{"id":7331,"date":"2020-06-04T13:23:30","date_gmt":"2020-06-04T20:23:30","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7331"},"modified":"2021-03-24T13:24:17","modified_gmt":"2021-03-24T20:24:17","slug":"effect-of-convalescent-plasma-therapy-on-time-to-clinical-improvement-in-patients-with-severe-and-life-threatening-covid-19-a-randomized-clinical-trial","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/04\/effect-of-convalescent-plasma-therapy-on-time-to-clinical-improvement-in-patients-with-severe-and-life-threatening-covid-19-a-randomized-clinical-trial\/","title":{"rendered":"Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients\u00a0With\u00a0Severe and Life-Threatening COVID-19: A Randomized Clinical Trial"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Li et al. conducted a multicenter\u00a0<\/span><span data-contrast=\"auto\">randomized trial of convalescent plasma therapy among\u00a0<\/span><span data-contrast=\"auto\">103 participants with\u00a0<\/span><span data-contrast=\"auto\">\u201c<\/span><span data-contrast=\"auto\">severe<\/span><span data-contrast=\"auto\">\u201d<\/span><span data-contrast=\"auto\">\u00a0or\u00a0<\/span><span data-contrast=\"auto\">\u201c<\/span><span data-contrast=\"auto\">life-threatening<\/span><span data-contrast=\"auto\">\u201d<\/span><span data-contrast=\"auto\">\u00a0COVID-19 in Wuhan, China.<\/span><span data-contrast=\"auto\">\u00a0The\u00a0<\/span><span data-contrast=\"auto\">trial was\u00a0<\/span><span data-contrast=\"auto\">stopped<\/span><span data-contrast=\"auto\">\u00a0early, which resulted in insufficient power to fully evaluate the primary outcomes.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Overall,\u00a0<\/span><span data-contrast=\"auto\">there were no statistically significant differences in clinical improvement within 28 days between those who did and did not receive convalescent plasma.\u00a0<\/span><span data-contrast=\"auto\">However<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0an accompanying\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1001\/jama.2020.10218\"><span data-contrast=\"none\">editorial<\/span><\/a><span data-contrast=\"auto\">\u00a0points to promising trends\u00a0<\/span><span data-contrast=\"auto\">among those\u00a0<\/span><span data-contrast=\"auto\">who received<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">convalescent\u00a0<\/span><span data-contrast=\"auto\">plasma. This is particularly true of the finding that among those with\u00a0<\/span><span data-contrast=\"auto\">\u201c<\/span><span data-contrast=\"auto\">severe<\/span><span data-contrast=\"auto\">\u201d<\/span><span data-contrast=\"auto\">\u00a0disease (as opposed to the more se<\/span><span data-contrast=\"auto\">rious<\/span><span data-contrast=\"auto\">\u00a0group with \u201clife-threatening\u201d disease)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">c<\/span><span data-contrast=\"auto\">linical improvement occurred within 28 days\u00a0<\/span><span data-contrast=\"auto\">among<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">91.3% (21\/23)\u00a0<\/span><span data-contrast=\"auto\">of those who receive<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">convalescent plasma compared to\u00a0<\/span><span data-contrast=\"auto\">68.2% (15\/22)<\/span><span data-contrast=\"auto\">\u00a0of those in the control group (<\/span><span data-contrast=\"auto\">p=<\/span><span data-contrast=\"auto\">0<\/span><span data-contrast=\"auto\">.03<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Li et al. (June 3, 2020). Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients\u00a0With\u00a0Severe and Life-Threatening COVID-19: A Randomized Clinical Trial. JAMA.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jama.2020.10044\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1001\/jama.2020.10044<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Li et al. conducted a multicenter\u00a0randomized trial of convalescent plasma therapy among\u00a0103 participants with\u00a0\u201csevere\u201d\u00a0or\u00a0\u201clife-threatening\u201d\u00a0COVID-19 in Wuhan, China.\u00a0The\u00a0trial was\u00a0stopped\u00a0early, which resulted in insufficient power to fully evaluate the primary outcomes.\u00a0 Overall,\u00a0there were no statistically significant differences in clinical improvement within 28 days between those who did and did not receive convalescent plasma.\u00a0However,\u00a0an accompanying\u00a0editorial\u00a0points to promising trends\u00a0among&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/04\/effect-of-convalescent-plasma-therapy-on-time-to-clinical-improvement-in-patients-with-severe-and-life-threatening-covid-19-a-randomized-clinical-trial\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7331","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7331"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7331\/revisions"}],"predecessor-version":[{"id":7332,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7331\/revisions\/7332"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7331"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7331"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7331"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}