{"id":7507,"date":"2020-06-12T14:39:22","date_gmt":"2020-06-12T21:39:22","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7507"},"modified":"2021-03-25T14:40:05","modified_gmt":"2021-03-25T21:40:05","slug":"early-administration-of-lopinavir-ritonavir-plus-hydroxychloroquine-does-not-alter-the-clinical-course-of-sars-cov-2-infection-a-retrospective-cohort-study","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/12\/early-administration-of-lopinavir-ritonavir-plus-hydroxychloroquine-does-not-alter-the-clinical-course-of-sars-cov-2-infection-a-retrospective-cohort-study\/","title":{"rendered":"Early Administration of Lopinavir\/ritonavir plus Hydroxychloroquine Does Not Alter the Clinical Course of SARS-CoV-2 Infection a Retrospective Cohort Study"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"38\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Giacomelli et al. studied early<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">(&lt;5 days from onset of symptoms<\/span><span data-contrast=\"auto\">, n=43<\/span><span data-contrast=\"auto\">) vs. delayed\u00a0<\/span><span data-contrast=\"auto\">(n=129)\u00a0<\/span><span data-contrast=\"auto\">initiation\u00a0<\/span><span data-contrast=\"auto\">of lopinavir\/ritonavir and hydroxychloroquine (LPV\/r + HCQ)<\/span><span data-contrast=\"auto\">\u00a0on\u00a0<\/span><span data-contrast=\"auto\">clinical outcomes by analyzing a cohort of patients with\u00a0<\/span><span data-contrast=\"auto\">COVID-19. All patients meeting the eligibility criteria were offered LPV\/r + HCQ<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">After adjusting for clinical\u00a0<\/span><span data-contrast=\"auto\">factors<\/span><span data-contrast=\"auto\">, the\u00a0<\/span><span data-contrast=\"auto\">odds ratio (<\/span><span data-contrast=\"auto\">OR<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0for 30<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">day mortality was 1.45 (95%CI 0.50, 4.19)<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">Increase\u00a0in hepatic enzymes, nausea, and diarrhea were the most common adverse events.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Giacomelli et al. (June 12, 2020). Early Administration of Lopinavir\/ritonavir plus Hydroxychloroquine Does Not Alter the Clinical Course of SARS-CoV-2 Infection a Retrospective Cohort Study.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print downloaded June 12 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.06.05.20123299\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.06.05.20123299<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer reviewed]\u00a0Giacomelli et al. studied early\u00a0(&lt;5 days from onset of symptoms, n=43) vs. delayed\u00a0(n=129)\u00a0initiation\u00a0of lopinavir\/ritonavir and hydroxychloroquine (LPV\/r + HCQ)\u00a0on\u00a0clinical outcomes by analyzing a cohort of patients with\u00a0COVID-19. All patients meeting the eligibility criteria were offered LPV\/r + HCQ.\u00a0After adjusting for clinical\u00a0factors, the\u00a0odds ratio (OR)\u00a0for 30&#8211;day mortality was 1.45 (95%CI 0.50, 4.19).\u00a0Increase\u00a0in hepatic&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/12\/early-administration-of-lopinavir-ritonavir-plus-hydroxychloroquine-does-not-alter-the-clinical-course-of-sars-cov-2-infection-a-retrospective-cohort-study\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7507","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7507"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7507\/revisions"}],"predecessor-version":[{"id":7508,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7507\/revisions\/7508"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7507"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7507"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7507"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}