{"id":7398,"date":"2020-06-08T15:40:57","date_gmt":"2020-06-08T22:40:57","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7398"},"modified":"2021-03-24T15:41:40","modified_gmt":"2021-03-24T22:41:40","slug":"side-by-side-comparison-of-three-fully-automated-sars-cov-2-antibody-assays-with-a-focus-on-specificity","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/08\/side-by-side-comparison-of-three-fully-automated-sars-cov-2-antibody-assays-with-a-focus-on-specificity\/","title":{"rendered":"Side by Side Comparison of Three Fully Automated SARS-CoV-2 Antibody Assays with a Focus on Specificity"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"36\" data-aria-posinset=\"2\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Comparison of the Abbott, Roche, and DiaSorin antibody assays found high specificity for all three (ranging from 98.3% to 99.2%). However, when seroprevalence is low, even these high specificities can result in very low positive predictive values (32.6% to 77.6% at 1% prevalence). Sensitivity was found to be lower than reported by the manufacturers (ranging from 83.1% to 89.2%) and the Roche and DiaSorin tests were most likely to disagree with each other.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Perkmann\u00a0et al. (June 5, 2020). Side by Side Com<\/span><\/i><i><span data-contrast=\"none\">parison of Three Fully Automated SARS-CoV-2 Antibody Assays with a Focus on Specificity.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print\u00a0downloaded\u00a0June\u00a0<\/span><\/i><i><span data-contrast=\"none\">8<\/span><\/i><i><span data-contrast=\"none\">\u00a0from<\/span><\/i><i><span data-contrast=\"none\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.06.04.20117911\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.06.04.20117911<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer reviewed]\u00a0Comparison of the Abbott, Roche, and DiaSorin antibody assays found high specificity for all three (ranging from 98.3% to 99.2%). However, when seroprevalence is low, even these high specificities can result in very low positive predictive values (32.6% to 77.6% at 1% prevalence). Sensitivity was found to be lower than reported by&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/08\/side-by-side-comparison-of-three-fully-automated-sars-cov-2-antibody-assays-with-a-focus-on-specificity\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7398","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7398","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7398"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7398\/revisions"}],"predecessor-version":[{"id":7399,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7398\/revisions\/7399"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7398"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7398"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7398"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7398"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}