{"id":7567,"date":"2020-06-16T15:13:09","date_gmt":"2020-06-16T22:13:09","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7567"},"modified":"2021-03-25T15:13:50","modified_gmt":"2021-03-25T22:13:50","slug":"severe-acute-respiratory-syndrome-coronavirus-2-specific-antibody-responses-in-coronavirus-disease-2019-patients","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/16\/severe-acute-respiratory-syndrome-coronavirus-2-specific-antibody-responses-in-coronavirus-disease-2019-patients\/","title":{"rendered":"Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease 2019 Patients"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Okba\u00a0et al. validated two ELISA serologic assay<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">\u00a0for detection of SARS-CoV-2 antibodies. Among 3 PCR-confirmed SARS-CoV-2-cases<\/span><span data-contrast=\"auto\">\u00a0with serial sample collection<\/span><span data-contrast=\"auto\">, they found that most seroconverted within 2 weeks of disease onset. They found that commercial\u00a0<\/span><span data-contrast=\"auto\">spike protein subunit\u00a0<\/span><span data-contrast=\"auto\">1<\/span><span data-contrast=\"auto\">\u00a0IgG or IgA ELISAs had low specificity and sensitivity varied between the 2 assays (the IgA ELISA showed higher sensitivity).\u00a0<\/span><span data-contrast=\"auto\">T<\/span><span data-contrast=\"auto\">hese results need to be further validated with a larger cohort.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Okba\u00a0et al. (Apr 8, 2020). Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease 2019 Patients. Emerging Infectious Diseases.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.3201\/eid2607.200841\"><span data-contrast=\"none\">https:\/\/doi.org\/10.3201\/eid2607.200841<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Okba\u00a0et al. validated two ELISA serologic assays\u00a0for detection of SARS-CoV-2 antibodies. Among 3 PCR-confirmed SARS-CoV-2-cases\u00a0with serial sample collection, they found that most seroconverted within 2 weeks of disease onset. They found that commercial\u00a0spike protein subunit\u00a01\u00a0IgG or IgA ELISAs had low specificity and sensitivity varied between the 2 assays (the IgA ELISA showed higher sensitivity).\u00a0These results&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/16\/severe-acute-respiratory-syndrome-coronavirus-2-specific-antibody-responses-in-coronavirus-disease-2019-patients\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7567","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7567"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7567\/revisions"}],"predecessor-version":[{"id":7568,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7567\/revisions\/7568"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7567"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}