span><\/b><b><span data-contrast=\"auto\">of\u00a0<\/span><\/b><b><span data-contrast=\"auto\">data used\u00a0<\/span><\/b><b><span data-contrast=\"auto\">in<\/span><\/b><b><span data-contrast=\"auto\">\u00a0two articles\u00a0<\/span><\/b><b><span data-contrast=\"auto\">regarding the use of hydroxychloroquine or chloroquine for the treatment of COVID-19<\/span><\/b><b><span data-contrast=\"auto\">. The original articles were\u00a0<\/span><\/b><b><span data-contrast=\"auto\">published by authors associated with a company called\u00a0Surgisphere\u00a0Corporation.<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">An estimated\u00a0<\/span><\/b><b><span data-contrast=\"auto\">33% of healthcare workers at a New York City hospital tested positive for SARS-CoV-2 IgG antibodies. Most of the healthcare workers who tested positive were working in the weeks preceding immunological testing.\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">An estimated 31% of nursing homes in the US had at least one documented COVID-19 case. Nursing homes that were large, urban, and had a higher proportion of\u00a0<\/span><\/b><b><span data-contrast=\"auto\">b<\/span><\/b><b><span data-contrast=\"auto\">lack\u00a0<\/span><\/b><b><span data-contrast=\"auto\">residents had a higher probability of reporting a COVID-19 case.\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<div id=\"uw-accordion-shortcode\">\n<h3>Article Summaries<\/h3>\n<div class=\"js-accordion\" data-accordion-prefix-classes=\"uw-accordion-shortcode\">\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Transmission<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7299\" class=\"su-post\">\n<h5 class=\"su-post-title\">Characteristics of U.S. Nursing Homes with COVID-19 Cases<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Abrams et al. found that 2,949 (31%) of 9,395 nursing homes located in 30 states had at least one documented COVID-19 case. Nursing homes that were large, urban, and had a higher proportion of Black residents had a higher probability of reporting a COVID-19 case.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Abrams et al. (June 2, 2020). Characteristics of U.S. Nursing Homes with COVID-19 Cases. Journal of the American Geriatrics Society.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1111\/jgs.16661\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1111\/jgs.16661<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7297\" class=\"su-post\">\n<h5 class=\"su-post-title\">Early Transmission of SARS-CoV-2 in South Africa:\u00a0An Epidemiological and Phylogenetic Report<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Using genomic surveillance and phylogenetic methods,\u00a0<\/span><span data-contrast=\"auto\">Giandhari\u00a0et al.<\/span><span data-contrast=\"auto\">\u00a0found evidence of multiple international introductions and high rates of SARS-CoV-2 transmission in Western and Eastern Cape regions of South Africa. They also found evidence for\u00a0<\/span><span data-contrast=\"auto\">a\u00a0<\/span><span data-contrast=\"auto\">localized outbreak in a hospital in Durban, potentially explaining the initially high death rates reported in\u00a0<\/span><span data-contrast=\"auto\">th<\/span><span data-contrast=\"auto\">at<\/span><span data-contrast=\"auto\">\u00a0province. This study highlights the\u00a0<\/span><span data-contrast=\"auto\">potential\u00a0<\/span><span data-contrast=\"auto\">role for\u00a0<\/span><span data-contrast=\"auto\">genomic<\/span><span data-contrast=\"auto\">s in the\u00a0<\/span><span data-contrast=\"auto\">surveillance of SARS-CoV-2<\/span><span data-contrast=\"auto\">\u00a0transmission<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Giandhari\u00a0et al. (May 30, 2020). Early Transmission of SARS-CoV-2 in South Africa<\/span><\/i><i><span data-contrast=\"none\">:<\/span><\/i><i><span data-contrast=\"none\">\u00a0An Epidemiological and Phylogenetic Report.\u00a0Preprint\u00a0downloaded\u00a0June\u00a03 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.29.20116376\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.29.20116376<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Testing and Treatment<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7307\" class=\"su-post\">\n<h5 class=\"su-post-title\">Rapid Point of Care Nucleic Acid Testing for SARS-CoV-2 in\u00a0Hospitalised\u00a0Patients\u00a0a Clinical Trial and Implementation Study<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Collier et al. evaluated a point of care (POC) nucleic acid amplification test (NAAT) (called the SAMBA II) for SARS-CoV-2. The sensitivity and specificity of SAMBA II were 96.9% and 99.1%, respectively, and the median time to test result was 2.6 hours. The authors also compared hospital outcomes associated with implementation of POC testing within a large teaching hospital, compared to the standard RT-PCR tests for SARS-<\/span><span data-contrast=\"auto\">Co<\/span><span data-contrast=\"auto\">V<\/span><span data-contrast=\"auto\">-2. Implementation of the SAMBA II POC tests was associated with faster time to triage from the ED, release of isolation rooms, and avoidance of hospital bay closures.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Collier et al. (June 2, 2020). Rapid Point of Care Nucleic Acid Testing for SARS-CoV-2 in\u00a0Hospitalised\u00a0Patients\u00a0a Clinical Trial and Implementation Study.\u00a0Preprint\u00a0downloaded\u00a0June\u00a03 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.31.20114520\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.31.20114520<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7305\" class=\"su-post\">\n<h5 class=\"su-post-title\">Clearance and Persistence of SARS-CoV-2 RNA in COVID-19 Patients<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Carmo et al. found that most patients\u00a0<\/span><span data-contrast=\"auto\">continue to\u00a0<\/span><span data-contrast=\"auto\">test positive for SARS-CoV-2 for over two weeks. The minimum time from first positive to first negative SARS-CoV-2 RT-PCR test result was 7 days, while some patients continued to test positive\u00a0<\/span><span data-contrast=\"auto\">for\u00a0<\/span><span data-contrast=\"auto\">51 days following their first positive test result.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Viral RNA persistence was not associated with\u00a0severity\u00a0of\u00a0disease<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0but\u00a0may be associated with a weaker immune response.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Carmo et al. (June 2, 2020). Clearance and Persistence of SARS-CoV-2 RNA in COVID-19 Patients. Journal of Medical Virology.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1002\/jmv.26103\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1002\/jmv.26103<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7303\" class=\"su-post\">\n<h5 class=\"su-post-title\">Expression of Concern: Hydroxychloroquine or Chloroquine with or without a Macrolide for Treatment of COVID-19: A Multinational Registry Analysis<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">The\u00a0<\/span><span data-contrast=\"auto\">Lancet and the New England Journal of Medicine have both issued Expressions of Concern\u00a0<\/span><span data-contrast=\"auto\">about the validity of the data used for\u00a0<\/span><span data-contrast=\"auto\">two articles<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">regarding the use of h<\/span><span data-contrast=\"auto\">ydroxychloroquine or\u00a0<\/span><span data-contrast=\"auto\">c<\/span><span data-contrast=\"auto\">hloroquine<\/span><span data-contrast=\"auto\">\u00a0for the treatment of COVID-19<\/span><span data-contrast=\"auto\">\u00a0published by\u00a0<\/span><span data-contrast=\"auto\">authors associated with a company\u00a0<\/span><span data-contrast=\"auto\">called\u00a0<\/span><span data-contrast=\"auto\">Surgisphere<\/span><span data-contrast=\"auto\">\u00a0Corporation<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">These articles both utilize<\/span><span data-contrast=\"auto\">d<\/span><span data-contrast=\"auto\">\u00a0retrospective data from an<\/span><span data-contrast=\"auto\">\u00a0international database that included electronic health records from 169 hospitals on three continents<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Editors. (June 3,<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><i><span data-contrast=\"none\">2020). Expression of Concern: Hydroxychloroquine or Chloroquine with or without a Macrolide for Treatment of COVID-19: A Multinational Registry Analysis. The Lancet.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(20)31290-3\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/S0140-6736(20)31290-3<\/span><\/a><i><span data-contrast=\"none\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><i><span data-contrast=\"none\">Rubin. (June 2,\u00a02020).\u00a0Expression of Concern: Mehra MR et Al. Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19. N Engl J Med. DOI: 10.1056\/NEJMoa2007621. The New England Journal of Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMe2020822\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1056\/NEJMe2020822<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7301\" class=\"su-post\">\n<h5 class=\"su-post-title\">A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">A<\/span><span data-contrast=\"auto\">\u00a0place<\/span><span data-contrast=\"auto\">bo-controlled randomized<\/span><span data-contrast=\"auto\">\u00a0trial<\/span><span data-contrast=\"auto\">\u00a0of<\/span><span data-contrast=\"auto\">\u00a0hydroxychloroquine as post<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">exposure prophylaxis\u00a0<\/span><span data-contrast=\"auto\">(PEP)\u00a0<\/span><span data-contrast=\"auto\">for SARS-CoV-2<\/span><span data-contrast=\"auto\">\u00a0found no evidence of efficacy<\/span><span data-contrast=\"auto\">. Among 821 asymptomatic participants, 88% reported a high-risk exposure to a confirmed\u00a0<\/span><span data-contrast=\"auto\">C<\/span><span data-contrast=\"auto\">OVID<\/span><span data-contrast=\"auto\">-19 case<\/span><span data-contrast=\"auto\">. There was no difference in SARS-CoV-2 acquisition between participants receiving hydroxychloroquine (<\/span><span data-contrast=\"auto\">12<\/span><span data-contrast=\"auto\">%) and those receiving placebo (<\/span><span data-contrast=\"auto\">14<\/span><span data-contrast=\"auto\">%)<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">No serious adverse reactions were reported, although side effects were more common with hydroxychloroquine than with placebo (40% vs. 17%).<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Boulware et al. (June 3, 2020)<\/span><\/i><i><span data-contrast=\"none\">\u00a0A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19.\u00a0<\/span><\/i><i><span data-contrast=\"none\">The New England Journal of Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2016638\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1056\/NEJMoa2016638<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7309\" class=\"su-post\">\n<h5 class=\"su-post-title\">Direct Diagnostic Testing of SARS-CoV-2 without the Need for Prior RNA Extraction<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0Wei et al. report on a novel method for nucleic acid amplification testing (NAAT) for point-of-care SARS-CoV-2 diagnostic testing<\/span><span data-contrast=\"auto\">\u00a0[Loop-mediated isothermal amplification (LAMP)]<\/span><span data-contrast=\"auto\">. This assay can be run directly on transport media following a nasopharyngeal swab without requiring an RNA extraction step prior to amplification of the viral\u00a0RNA, and\u00a0provides\u00a0<\/span><span data-contrast=\"auto\">results in 30 minutes. The authors reported a sensitivity of 85% and specificity of 100% based on 10 positive and 10 negative samples.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Wei et al. (June 2, 2020). Direct Diagnostic Testing of SARS-CoV-2 without the Need for Prior RNA Extraction.\u00a0Preprint\u00a0downloaded\u00a0June\u00a03 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.28.20115220\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.28.20115220<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Clinical Characteristics and Health Care Setting<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7315\" class=\"su-post\">\n<h5 class=\"su-post-title\">Prevalence of SARS-CoV-2 Antibodies Among Healthcare Workers at a Tertiary Academic Hospital in New York City<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Mansour et al. found that 33% of 285 healthcare workers at a\u00a0<\/span><span data-contrast=\"auto\">t<\/span><span data-contrast=\"auto\">ertiary\u00a0<\/span><span data-contrast=\"auto\">a<\/span><span data-contrast=\"auto\">cademic\u00a0<\/span><span data-contrast=\"auto\">h<\/span><span data-contrast=\"auto\">ospital in New York City tested positive for SARS-CoV-2 IgG antibodies. These findings highlight that inpatient and ambulatory frontline staff had high levels of\u00a0<\/span><span data-contrast=\"auto\">exposure<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">to SARS-CoV-2, most of whom were working in the weeks preceding immunological testing.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Mansour et al. (June 2, 2020). Prevalence of SARS-CoV-2 Antibodies Among Healthcare Workers at a Tertiary Academic Hospital in New York City.\u00a0Preprint\u00a0downloaded\u00a0June\u00a03 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.05.27.20090811\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.05.27.20090811<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7313\" class=\"su-post\">\n<h5 class=\"su-post-title\">ACE-Inhibitors and Angiotensin-2 Receptor Blockers Are Not\u00a0Associated with Severe SARS-COVID19 Infection in a Multi-Site UK Acute Hospital Trust<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">It has been hypothesized that ACE-inhibitors and\u00a0<\/span><span data-contrast=\"auto\">a<\/span><span data-contrast=\"auto\">ngiotensin<\/span><span data-contrast=\"auto\">-2\u00a0<\/span><span data-contrast=\"auto\">b<\/span><span data-contrast=\"auto\">lockers<\/span><span data-contrast=\"auto\">, medications commonly prescribed to patients with hypertension or diabetes,\u00a0<\/span><span data-contrast=\"auto\">could\u00a0<\/span><span data-contrast=\"auto\">increase the risk of severe COVID-19 infection\u00a0<\/span><span data-contrast=\"auto\">by increasing the number of ACE2 receptors that<\/span><span data-contrast=\"auto\">\u00a0SARS-<\/span><span data-contrast=\"auto\">Co<\/span><span data-contrast=\"auto\">V<\/span><span data-contrast=\"auto\">-2\u00a0<\/span><span data-contrast=\"auto\">uses\u00a0<\/span><span data-contrast=\"auto\">for cell entry. However, Bean et al. found no evidence for increased risk of ICU admission or death\u00a0<\/span><span data-contrast=\"auto\">associated with these medications\u00a0<\/span><span data-contrast=\"auto\">in a cohort of 1,200 hospitalized COVID-19 patients.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Bean et al. (June 2, 2020). ACE-Inhibitors and Angiotensin-2 Receptor Blockers Are Not\u00a0<\/span><\/i><i><span data-contrast=\"none\">Associated with Severe SARS-COVID19 Infection in a Multi-Site UK Acute Hospital Trust. European Journal of Heart Failure.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1002\/ejhf.1924\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1002\/ejhf.1924<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7311\" class=\"su-post\">\n<h5 class=\"su-post-title\">Lymphopenia in Severe Coronavirus Disease-2019 (COVID-19): Systematic Review and Meta-Analysis<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Huang and Pranata conducted a meta-analysis of lymphocyte count and severity of COVID-19 disease. Results from 24 studies suggest that patients with poor clinical outcomes have a lower lymphocyte count (mean difference &#8211; 361.06\u00a0\u03bcL) compared to those with good outcomes. This finding persisted in subgroup analysis, which revealed lower lymphocyte counts in patients who died, experienced acute respiratory distress syndrome, and were admitted to ICU. Lymphopenia was significantly associated with severe COVID-19 (OR 3.70, 95%CI: 2.44, 5.63)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Huang and Pranata. (May 24,\u00a02020).\u00a0Lymphopenia in Severe Coronavirus Disease-2019 (COVID-19): Systematic Review and Meta-Analysis. Journal of Intensive Care.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1186\/s40560-020-00453-4\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1186\/s40560-020-00453-4<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW123896879 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW123896879 BCX0\" data-ccp-parastyle=\"heading 2\">Mental Health and Personal Impact<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7317\" class=\"su-post\">\n<h5 class=\"su-post-title\">COVID-19 Pandemic and Mental Health Consequences: Systematic Review of\u00a0the Current\u00a0Evidence<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">In a systematic review of the mental health consequences of the SARS-CoV-2 pandemic, Vindegaard and\u00a0Benros\u00a0found only 2 studies\u00a0<\/span><span data-contrast=\"auto\">that\u00a0<\/span><span data-contrast=\"auto\">evaluated patients with confirmed COVID-19 infection. These studies reported a high level of post-traumatic stress symptoms (96%) and depressive symptoms among COVID-19 patients.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">The remaining 41 studies focused on the indirect effects of the pandemic on healthcare workers, the general public, and on those with existing mental health diagnoses.\u00a0<\/span><span data-contrast=\"auto\">In the general public, w<\/span><span data-contrast=\"auto\">omen, individuals\u00a0<\/span><span data-contrast=\"auto\">with\u00a0<\/span><span data-contrast=\"auto\">poor<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">self-<\/span><span data-contrast=\"auto\">rated\u00a0<\/span><span data-contrast=\"auto\">health<\/span><span data-contrast=\"auto\">\u00a0status,<\/span><span data-contrast=\"auto\">\u00a0and\u00a0<\/span><span data-contrast=\"auto\">those with\u00a0<\/span><span data-contrast=\"auto\">relatives with COVID-19 were\u00a0<\/span><span data-contrast=\"auto\">more likely to\u00a0<\/span><span data-contrast=\"auto\">self-report anxiety<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0depression symptoms<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0or low psychological well-being.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Vindegaard and\u00a0Benros. (May 30,\u00a02020).\u00a0COVID-19 Pandemic and Mental Health Consequences: Systematic Review of\u00a0the Current\u00a0Evidence. Brain, Behavior, and Immunity.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.bbi.2020.05.048\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.bbi.2020.05.048<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span class=\"TextRun SCXW58614209 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW58614209 BCX0\" data-ccp-parastyle=\"heading 2\">Public Health Policy and Practice<\/span><\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7319\" class=\"su-post\">\n<h5 class=\"su-post-title\">Feeling Positive About Reopening? New Normal Scenarios from COVID-19 Reopen Sentiment Analytics<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Samuel et al. used Twitter data to analyze public sentiment\u00a0<\/span><span data-contrast=\"auto\">to<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">identify dominant opinions associated with the push to &#8216;reopen&#8217; the economy following COVID-19 stay-at-home orders. Between April 30 and May 8, 2020, Twitter users\u00a0<\/span><span data-contrast=\"auto\">show<\/span><span data-contrast=\"auto\">ed<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">more positive\u00a0<\/span><span data-contrast=\"auto\">than negative\u00a0<\/span><span data-contrast=\"auto\">sentiment support for reopening the US economy. This research\u00a0<\/span><span data-contrast=\"auto\">provides some indication that\u00a0<\/span><span data-contrast=\"auto\">emotional volatility\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">presence of extreme fear, confusion, trust<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0and anticipation<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">is\u00a0<\/span><span data-contrast=\"auto\">associated with the COVID-19 pandemic and the socioeconomic consequences of the lockdown.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Samuel et al. (June 2, 2020). Feeling Positive About Reopening? New Normal Scenarios from COVID-19 Reopen Sentiment Analytics.\u00a0Preprint\u00a0downloaded\u00a0June\u00a03 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.06.01.20119362\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.06.01.20119362<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3><strong>Other Resources and Commentaries<\/strong><\/h3>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"1\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1021\/acsinfecdis.0c00236\"><span data-contrast=\"none\">Current Perspective of Antiviral Strategies against COVID-19<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 ACS Infectious Diseases (June 2)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.7326\/M20-1851\"><span data-contrast=\"none\">Th<\/span><span data-contrast=\"none\">e<\/span><span data-contrast=\"none\">\u00a0Collision of COVID-19 and the U.S. Health System<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Annals of Internal Medicine (June 2<\/span><span data-contrast=\"auto\">)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"3\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1021\/acscentsci.0c00489\"><span data-contrast=\"none\">Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013\u00a0<\/span><span data-contrast=\"auto\">ACS Central Science<\/span><span data-contrast=\"auto\">\u00a0(May\u00a0<\/span><span data-contrast=\"auto\">4<\/span><span data-contrast=\"auto\">)\u00a0<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"4\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1016\/j.medcli.2020.05.002\"><span data-contrast=\"none\">Research during SARS-CoV-2 Pandemic: To \u201cPreprint\u201d or Not to \u201cPreprint\u201d, That Is the Question<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013\u00a0<\/span><span data-contrast=\"auto\">Medicina Clinica<\/span><span data-contrast=\"auto\">\u00a0(May\u00a0<\/span><span data-contrast=\"auto\">8<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"5\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1080\/15265161.2020.1764145\"><span data-contrast=\"none\">Positive Public Health Ethics: Toward Flourishing and Resilient Communities and Individuals<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013\u00a0<\/span><span data-contrast=\"auto\">The American Journal of Bioethics<\/span><span data-contrast=\"auto\">\u00a0(June 2)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"1\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1186\/s13020-020-00326-w\"><span data-contrast=\"none\">The Potential Insights of Traditional Chinese Medicine on Treatment of COVID-19<\/span><\/a><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">\u2013<\/span><span data-contrast=\"auto\">\u00a0Chinese Medicine<\/span><span data-contrast=\"auto\">\u00a0(May 24)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1136\/bmj.m2192\"><span data-contrast=\"none\">Covid-19: Doctors Need Proper Mental Health Support<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013<\/span><span data-contrast=\"auto\">\u00a0BMJ<\/span><span data-contrast=\"auto\">\u00a0(June 1)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Today, researchers at the University of Minnesota published results from the first randomized clinical trial of hydroxychloroquine as post-exposure prophylaxis (PEP) for COVID-19. The study found no differences between hydroxychloroquine and placebo in preventing SARS-CoV-2 infection. <\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/03\/feeling-positive-about-reopening-new-normal-scenarios-from-covid-19-reopen-sentiment-analytics\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":347,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[5],"tags":[],"topic":[],"class_list":["post-7295","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19-literature-situation-report"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7295"}],"version-history":[{"count":2,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7295\/revisions"}],"predecessor-version":[{"id":7322,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7295\/revisions\/7322"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media\/347"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7295"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}