{"id":7526,"date":"2020-06-15T14:48:36","date_gmt":"2020-06-15T21:48:36","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7526"},"modified":"2021-03-25T15:05:57","modified_gmt":"2021-03-25T22:05:57","slug":"covid-19-literature-situation-report-june-15-2020","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/15\/covid-19-literature-situation-report-june-15-2020\/","title":{"rendered":"COVID-19 Literature Situation Report June 15, 2020"},"content":{"rendered":"<p>The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.<\/p>\n<h2>Key Takeaways<\/h2>\n<ul>\n<li><b><span data-contrast=\"auto\">A comparison between\u00a0<\/span><\/b><b><span data-contrast=\"auto\">nasal specimens and standard nasopharynx swabs<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><b><span data-contrast=\"auto\">found\u00a0<\/span><\/b><b><span data-contrast=\"auto\">high concordance (Cohen&#8217;s kappa &gt;0.8)\u00a0<\/span><\/b><b><span data-contrast=\"auto\">for the detection of SARS-CoV-2\u00a0<\/span><\/b><b><span data-contrast=\"auto\">among<\/span><\/b><b><span data-contrast=\"auto\">\u00a0patients with viral loads &gt;1000 copies\/mL.\u00a0<\/span><\/b><b><span data-contrast=\"auto\">Those with viral loads &lt;1000 copies\/mL had low concordance between sample types\u00a0<\/span><\/b><b><span data-contrast=\"auto\">(Cohen\u2019s kappa = 0.49)<\/span><\/b><b><span data-contrast=\"auto\">.<\/span><\/b><a href=\"https:\/\/doi.org\/10.1101\/2020.06.12.20128736\"><b><span data-contrast=\"auto\"> More<\/span><\/b><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">G<\/span><\/b><b><span data-contrast=\"auto\">enetic\u00a0<\/span><\/b><b><span data-contrast=\"auto\">mutations\u00a0<\/span><\/b><b><span data-contrast=\"auto\">of SARS-CoV-2\u00a0<\/span><\/b><b><span data-contrast=\"auto\">could\u00a0<\/span><\/b><b><span data-contrast=\"auto\">diminish<\/span><\/b><b><span data-contrast=\"auto\">\u00a0the<\/span><\/b><b><span data-contrast=\"auto\">\u00a0sensitivity of SARS-CoV-2 PCR assay panels<\/span><\/b><b><span data-contrast=\"auto\">,\u00a0<\/span><\/b><b><span data-contrast=\"auto\">stress<\/span><\/b><b><span data-contrast=\"auto\">ing<\/span><\/b><b><span data-contrast=\"auto\"> the importance of targeting more than one region in the viral genome for SARS-CoV-2 detection due to the unknown mutation rate. <a href=\"https:\/\/doi.org\/10.1016\/j.ijid.2020.06.027\">More<\/a><\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">There\u00a0<\/span><\/b><b><span data-contrast=\"auto\">was\u00a0<\/span><\/b><b><span data-contrast=\"auto\">clinical improvement<\/span><\/b><b><span data-contrast=\"auto\">\u00a0in<\/span><\/b><b><span data-contrast=\"auto\">\u00a011 of 12 patients with severe COVID-19 pneumonia after\u00a0<\/span><\/b><b><span data-contrast=\"auto\">treatment<\/span><\/b><b><span data-contrast=\"auto\">\u00a0with\u00a0lenzilumab<\/span><\/b><b><span data-contrast=\"auto\">. N<\/span><\/b><b><span data-contrast=\"auto\">o<\/span><\/b><b><span data-contrast=\"auto\">\u00a0adverse events<\/span><\/b><b><span data-contrast=\"auto\">\u00a0due to<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><b><span data-contrast=\"auto\">lenzilumab<\/span><\/b><b><span data-contrast=\"auto\">\u00a0were observed<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><b><span data-contrast=\"auto\">and no<\/span><\/b><b><span data-contrast=\"auto\">ne of the\u00a0treated patients\u00a0died<\/span><\/b><b><span data-contrast=\"auto\">.<\/span><\/b><a href=\"https:\/\/doi.org\/10.1101\/2020.06.08.20125369\"><b><span data-contrast=\"auto\"> More<\/span><\/b><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0d8\" data-font=\"Wingdings\" data-listid=\"1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">GPS data from all 50 states and Washington, DC\u00a0<\/span><\/b><b><span data-contrast=\"auto\">indicated<\/span><\/b><b><span data-contrast=\"auto\">\u00a0significant\u00a0<\/span><\/b><b><span data-contrast=\"auto\">increases in social\u00a0distancing\u00a0scores in response to stay-at-home orders<\/span><\/b><b><span data-contrast=\"auto\">,<\/span><\/b><b><span data-contrast=\"auto\">\u00a0and that higher social\u00a0distancing\u00a0scores were associated with lower COVID-19 incidence<\/span><\/b><b><span data-contrast=\"auto\">\u00a0and mortality<\/span><\/b><b><span data-contrast=\"auto\">. <a href=\"https:\/\/doi.org\/10.1101\/2020.06.10.20127589\">More<\/a><\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<div id=\"uw-accordion-shortcode\">\n<h3>Article Summaries<\/h3>\n<div class=\"js-accordion\" data-accordion-prefix-classes=\"uw-accordion-shortcode\">\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Non-Pharmaceutical Interventions<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7530\" class=\"su-post\">\n<h5 class=\"su-post-title\">Effect of Social Distancing on COVID-19 Incidence and Mortality in the US<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Vo<\/span><span data-contrast=\"auto\">Pham\u00a0et al.\u00a0<\/span><span data-contrast=\"auto\">used nationwide smartphone GPS data for 3,054 counties (94%) in all 50 states and Washington, DC, to estimate county-level social distancing based on\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">1) change in average distance traveled (per device),\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">2) change in\u00a0<\/span><span data-contrast=\"auto\">non-essential venue visitation (e.g., hair salons), and\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">3) the probability that two users were in\u00a0clos<\/span><span data-contrast=\"auto\">e\u00a0<\/span><span data-contrast=\"auto\">proximity<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">S<\/span><span data-contrast=\"auto\">tay-at-home orders were associated with a 35% increase in social distancing\u00a0<\/span><span data-contrast=\"auto\">score\u00a0<\/span><span data-contrast=\"auto\">(p&lt;0.001). Higher social distanc<\/span><span data-contrast=\"auto\">ing score was associated with\u00a0<\/span><span data-contrast=\"auto\">29% reduction in COVID-19 incidence (<\/span><span data-contrast=\"auto\">a<\/span><span data-contrast=\"auto\">IRR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">0.71, 95%CI 0.57<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">0.87) and a 35% reduction in COVID-19 mortality (<\/span><span data-contrast=\"auto\">a<\/span><span data-contrast=\"auto\">IRR=<\/span><span data-contrast=\"auto\">0.65,\u00a0<\/span><span data-contrast=\"auto\">95%CI\u00a0<\/span><span data-contrast=\"auto\">0.55<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">0.76).\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">VoPham\u00a0et al. (June 12, 2020). Effect of Social Distancing on COVID-19 Incidence and Mortality in the US. Pre-print\u00a0downloaded June 15 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.06.10.20127589\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.06.10.20127589<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7528\" class=\"su-post\">\n<h5 class=\"su-post-title\">Use of Face Coverings by the Public during the COVID-19 Pandemic\u00a0an\u00a0Observational Study<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Arp et al.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">examined the use of face coverings at grocery stores across 20 counties in Wisconsin<\/span><span data-contrast=\"auto\">\u00a0between May 16 and June 1, 2020<\/span><span data-contrast=\"auto\">. Of 3,271\u00a0<\/span><span data-contrast=\"auto\">people<\/span><span data-contrast=\"auto\">\u00a0observed<\/span><span data-contrast=\"auto\">, 41% used face coverings. Adults<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">(aOR<\/span><span data-contrast=\"auto\">=<\/span><span data-contrast=\"auto\">1.65), females (<\/span><span data-contrast=\"auto\">a<\/span><span data-contrast=\"auto\">OR=<\/span><span data-contrast=\"auto\">1.43) and customers at a more expensive grocery store (<\/span><span data-contrast=\"auto\">a<\/span><span data-contrast=\"auto\">OR=<\/span><span data-contrast=\"auto\">1.95) were more likely to be wearing face coverings.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Arp et al. (June 12, 2020). Use of Face Coverings by the Public during the COVID-19 Pandemic\u00a0an\u00a0Observational Study. Pre-print\u00a0downloaded June 15 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.06.09.20126946\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.06.09.20126946<\/span><\/a><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Transmission<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7536\" class=\"su-post\">\n<h5 class=\"su-post-title\">Maternal Transmission of SARS\u2010COV\u20102 to the Neonate, and Possible Routes for Such Transmission: A Systematic Review and Critical Analysis<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Walker et al.<\/span><span data-contrast=\"auto\">\u00a0conducted a systematic review with 49 studies including 666 neonates to estimate the risk of\u00a0<\/span><span data-contrast=\"auto\">neonat<\/span><span data-contrast=\"auto\">al<\/span><span data-contrast=\"auto\">\u00a0SARS-C<\/span><span data-contrast=\"auto\">o<\/span><span data-contrast=\"auto\">V-2 infection. In total, 8\/292 (<\/span><span data-contrast=\"auto\">3<\/span><span data-contrast=\"auto\">%) vaginally delivered neonates and 20\/374 (5%) Caesarean births\u00a0<\/span><span data-contrast=\"auto\">developed<\/span><span data-contrast=\"auto\">\u00a0confirmed\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2\u00a0<\/span><span data-contrast=\"auto\">infection.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Walker et al. (June 12, 2020). Maternal Transmission of SARS\u2010COV\u20102 to the Neonate, and Possible Routes for Such Transmission: A Systematic Review and Critical Analysis. BJOG: An International Journal of Obstetrics &amp;\u00a0Gynaecology.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1111\/1471-0528.16362\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1111\/1471-0528.16362<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7534\" class=\"su-post\">\n<h5 class=\"su-post-title\">Natural History of Asymptomatic SARS-CoV-2 Infection<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Sakurai et al.<\/span><span data-contrast=\"auto\">\u00a0reported\u00a0<\/span><span data-contrast=\"auto\">a case series<\/span><span data-contrast=\"auto\">\u00a0of 90 patients from the\u202fDiamond Princess\u00a0<\/span><span data-contrast=\"auto\">cruise ship\u00a0<\/span><span data-contrast=\"auto\">who were asymptomatic when\u00a0<\/span><span data-contrast=\"auto\">they\u00a0<\/span><span data-contrast=\"auto\">tested positive for SARS-CoV-2, and\u00a0remained asymptomatic throughout the course of the infection. The median number of days between the first positive PCR result and the first of the two serial negative results was 9 days (IQR 6-11<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0range 3-21), and the cumulative percentages of people with resolution of infection within 8 and 15 days after the first positive result were 48% and 90%, respectively. The<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">likelihood<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">of delayed resolution increased with age.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Sakurai et al. (June 12, 2020). Natural History of Asymptomatic SARS-CoV-2 Infection. New England Journal of Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMc2013020\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1056\/NEJMc2013020<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7532\" class=\"su-post\">\n<h5 class=\"su-post-title\">Duration of Viral Shedding in Asymptomatic or Mild Cases of Novel Coronavirus Disease 2019 (COVID-19) from a Cruise Ship: A Single-Hospital Experience in Tokyo, Japan.<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Miyamae et al<\/span><span data-contrast=\"auto\">. found the median duration of viral shedding among 23\u00a0<\/span><span data-contrast=\"auto\">passengers from\u00a0<\/span><span data-contrast=\"auto\">the Diamond Princess<\/span><span data-contrast=\"auto\">\u00a0cruise ship with\u00a0<\/span><span data-contrast=\"auto\">asymptomatic or mild\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2 infection<\/span><span data-contrast=\"auto\">\u00a0was 19 days (range 6-37 days) from initial viral detection. Eight<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">people<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">(35%) had another positive PCR result after testing negative once.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Miyamae et al. (June 8, 2020). Duration of Viral Shedding in Asymptomatic or Mild Cases of Novel Coronavirus Disease 2019 (COVID-19) from a Cruise Ship: A Single-Hospital Experience in Tokyo, Japan. International Journal of Infectious Diseases.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.ijid.2020.06.020\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.ijid.2020.06.020<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Testing and Treatment<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7544\" class=\"su-post\">\n<h5 class=\"su-post-title\">First Clinical Use of\u00a0Lenzilumab\u00a0to Neutralize GM-CSF in Patients with Severe and Critical COVID-19 Pneumonia<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Temesgen et al.\u00a0<\/span><span data-contrast=\"auto\">reported the use of\u00a0lenzilumab, an anti- GM-CSF monoclonal antibody, in 12 patients with severe COVID-19 pneumonia.\u00a0<\/span><span data-contrast=\"auto\">Of the 12 treated patients,\u00a0<\/span><span data-contrast=\"auto\">11 (92%) patients had significantly improved clinical outcomes. There were no treatment-<\/span><span data-contrast=\"auto\">related\u00a0<\/span><span data-contrast=\"auto\">adverse events and no\u00a0<\/span><span data-contrast=\"auto\">deaths<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Temesgen et al. (June 12, 2020). First Clinical Use of\u00a0Lenzilumab\u00a0to Neutralize GM-CSF in Patients with Severe and Critical COVID-19 Pneumonia. Pre-print\u00a0downloaded June 15 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.06.08.20125369\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.06.08.20125369<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7542\" class=\"su-post\">\n<h5 class=\"su-post-title\">Multiple Assays in a Real-Time RT-PCR SARS-CoV-2 Panel Can Mitigate the Risk of Loss of Sensitivity by New Genomic Variants during the COVID-19 Outbreak<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Penarrubia\u00a0et al.\u00a0<\/span><span data-contrast=\"auto\">assessed the effect of accumulated genetic variability of SARS-CoV-2 on sensitivity of five SARS-CoV-2 PCR assay<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">. A total of 11,627 (34%) genomes includ<\/span><span data-contrast=\"auto\">ed<\/span><span data-contrast=\"auto\">\u00a0single mutations\u00a0<\/span><span data-contrast=\"auto\">that\u00a0<\/span><span data-contrast=\"auto\">affected annealing of a PCR assay. Variations in 8,773 (2<\/span><span data-contrast=\"auto\">6<\/span><span data-contrast=\"auto\">%) genomes were considered high risk, whereas\u00a0<\/span><span data-contrast=\"auto\">an\u00a0<\/span><span data-contrast=\"auto\">additional 2,854 (8.43%) genomes\u00a0<\/span><span data-contrast=\"auto\">had\u00a0<\/span><span data-contrast=\"auto\">single mutations\u00a0<\/span><span data-contrast=\"auto\">that were not\u00a0<\/span><span data-contrast=\"auto\">predicted\u00a0<\/span><span data-contrast=\"auto\">affect<\/span><span data-contrast=\"auto\">\u00a0sensitivity.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">T<\/span><span data-contrast=\"auto\">argeting more than one region in the viral genome for SARS-CoV-2 detection\u00a0<\/span><span data-contrast=\"auto\">may\u00a0<\/span><span data-contrast=\"auto\">mitigate the risk of loss of sensitivity due to the unknown mutation rate during this SARS-CoV-2 outbreak.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Penarrubia\u00a0et al. (June 8, 2020). Multiple Assays in a Real-Time RT-PCR SARS-CoV-2 Panel Can Mitigate the Risk of Loss of Sensitivity by New Genomic Variants during the COVID-19 Outbreak. International Journal of Infectious Diseases.<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1016\/j.ijid.2020.06.027\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.ijid.2020.06.027<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7540\" class=\"su-post\">\n<h5 class=\"su-post-title\">Persistent Viral RNA Shedding after COVID\u201019 Symptom Resolution in Older Convalescent Plasma Donors<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Hartman et al.<\/span><span data-contrast=\"auto\">\u00a0re-tested 86 patients within 28 days after self-reported symptom resolution\u00a0<\/span><span data-contrast=\"auto\">to investigate<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2\u00a0<\/span><span data-contrast=\"auto\">clearance<\/span><span data-contrast=\"auto\">. They found persistent viral shedding\u00a0<\/span><span data-contrast=\"auto\">in<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">11\/86 (13%) participants at a median of 19 days (range 12-24 days) after symptom resolution. Participants with persistent shedding were significantly older (mean<\/span><span data-contrast=\"auto\">\u00a0age<\/span><span data-contrast=\"auto\">\u00a054 years vs. 42<\/span><span data-contrast=\"auto\">\u00a0years<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">and older people were more likely to have<\/span><span data-contrast=\"auto\">\u00a0higher viral concentrations<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">These results\u00a0<\/span><span data-contrast=\"auto\">may have implications for<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">convalescent plasma donors<\/span><span data-contrast=\"auto\">, who may return to clinical facilities<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">within 28 days after symptom resolution<\/span><span data-contrast=\"auto\">\u00a0if viral shedding indicat<\/span><span data-contrast=\"auto\">es<\/span><span data-contrast=\"auto\">\u00a0infectiousness<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Hartman et al. (June 13, 2020). Persistent Viral RNA Shedding after COVID\u201019 Symptom Resolution in Older Convalescent Plasma Donors. Transfusion.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1111\/trf.15927\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1111\/trf.15927<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7538\" class=\"su-post\">\n<h5 class=\"su-post-title\">Nasal-Swab Testing Misses Patients with Low SARS-CoV-2 Viral Loads<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Callahan et al.<\/span><span data-contrast=\"auto\">\u00a0compared results of nasal specimens under 3 transport conditions, traditional viral transport media (VTM), GITC transport medium<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0and dry swabs, to those of standard nasopharynx swabs collected at the same time among 308\u00a0<\/span><span data-contrast=\"auto\">individuals<\/span><span data-contrast=\"auto\">. They observed high concordance (Cohen&#8217;s kappa &gt;0.8) only for patients with viral loads (VL)\u00a0<\/span><span data-contrast=\"auto\">from the nasal samples\u00a0<\/span><span data-contrast=\"auto\">&gt;1000 copies\/mL<\/span><span data-contrast=\"auto\">.\u00a0There was<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">low concordance (Cohen&#8217;s kappa = 0.49)\u00a0<\/span><span data-contrast=\"auto\">for<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">those with VL&lt;1000 copies\/mL<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Callahan et al. (June 14, 2020). Nasal-Swab Testing Misses Patients with Low SARS-CoV-2 Viral Loads. Pre-print\u00a0downloaded June 15 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.06.12.20128736\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.06.12.20128736<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Clinical Characteristics and Health Care Setting<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-7552\" class=\"su-post\">\n<h5 class=\"su-post-title\">Clinical Characteristics of COVID-19 in 104 People with SARS-CoV-2 Infection on the Diamond Princess Cruise Ship:\u00a0A Retrospective\u00a0Analysis<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Tabata et al.\u00a0<\/span><span data-contrast=\"auto\">described the clinical features of 104 people\u00a0<\/span><span data-contrast=\"auto\">with\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2<\/span><span data-contrast=\"auto\">\u00a0infection<\/span><span data-contrast=\"auto\">\u00a0on board the Diamond Princess\u00a0<\/span><span data-contrast=\"auto\">cruise ship\u00a0<\/span><span data-contrast=\"auto\">in<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Tokyo, Japan. On admission<\/span><span data-contrast=\"auto\">\u00a0to hospital<\/span><span data-contrast=\"auto\">, 43 (41%) were asymptomatic, 41 (39%)\u00a0<\/span><span data-contrast=\"auto\">had<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">mild COVID-19, and 20 (19%)\u00a0<\/span><span data-contrast=\"auto\">had<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">severe\u00a0<\/span><span data-contrast=\"auto\">disease<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Patients who progressed to sever disease were older\u00a0<\/span><span data-contrast=\"auto\">age (median<\/span><span data-contrast=\"auto\">\u00a0age<\/span><span data-contrast=\"auto\">\u00a073 years vs. 60; p=0.028),\u00a0<\/span><span data-contrast=\"auto\">were more likely to have\u00a0<\/span><span data-contrast=\"auto\">consolidation on chest CT images (46% vs. 21%; p=0.035), and\u00a0<\/span><span data-contrast=\"auto\">were more likely to have\u00a0<\/span><span data-contrast=\"auto\">lymphopenia (57% vs. 23%; p=0.0055).<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Tabata et al. (June 12, 2020). Clinical Characteristics of COVID-19 in 104 People with SARS-CoV-2 Infection on the Diamond Princess Cruise Ship:\u00a0A Retrospective\u00a0Analysis.\u00a0The Lancet\u00a0Infectious Diseases.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S1473-3099(20)30482-5\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/S1473-3099(20)30482-5<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7550\" class=\"su-post\">\n<h5 class=\"su-post-title\">Clinical Manifestations and Evidence of Neurological Involvement in 2019 Novel Coronavirus SARS-CoV-2: A Systematic Review and Meta-Analysis<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">A meta-analysis\u00a0<\/span><span data-contrast=\"auto\">of<\/span><span data-contrast=\"auto\">\u00a041 articles\u00a0<\/span><span data-contrast=\"auto\">reported a wide spectrum of\u00a0<\/span><span data-contrast=\"auto\">neurological involvement in COVID-19.<\/span><span data-contrast=\"auto\">The\u00a0most common neurological symptoms included olfactory (smell) and gustatory (taste) disorders<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">Guillain-Barre syndrome and inflammation of the brain, spinal cord, and meninges were reported in<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">multiple case series<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Wang et al. (June 4, 2020). Clinical Manifestations and Evidence of Neurological Involvement in 2019 Novel Coronavirus SARS-CoV-2: A Systematic Review and Meta-Analysis. Journal of Neurology.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1007\/s00415-020-09974-2\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1007\/s00415-020-09974-2<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7548\" class=\"su-post\">\n<h5 class=\"su-post-title\">SARS-CoV-2 Shedding and Seroconversion among Passengers Quarantined after Disembarking a Cruise Ship: A Case Series<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Hung et al. reported a case series of 9 adult passengers with COVID-19 who had been on board the Diamond Princess cruise ship in Japan.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">By day 8 of the 14-day quarantine period, eight (89%) were simultaneously positive for nasopharyngeal swab RT-PCR and anti-RBD IgG. Six (67%) remained asymptomatic throughout the quarantine period<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">A combination of RT-PCR and serology\u00a0<\/span><span data-contrast=\"auto\">could improve<\/span><span data-contrast=\"auto\">\u00a0case finding and contact tracing to facilitate early diagnosis, prompt isolation, and treatment.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Hung et al. (June 12, 2020). SARS-CoV-2 Shedding and Seroconversion among Passengers Quarantined after Disembarking a Cruise Ship: A Case Series.\u00a0The Lancet\u00a0Infectious Diseases.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S1473-3099(20)30364-9\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/S1473-3099(20)30364-9<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-7546\" class=\"su-post\">\n<h5 class=\"su-post-title\">Presenting Symptoms of COVID-19 in Children:\u00a0A Meta-Analysis of Published Studies<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Assaker\u00a0et al. performed a meta-analysis\u00a0<\/span><span data-contrast=\"auto\">of<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">28 articles including 1<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">614 individuals to describe COVID-19 symptoms in children. Of 23 studies (<\/span><span data-contrast=\"auto\">n<\/span><span data-contrast=\"auto\">=1<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">543<\/span><span data-contrast=\"auto\">\u00a0patients<\/span><span data-contrast=\"auto\">) describing the\u00a0<\/span><span data-contrast=\"auto\">distribution of COVID-19\u00a0<\/span><span data-contrast=\"auto\">severity,\u00a0<\/span><span data-contrast=\"auto\">they found\u00a0<\/span><span data-contrast=\"auto\">that\u00a0<\/span><span data-contrast=\"auto\">children<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">typically\u00a0<\/span><span data-contrast=\"auto\">present<\/span><span data-contrast=\"auto\">ed<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">with<\/span><span data-contrast=\"auto\">\u00a0mild (37%) or moderate (45%) upper respiratory tract infection<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">and\u00a0<\/span><span data-contrast=\"auto\">cases were\u00a0<\/span><span data-contrast=\"auto\">rarely severe (3%) or critical (0.6%).<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Fever (48% prevalence) and cough (40% prevalence) were the most common symptoms<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Assaker\u00a0et al. (May 31, 2020). Presenting Symptoms of COVID-19 in Children:\u00a0A Meta-Analysis of Published Studies. British Journal of\u00a0Anaesthesia.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.bja.2020.05.026\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/j.bja.2020.05.026<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3><strong>Other Resources and Commentaries<\/strong><\/h3>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1038\/s41577-020-0365-7\"><span data-contrast=\"none\">Passive antibody therapy in COVID-19<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211;\u00a0<\/span><span data-contrast=\"auto\">Nature\u00a0<\/span><span data-contrast=\"auto\">R<\/span><span data-contrast=\"auto\">eviews<\/span><span data-contrast=\"auto\">:<\/span><span data-contrast=\"auto\">\u00a0Immunology (<\/span><span data-contrast=\"auto\">June 12)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/doi.org\/10.4269\/ajtmh.20-0592\"><span data-contrast=\"none\">\u201cSocial Media Misinformation\u201d\u2014An Epidemic within the COVID-19 Pandemic<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211; The American Journal of Tropical Medicine and Hygiene (June 12)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1016\/j.jadohealth.2020.05.021\"><span data-contrast=\"none\">Addressing Health Inequities Exacerbated by COVID-19 Among Youth With HIV: Expanding Our Toolkit<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211; The Journal of Adolescent Health<\/span><span data-contrast=\"auto\">\u00a0(June 8)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1038\/s41591-020-0935-z\"><span data-contrast=\"none\">Ten recommendations for supporting open pathogen genomic analysis in public health<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211; Nature Medicine<\/span><span data-contrast=\"auto\">\u00a0(June 11)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/doi.org\/10.1126\/science.abc4262\"><span data-contrast=\"none\">Can existing live vaccines prevent COVID-19?<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013 Science (<\/span><span data-contrast=\"auto\">June 12)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/doi.org\/10.1001\/jama.2020.11132\"><span data-contrast=\"none\">COVID-19 Pandemic, Unemployment, and Civil Unrest<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211; JAMA (June 12)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/doi.org\/10.1055\/s-0040-1713416\"><span data-contrast=\"none\">The Impact of COVID-19 Infection on Labor and Delivery, Newborn Nursery, and Neonatal Intensive Care Unit: Prospective Observational Data from a Single Hospital System<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211; American Journal of Perinatology (<\/span><span data-contrast=\"auto\">June 13)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/doi.org\/10.1001\/jama.2020.10699\"><span data-contrast=\"none\">Convalescent Plasma and COVID-19<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211; JAMA (June 12)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1126\/science.abb9045\"><span data-contrast=\"none\">Ethics and governance for digital disease surveillance<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211; Science<\/span><span data-contrast=\"auto\">\u00a0(<\/span><span data-contrast=\"auto\">May 29)\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/doi.org\/10.1136\/bmjgh-2020-002909\"><span data-contrast=\"none\">Bridging a false dichotomy in the COVID-19 response: a public health approach to the \u2018lockdown\u2019 debate<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211; BMJ Global Health (June<\/span><span data-contrast=\"auto\">\u00a010)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/doi.org\/10.1056\/NEJMc2018688\"><span data-contrast=\"none\">New-Onset Diabetes in Covid-19<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211; NEJM (<\/span><span data-contrast=\"auto\">June 12)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/doi.org\/10.1056\/NEJMc2019373\"><span data-contrast=\"none\">Neuropathological Features of Covid-19<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211; NEJM (June 12)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"https:\/\/doi.org\/10.1177\/1090198120935073\"><span data-contrast=\"none\">How Fear Appeal Approaches in COVID-19 Health Communication May Be Harming the Global Community<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211; Health Education &amp; Behavior (<\/span><span data-contrast=\"auto\">June 11)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"32\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><a href=\"http:\/\/doi.org\/10.1016\/S0140-6736(20)31354-4\"><span data-contrast=\"none\">COVID-19 vaccines for all?<\/span><\/a><span data-contrast=\"auto\">\u00a0&#8211;\u00a0<\/span><span data-contrast=\"auto\">The Lancet (June 13)<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>A comparison between nasal specimens and standard nasopharynx swabs found high concordance (Cohen&#8217;s kappa &gt;0.8) for the detection of SARS-CoV-2 among patients with viral loads &gt;1000 copies\/mL. Those with viral loads &lt;1000 copies\/mL had low concordance between sample types (Cohen\u2019s kappa = 0.49).<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/15\/presenting-symptoms-of-covid-19-in-children-a-meta-analysis-of-published-studies\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":334,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[5],"tags":[],"topic":[],"class_list":["post-7526","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19-literature-situation-report"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7526"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7526\/revisions"}],"predecessor-version":[{"id":7554,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7526\/revisions\/7554"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media\/334"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7526"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}