{"id":7429,"date":"2021-03-23T13:50:00","date_gmt":"2021-03-23T20:50:00","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7429"},"modified":"2021-03-25T13:50:58","modified_gmt":"2021-03-25T20:50:58","slug":"reduced-neutralization-of-sars-cov-2-b-1-1-7-variant-by-convalescent-and-vaccine-sera","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/23\/reduced-neutralization-of-sars-cov-2-b-1-1-7-variant-by-convalescent-and-vaccine-sera\/","title":{"rendered":"Reduced Neutralization of SARS-CoV-2 B.1.1.7 Variant by Convalescent and Vaccine Sera"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The B.1.1.7 variant has a 7-fold higher binding affinity to the angiotensin converting enzyme-2 (ACE2) receptor in human cells than a parent SARS-CoV-2 strain isolated from Wuhan, suggesting a mechanism for the rapid emergence of this variant. Serum from individuals vaccinated with either the Pfizer-BioNTech or the Oxford-AstraZeneca and serum recovered from infection with the Wuhan strain, had only a modest 2-3-fold reduction in neutralization titers against the B.1.1.7 variant. Sera obtained from B.1.1.7-infected individuals show no reduction in titers against the parent strain compared to the B.1.1.7 variant.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Supasa et al.\u00a0(Feb 18, 2021). Reduced Neutralization of SARS-CoV-2 B.1.1.7 Variant by Convalescent and Vaccine Sera. Cell. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.cell.2021.02.033\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/j.cell.2021.02.033<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The B.1.1.7 variant has a 7-fold higher binding affinity to the angiotensin converting enzyme-2 (ACE2) receptor in human cells than a parent SARS-CoV-2 strain isolated from Wuhan, suggesting a mechanism for the rapid emergence of this variant. Serum from individuals vaccinated with either the Pfizer-BioNTech or the Oxford-AstraZeneca and serum recovered from infection with the&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/23\/reduced-neutralization-of-sars-cov-2-b-1-1-7-variant-by-convalescent-and-vaccine-sera\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,33],"topic":[31],"class_list":["post-7429","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7429","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7429"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7429\/revisions"}],"predecessor-version":[{"id":7430,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7429\/revisions\/7430"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7429"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7429"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7429"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7429"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}