{"id":7684,"date":"2020-06-19T11:39:14","date_gmt":"2020-06-19T18:39:14","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=7684"},"modified":"2021-03-26T11:39:54","modified_gmt":"2021-03-26T18:39:54","slug":"combined-point-of-care-nucleic-acid-and-antibody-testing-for-sars-cov-2-a-prospective-cohort-study-in-suspected-moderate-to-severe-covid-19-disease","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/19\/combined-point-of-care-nucleic-acid-and-antibody-testing-for-sars-cov-2-a-prospective-cohort-study-in-suspected-moderate-to-severe-covid-19-disease\/","title":{"rendered":"Combined Point of Care Nucleic Acid and Antibody Testing for SARS-CoV-2 a Prospective Cohort Study in Suspected Moderate to Severe COVID-19 Disease"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-aria-posinset=\"1\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[pre-print, not peer reviewed]<\/span><\/i><span data-contrast=\"auto\">\u00a0Micochova\u00a0et al. compared a combined rapid test (nucleic acid amplification on nose\/throat swab and lateral flow assay antibody test on serum) suitable for point-of-care use with a composite gold standard on 45 patients with suspected moderate to severe COVID-19 disease. In days 1-7 of illness, sensitivity of the nucleic acid test alone was 79.2%, which increased to 100% when combined with the rapid antibody test. Specificity of the combined test in\u00a0<\/span><span data-contrast=\"auto\">days 1-7 of illness was 90% (95% CI 55.5-99.7%). These results show a potentially promising point-of-care approach that improves sensitivity while maintaining relatively high specificity.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Micochova\u00a0et al. (June 18, 2020). Combined Point of Care Nucleic Acid and Antibody Testing for SARS-CoV-2 a Prospective Cohort Study in Suspected Moderate to Severe COVID-19 Disease.\u00a0<\/span><\/i><i><span data-contrast=\"none\">Pre-print downloaded June 19 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.06.16.20133157\"><i><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.06.16.20133157<\/span><\/i><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[pre-print, not peer reviewed]\u00a0Micochova\u00a0et al. compared a combined rapid test (nucleic acid amplification on nose\/throat swab and lateral flow assay antibody test on serum) suitable for point-of-care use with a composite gold standard on 45 patients with suspected moderate to severe COVID-19 disease. In days 1-7 of illness, sensitivity of the nucleic acid test alone&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/06\/19\/combined-point-of-care-nucleic-acid-and-antibody-testing-for-sars-cov-2-a-prospective-cohort-study-in-suspected-moderate-to-severe-covid-19-disease\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-7684","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=7684"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7684\/revisions"}],"predecessor-version":[{"id":7685,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/7684\/revisions\/7685"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=7684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=7684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=7684"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=7684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}