{"id":7635,"date":"2020-06-18T15:48:53","date_gmt":"2020-06-18T22:48:53","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7635"},"modified":"2021-03-25T15:49:34","modified_gmt":"2021-03-25T22:49:34","slug":"genomewide-association-study-of-severe-covid-19-with-respiratory-failure","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/18\/genomewide-association-study-of-severe-covid-19-with-respiratory-failure\/","title":{"rendered":"Genomewide\u00a0Association Study of Severe Covid-19 with Respiratory Failure"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">A genome<\/span><span data-contrast=\"auto\">&#8211;<\/span><span data-contrast=\"auto\">wide association study involving COVID-19 patients<\/span><span data-contrast=\"auto\">\u00a0(n=1,980)<\/span><span data-contrast=\"auto\">\u00a0at\u00a0<\/span><span data-contrast=\"auto\">7<\/span><span data-contrast=\"auto\">\u00a0hospitals in Europe identified\u00a0<\/span><span data-contrast=\"auto\">two separate loci associated with<\/span><span data-contrast=\"auto\">\u00a0genetic susceptibility\u00a0<\/span><span data-contrast=\"auto\">to severe COVID-19 disease<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">One locus on chromosome 3 spans\u00a0<\/span><span data-contrast=\"auto\">genes<\/span><span data-contrast=\"auto\">\u00a06 genes<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6 and XCR1<\/span><span data-contrast=\"auto\">),\u00a0<\/span><span data-contrast=\"auto\">several of which have functions that are potentially relevant to Covid-19<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">A second locus on chromosome 9 coincides with the ABO blood group locus. These genetic results show blood group O is associated with a lower risk of acquiring COVID-19, whereas blood group A is associated with a higher risk of severe COVID-19. These findings are consistent with previous non-genetic studies that have found an association between blood group A and severe COVID-19<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Ellinghaus<\/span><\/i><i><span data-contrast=\"none\">\u00a0et al. (June 17, 2020).\u00a0<\/span><\/i><i><span data-contrast=\"none\">Genomewide<\/span><\/i><i><span data-contrast=\"none\">\u00a0Association Study of Severe Covid-19 with Respiratory Failure. New England Journal of Medicine.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2020283\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1056\/NEJMoa2020283<\/span><\/a><i><span data-contrast=\"none\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A genome&#8211;wide association study involving COVID-19 patients\u00a0(n=1,980)\u00a0at\u00a07\u00a0hospitals in Europe identified\u00a0two separate loci associated with\u00a0genetic susceptibility\u00a0to severe COVID-19 disease.\u00a0\u00a0 One locus on chromosome 3 spans\u00a0genes\u00a06 genes\u00a0(SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6 and XCR1),\u00a0several of which have functions that are potentially relevant to Covid-19.\u00a0\u00a0 A second locus on chromosome 9 coincides with the ABO blood group locus. These&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/18\/genomewide-association-study-of-severe-covid-19-with-respiratory-failure\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-7635","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7635","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7635"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7635\/revisions"}],"predecessor-version":[{"id":7636,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7635\/revisions\/7636"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7635"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7635"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7635"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7635"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}