{"id":7311,"date":"2020-06-03T13:10:59","date_gmt":"2020-06-03T20:10:59","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7311"},"modified":"2021-03-24T13:11:42","modified_gmt":"2021-03-24T20:11:42","slug":"lymphopenia-in-severe-coronavirus-disease-2019-covid-19-systematic-review-and-meta-analysis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/03\/lymphopenia-in-severe-coronavirus-disease-2019-covid-19-systematic-review-and-meta-analysis\/","title":{"rendered":"Lymphopenia in Severe Coronavirus Disease-2019 (COVID-19): Systematic Review and Meta-Analysis"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Huang and Pranata conducted a meta-analysis of lymphocyte count and severity of COVID-19 disease. Results from 24 studies suggest that patients with poor clinical outcomes have a lower lymphocyte count (mean difference &#8211; 361.06\u00a0\u03bcL) compared to those with good outcomes. This finding persisted in subgroup analysis, which revealed lower lymphocyte counts in patients who died, experienced acute respiratory distress syndrome, and were admitted to ICU. Lymphopenia was significantly associated with severe COVID-19 (OR 3.70, 95%CI: 2.44, 5.63)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Huang and Pranata. (May 24,\u00a02020).\u00a0Lymphopenia in Severe Coronavirus Disease-2019 (COVID-19): Systematic Review and Meta-Analysis. Journal of Intensive Care.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1186\/s40560-020-00453-4\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1186\/s40560-020-00453-4<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Huang and Pranata conducted a meta-analysis of lymphocyte count and severity of COVID-19 disease. Results from 24 studies suggest that patients with poor clinical outcomes have a lower lymphocyte count (mean difference &#8211; 361.06\u00a0\u03bcL) compared to those with good outcomes. This finding persisted in subgroup analysis, which revealed lower lymphocyte counts in patients who died,&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/03\/lymphopenia-in-severe-coronavirus-disease-2019-covid-19-systematic-review-and-meta-analysis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-7311","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7311"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7311\/revisions"}],"predecessor-version":[{"id":7312,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7311\/revisions\/7312"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7311"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}