{"id":7513,"date":"2020-06-12T14:41:55","date_gmt":"2020-06-12T21:41:55","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7513"},"modified":"2021-03-25T14:42:35","modified_gmt":"2021-03-25T21:42:35","slug":"association-of-asthma-and-its-genetic-predisposition-with-the-risk-of-severe-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/12\/association-of-asthma-and-its-genetic-predisposition-with-the-risk-of-severe-covid-19\/","title":{"rendered":"Association of Asthma and Its Genetic Predisposition with the Risk of Severe COVID-19"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"37\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Individuals with asthma (n=65,677) in the UK Biobank had a significantly higher risk of severe COVID-19\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">a<\/span><span data-contrast=\"auto\">OR=1.39; 95%CI 1.13-1.71),<\/span><span data-contrast=\"auto\">\u00a0c<\/span><span data-contrast=\"auto\">ompared\u00a0<\/span><span data-contrast=\"auto\">to<\/span><span data-contrast=\"auto\">\u00a0those without asthma or COPD<\/span><span data-contrast=\"auto\">\u00a0(n=427,091)<\/span><span data-contrast=\"auto\">, after adjusting for confounders<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">The<\/span><span data-contrast=\"auto\">\u00a0risk\u00a0<\/span><span data-contrast=\"auto\">was\u00a0<\/span><span data-contrast=\"auto\">even greater in those who also had COPD<\/span><span data-contrast=\"auto\">\u00a0(a<\/span><span data-contrast=\"auto\">OR=1.82; 95%CI 1.16-2.86)<\/span><span data-contrast=\"auto\">. On subgroup analysis, this effect was only seen in those with non-allergic asthma.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Zhu et al. (June\u00a0<\/span><\/i><i><span data-contrast=\"none\">6,\u00a0<\/span><\/i><i><span data-contrast=\"none\">2020). Association of Asthma and Its Genetic Predisposition with the Risk of Severe COVID-19. The Journal of Allergy and Clinical Immunology.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.jaci.2020.06.001\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.jaci.2020.06.001<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Individuals with asthma (n=65,677) in the UK Biobank had a significantly higher risk of severe COVID-19\u00a0(aOR=1.39; 95%CI 1.13-1.71),\u00a0compared\u00a0to\u00a0those without asthma or COPD\u00a0(n=427,091), after adjusting for confounders.\u00a0The\u00a0risk\u00a0was\u00a0even greater in those who also had COPD\u00a0(aOR=1.82; 95%CI 1.16-2.86). On subgroup analysis, this effect was only seen in those with non-allergic asthma.\u00a0\u00a0 Zhu et al. (June\u00a06,\u00a02020). Association of Asthma&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/12\/association-of-asthma-and-its-genetic-predisposition-with-the-risk-of-severe-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-7513","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7513"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7513\/revisions"}],"predecessor-version":[{"id":7514,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7513\/revisions\/7514"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7513"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}