{"id":7662,"date":"2021-03-25T11:19:06","date_gmt":"2021-03-25T18:19:06","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7662"},"modified":"2021-03-26T11:19:57","modified_gmt":"2021-03-26T18:19:57","slug":"antibody-responses-after-a-single-dose-of-sars-cov-2-mrna-vaccine","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/25\/antibody-responses-after-a-single-dose-of-sars-cov-2-mrna-vaccine\/","title":{"rendered":"Antibody Responses after a Single Dose of SARS-CoV-2 mRNA Vaccine"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Among healthcare workers who received a single dose of the Pfizer-BioNTech vaccine, those who had SARS-CoV-2 infection 30-60 days prior to vaccination (n=36) had significantly higher antibody levels and higher levels of antibodies with neutralizing characteristics at 3 weeks post-vaccination than individuals with no prior infection (n=152). After the first vaccine dose, both previously infected and uninfected individuals\u2019 antibody titers were enhanced to all proteins (S1, S2, RBD) with the exception of the nucleocapsid protein, which is not a vaccine antigen. <\/span><i><span style=\"font-weight: 400\">[EDITORIAL NOTE: A pre-print version of this manuscript was summarized in this report on February 8, 2021.]<\/span><\/i><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Bradley et al.\u00a0(Mar 23, 2021). Antibody Responses after a Single Dose of SARS-CoV-2 mRNA Vaccine. New England Journal of Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMc2102051\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1056\/NEJMc2102051<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Among healthcare workers who received a single dose of the Pfizer-BioNTech vaccine, those who had SARS-CoV-2 infection 30-60 days prior to vaccination (n=36) had significantly higher antibody levels and higher levels of antibodies with neutralizing characteristics at 3 weeks post-vaccination than individuals with no prior infection (n=152). After the first vaccine dose, both previously infected&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/25\/antibody-responses-after-a-single-dose-of-sars-cov-2-mrna-vaccine\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[33],"topic":[31],"class_list":["post-7662","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7662","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7662"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7662\/revisions"}],"predecessor-version":[{"id":7663,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7662\/revisions\/7663"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7662"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7662"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7662"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7662"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}